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Sag S-antigen visual arrestin [ Rattus norvegicus (Norway rat) ]

Gene ID: 25539, updated on 13-Apr-2024

Summary

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Official Symbol
Sagprovided by RGD
Official Full Name
S-antigen visual arrestinprovided by RGD
Primary source
RGD:3619
See related
Ensembl:ENSRNOG00000018185 AllianceGenome:RGD:3619
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SAGMR; SANTI
Summary
Enables spectrin binding activity. Predicted to be involved in G protein-coupled receptor internalization. Located in photoreceptor inner segment and photoreceptor outer segment. Human ortholog(s) of this gene implicated in Oguchi disease-1; hereditary night blindness; and retinitis pigmentosa 47. Orthologous to human SAG (S-antigen visual arrestin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 5.9), Lung (RPKM 1.2) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
9q35
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (95915640..95956641)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88467797..88508821)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (94926901..94972162)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene autophagy related 16-like 1 Neighboring gene small Cajal body-specific RNA 6 like Neighboring gene small Cajal body-specific RNA 6 Neighboring gene diacylglycerol kinase, delta Neighboring gene ubiquitin specific peptidase 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Rat pineal S-antigen: sequence analysis reveals presence of alpha-transducin homologous sequence. Abe T, et al. FEBS Lett, 1989 Apr 24. PMID 2714438
  2. S-antigen from the rat retina and pineal gland have identical sequences. Abe T, et al. Exp Eye Res, 1990 Jul. PMID 2373176
  3. Differential expression of mRNA and protein encoding retinal and pineal S-antigen during the light/dark cycle. Craft CM, et al. J Neurochem, 1990 Nov. PMID 2213004
  4. The functional cycle of visual arrestins in photoreceptor cells. Gurevich VV, et al. Prog Retin Eye Res, 2011 Nov. PMID 21824527, Free PMC Article
  5. A homozygous 1-base pair deletion in the arrestin gene is a frequent cause of Oguchi disease in Japanese. Fuchs S, et al. Nat Genet, 1995 Jul. PMID 7670478

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prolonged illumination up-regulates retinal arrestin and Guca1a/b: a novel mechanism for light adaptation.
    Title: Prolonged illumination up-regulates arrestin and two guanylate cyclase activating proteins: a novel mechanism for light adaptation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables opsin binding IEA
Inferred from Electronic Annotation
more info
  
enables opsin binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables spectrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in photoreceptor inner segment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in photoreceptor inner segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in photoreceptor inner segment IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor inner segment ISO
Inferred from Sequence Orthology
more info
  
is_active_in photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in photoreceptor outer segment IEA
Inferred from Electronic Annotation
more info
  
located_in photoreceptor outer segment ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
S-arrestin
Names
48 kDa protein
S-AG
S-antigen; retina and pineal gland (arrestin)
retina and pineal gland (arrestin)
retinal S-antigen
rod photoreceptor arrestin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013023.3 → NP_037155.2  S-arrestin

    See identical proteins and their annotated locations for NP_037155.2

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P15887
    UniProtKB/TrEMBL
    R4GNK4
    Related
    ENSRNOP00000071579.1, ENSRNOT00000085770.2
    Conserved Domains (2) summary
    smart01017
    Location:200 → 361
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:23 → 181
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    95915640..95956641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083069.2 → XP_038938997.1  S-arrestin isoform X1

    UniProtKB/Swiss-Prot
    P15887
    UniProtKB/TrEMBL
    R4GNK4
    Conserved Domains (2) summary
    smart01017
    Location:200 → 361
    Arrestin_C; Arrestin (or S-antigen), C-terminal domain
    cl22903
    Location:23 → 181
    Arrestin_N; Arrestin (or S-antigen), N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P15887.1 GenPept UniProtKB/Swiss-Prot:P15887

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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