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Ccl3 C-C motif chemokine ligand 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25542, updated on 30-Sep-2021

Summary

Official Symbol
Ccl3provided by RGD
Official Full Name
C-C motif chemokine ligand 3provided by RGD
Primary source
RGD:3647
See related
EnsemblRapid:ENSRNOG00000011205
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Scya3; MIP-1a
Summary
mediates monocyte and neutrophil chemotaxis; may play a role in the pathogenesis of acute lung injury [RGD, Feb 2006]
Expression
Biased expression in Thymus (RPKM 59.7), Lung (RPKM 43.4) and 7 other tissues See more
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Genomic context

See Ccl3 in Genome Data Viewer
Location:
10q26
Exon count:
3
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (68451388..68452938, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (70869516..70871066, complement)

Chromosome 10 - NC_051345.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103693406 Neighboring gene C-C motif chemokine ligand 6 Neighboring gene uncharacterized LOC120095160 Neighboring gene C-C motif chemokine ligand 4 Neighboring gene uncharacterized LOC120095331

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables CCR chemokine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CCR1 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables CCR5 chemokine receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
enables calcium-dependent protein kinase C activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chemoattractant activity ISO
Inferred from Sequence Orthology
more info
 
enables chemoattractant activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chemokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chemokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chemokine activity ISO
Inferred from Sequence Orthology
more info
 
enables chemokine activity TAS
Traceable Author Statement
more info
PubMed 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phospholipase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in T cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in astrocyte cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell activation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cell-cell signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular calcium ion homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular calcium ion homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to interferon-gamma IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to interferon-gamma ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interleukin-1 IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to organic cyclic compound ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to tumor necrosis factor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in chemokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in eosinophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in eosinophil chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in eosinophil degranulation ISO
Inferred from Sequence Orthology
more info
 
involved_in eosinophil degranulation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in exocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in granulocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in granulocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in inflammatory response IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in leukocyte chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in lipopolysaccharide-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in lipopolysaccharide-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in lymphocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in lymphocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in lymphocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in macrophage chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in monocyte chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in monocyte chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in monocyte chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation by host of viral transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation by host of viral transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of bone mineralization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of osteoclast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neutrophil chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neutrophil chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in osteoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of calcium-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of calcium-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of natural killer cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of natural killer cell chemotaxis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in protein kinase B signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of behavior ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of behavior ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell shape ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell shape ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of sensory perception of pain ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
 
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to cholesterol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to cholesterol ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
C-C motif chemokine 3
Names
MIP-1-alpha
Macrophage inflammatory protein 1 alpha (Small inducible cytokine A3)
chemokine (C-C motif) ligand 3
macrophage inflammatory protein 1-alpha
small-inducible cytokine A3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013025.2NP_037157.2  C-C motif chemokine 3 precursor

    See identical proteins and their annotated locations for NP_037157.2

    Status: PROVISIONAL

    Source sequence(s)
    U22414
    UniProtKB/Swiss-Prot
    P50229
    Related
    ENSRNOP00000015139.1, ENSRNOT00000015139.4
    Conserved Domains (1) summary
    smart00199
    Location:3185
    SCY; Intercrine alpha family (small cytokine C-X-C) (chemokine CXC)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051345.1 Reference mRatBN7.2 Primary Assembly

    Range
    68451388..68452938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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