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Map2 microtubule-associated protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25595, updated on 3-Apr-2024

Summary

Official Symbol
Map2provided by RGD
Official Full Name
microtubule-associated protein 2provided by RGD
Primary source
RGD:3044
See related
Ensembl:ENSRNOG00000011841 AllianceGenome:RGD:3044
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MAP2R; Mtap2
Summary
Enables actin binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of vesicle transport along microtubule; and response to progesterone. Located in several cellular components, including axon; dendrite; and endoplasmic reticulum. Part of protein-containing complex. Used to study Alzheimer's disease and cerebral infarction. Biomarker of arteriovenous malformation; asphyxia neonatorum; brain ischemia; sciatic neuropathy; and temporal lobe epilepsy. Orthologous to human MAP2 (microtubule associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 797.4) and Adrenal (RPKM 83.9) See more
Orthologs
NEW
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Genomic context

Location:
9q32
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (75173038..75431606)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (67723422..67981886)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (73204753..73462965)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene crystallin, gamma F Neighboring gene splicing regulatory glutamic acid and lysine rich protein 1, pseudogene 1 Neighboring gene unc-80 homolog, NALCN channel complex subunit Neighboring gene KAT8 regulatory NSL complex subunit 1-like Neighboring gene ribulose-5-phosphate-3-epimerase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
 
enables dystroglycan binding IEA
Inferred from Electronic Annotation
more info
 
enables dystroglycan binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in central nervous system neuron development IEA
Inferred from Electronic Annotation
more info
 
involved_in central nervous system neuron development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within dendrite development ISO
Inferred from Sequence Orthology
more info
 
involved_in dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within establishment of cell polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
 
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in microtubule cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of microtubule depolymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of microtubule polymerization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of anterograde dense core granule transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of anterograde synaptic vesicle transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of organelle transport along microtubule IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein localization ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to progesterone IEP
Inferred from Expression Pattern
more info
PubMed 
Component Evidence Code Pubs
located_in CA3 pyramidal cell dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in actin cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in apical dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in apical distal dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon hillock IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon hillock ISO
Inferred from Sequence Orthology
more info
 
located_in axon initial segment IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon initial segment ISO
Inferred from Sequence Orthology
more info
 
located_in basal dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cell body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic branch IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendritic shaft ISO
Inferred from Sequence Orthology
more info
 
located_in distal dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
NOT located_in main axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in microtubule cytoskeleton IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear periphery ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
 
located_in primary dendrite IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in proximal dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in proximal neuron projection IDA
Inferred from Direct Assay
more info
PubMed 
located_in proximal neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in ruffle membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
microtubule-associated protein 2
Names
MAP-2
microtubule-associated protein 2C

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013066.1NP_037198.1  microtubule-associated protein 2

    See identical proteins and their annotated locations for NP_037198.1

    Status: PROVISIONAL

    Source sequence(s)
    X54100
    UniProtKB/Swiss-Prot
    P15146
    UniProtKB/TrEMBL
    Q64715
    Related
    ENSRNOP00000089734.1, ENSRNOT00000110600.1
    Conserved Domains (2) summary
    pfam00418
    Location:16901719
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:3741507
    MAP2_projctn; MAP2/Tau projection domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    75173038..75431606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063266724.1XP_063122794.1  microtubule-associated protein 2 isoform X11

  2. XM_063266731.1XP_063122801.1  microtubule-associated protein 2 isoform X16

    UniProtKB/TrEMBL
    A6KFC4
  3. XM_063266715.1XP_063122785.1  microtubule-associated protein 2 isoform X8

    UniProtKB/TrEMBL
    F1MAQ5
  4. XM_063266720.1XP_063122790.1  microtubule-associated protein 2 isoform X9

  5. XM_063266734.1XP_063122804.1  microtubule-associated protein 2 isoform X20

    UniProtKB/TrEMBL
    A0A9K3Y814, E9PTL3, Q78DZ1
  6. XM_063266718.1XP_063122788.1  microtubule-associated protein 2 isoform X10

  7. XM_017596293.3XP_017451782.1  microtubule-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P15146
    UniProtKB/TrEMBL
    F1LNK0
    Conserved Domains (3) summary
    PTZ00449
    Location:14981772
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:4601593
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:17761806
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  8. XM_063266713.1XP_063122783.1  microtubule-associated protein 2 isoform X6

