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Rabggtb Rab geranylgeranyltransferase subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 25533, updated on 26-Apr-2024

Summary

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Official Symbol
Rabggtbprovided by RGD
Official Full Name
Rab geranylgeranyltransferase subunit betaprovided by RGD
Primary source
RGD:3530
See related
Ensembl:ENSRNOG00000009992 AllianceGenome:RGD:3530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables several functions, including Rab geranylgeranyltransferase activity; small GTPase binding activity; and zinc ion binding activity. Involved in protein geranylgeranylation. Part of Rab-protein geranylgeranyltransferase complex. Orthologous to human RABGGTB (Rab geranylgeranyltransferase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 515.3), Muscle (RPKM 394.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q45
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (245504586..245510878, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (242844758..242850951, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (260110309..260115574, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and SOCS box-containing 17 Neighboring gene mutS homolog 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA, C/D box 45B Neighboring gene small nucleolar RNA, C/D box 45A Neighboring gene small nucleolar RNA, C/D box 45C Neighboring gene acyl-CoA dehydrogenase medium chain Neighboring gene small nucleolar RNA SNORA15 Neighboring gene uncharacterized LOC134485696

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rab-geranylgeranyl transferase regulates glucose-stimulated insulin secretion from pancreatic β cells. Arora DK, et al. Islets, 2012 Sep-Oct. PMID 23114750, Free PMC Article
  2. Crystal structure of Rab geranylgeranyltransferase at 2.0 A resolution. Zhang H, et al. Structure, 2000 Mar 15. PMID 10745007
  3. Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation. Guo Z, et al. EMBO J, 2008 Sep 17. PMID 18756270, Free PMC Article
  4. cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase. Armstrong SA, et al. J Biol Chem, 1993 Jun 5. PMID 8505342
  5. Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. Pylypenko O, et al. Mol Cell, 2003 Feb. PMID 12620235

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Rab geranylgeranyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables Rab geranylgeranyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables isoprenoid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables small GTPase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein geranylgeranylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Rab-protein geranylgeranyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Rab-protein geranylgeranyltransferase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Rab-protein geranylgeranyltransferase complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
geranylgeranyl transferase type-2 subunit beta
Names
GGTase-II-beta
Rab geranylgeranyl transferase componenet, subunit beta
Rab geranylgeranyltransferase, beta subunit
geranylgeranyl transferase type II subunit beta
rab GG transferase beta
rab GGTase beta
rab geranyl-geranyltransferase subunit beta
type II protein geranyl-geranyltransferase subunit beta
NP_619715.2
XP_063137436.1
XP_063137437.1
XP_063137438.1
XP_063137439.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138708.3 → NP_619715.2  geranylgeranyl transferase type-2 subunit beta

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/Swiss-Prot
    Q08603
    UniProtKB/TrEMBL
    A0A8I6GFF2, A6HWN7, Q68G48
    Related
    ENSRNOP00000086870.1, ENSRNOT00000099311.1
    Conserved Domains (1) summary
    cd02894
    Location:18 → 301
    GGTase-II; Geranylgeranyltransferase type II (GGTase-II)_like proteins containing the protein prenyltransferase (PTase) domain, beta subunit (alpha 6 - alpha 6 barrel fold). GGTase-IIs are a subgroup of the protein prenyltransferase family of lipid-modifying ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    245504586..245510878 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281366.1 → XP_063137436.1  geranylgeranyl transferase type-2 subunit beta isoform X1

  2. XM_063281367.1 → XP_063137437.1  geranylgeranyl transferase type-2 subunit beta isoform X2

  3. XM_063281368.1 → XP_063137438.1  geranylgeranyl transferase type-2 subunit beta isoform X3

    UniProtKB/TrEMBL
    A6HWN9

  4. XM_063281369.1 → XP_063137439.1  geranylgeranyl transferase type-2 subunit beta isoform X4

    UniProtKB/TrEMBL
    A6HWP3

RNA

  1. XR_010063585.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q08603.1 GenPept UniProtKB/Swiss-Prot:Q08603

Gene LinkOut

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