  9. XM_063266707.1XP_063122777.1  microtubule-associated protein 2 isoform X3

  10. XM_063266717.1XP_063122787.1  microtubule-associated protein 2 isoform X9

  11. XM_063266708.1XP_063122778.1  microtubule-associated protein 2 isoform X4

  12. XM_063266711.1XP_063122781.1  microtubule-associated protein 2 isoform X5

  13. XM_063266726.1XP_063122796.1  microtubule-associated protein 2 isoform X12

  14. XM_039083075.2XP_038939003.1  microtubule-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P15146
    UniProtKB/TrEMBL
    F1LNK0
    Conserved Domains (3) summary
    PTZ00449
    Location:14981772
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:4601593
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:17761806
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  15. XM_063266709.1XP_063122779.1  microtubule-associated protein 2 isoform X3

  16. XM_063266723.1XP_063122793.1  microtubule-associated protein 2 isoform X11

  17. XM_063266722.1XP_063122792.1  microtubule-associated protein 2 isoform X10

  18. XM_063266727.1XP_063122797.1  microtubule-associated protein 2 isoform X12

  19. XM_063266714.1XP_063122784.1  microtubule-associated protein 2 isoform X8

    UniProtKB/TrEMBL
    F1MAQ5
  20. XM_063266729.1XP_063122799.1  microtubule-associated protein 2 isoform X13

  21. XM_063266732.1XP_063122802.1  microtubule-associated protein 2 isoform X16

    UniProtKB/TrEMBL
    A6KFC4
  22. XM_063266735.1XP_063122805.1  microtubule-associated protein 2 isoform X20

    UniProtKB/TrEMBL
    A0A9K3Y814, E9PTL3, Q78DZ1
  23. XM_017596291.3XP_017451780.1  microtubule-associated protein 2 isoform X1

    UniProtKB/Swiss-Prot
    P15146
    UniProtKB/TrEMBL
    F1LNK0
    Conserved Domains (3) summary
    PTZ00449
    Location:14981772
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:4601593
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:17761806
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  24. XM_017596297.3XP_017451786.1  microtubule-associated protein 2 isoform X6

    UniProtKB/TrEMBL
    A0A8I6GHK9
    Conserved Domains (2) summary
    pfam00418
    Location:17761805
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:4601593
    MAP2_projctn; MAP2/Tau projection domain
  25. XM_008767200.4XP_008765422.1  microtubule-associated protein 2 isoform X2

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (2) summary
    pfam00418
    Location:17751804
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:4601592
    MAP2_projctn; MAP2/Tau projection domain
  26. XM_039083078.2XP_038939006.1  microtubule-associated protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A8I6GHK9
    Conserved Domains (3) summary
    PTZ00449
    Location:14981771
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:4601592
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:18061837
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  27. XM_008767199.4XP_008765421.1  microtubule-associated protein 2 isoform X3

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (2) summary
    pfam00418
    Location:17751804
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:4591592
    MAP2_projctn; MAP2/Tau projection domain
  28. XM_017596298.3XP_017451787.1  microtubule-associated protein 2 isoform X8

    UniProtKB/Swiss-Prot
    P15146
    UniProtKB/TrEMBL
    F1MAQ5
    Related
    ENSRNOP00000042029.6
    Conserved Domains (2) summary
    pfam00418
    Location:16941723
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:3781511
    MAP2_projctn; MAP2/Tau projection domain
  29. XM_008767206.4XP_008765428.1  microtubule-associated protein 2 isoform X13

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (2) summary
    pfam00418
    Location:16941723
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:3781511
    MAP2_projctn; MAP2/Tau projection domain
  30. XM_063266719.1XP_063122789.1  microtubule-associated protein 2 isoform X9

  31. XM_039083083.2XP_038939011.1  microtubule-associated protein 2 isoform X14

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (3) summary
    PTZ00449
    Location:14161689
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:3781510
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:17241755
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  32. XM_008767205.4XP_008765427.1  microtubule-associated protein 2 isoform X11

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (2) summary
    pfam00418
    Location:16901719
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
    pfam08377
    Location:3741507
    MAP2_projctn; MAP2/Tau projection domain
  33. XM_039083086.2XP_038939014.1  microtubule-associated protein 2 isoform X17

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (3) summary
    PTZ00449
    Location:14121685
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:3741506
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:17201751
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  34. XM_008767207.4XP_008765429.1  microtubule-associated protein 2 isoform X20

    See identical proteins and their annotated locations for XP_008765429.1

    UniProtKB/TrEMBL
    A0A0U1RS04, A0A9K3Y814, E9PTL3, Q78DZ1
    Related
    ENSRNOP00000031915.5
    Conserved Domains (1) summary
    pfam00418
    Location:332361
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  35. XM_008767208.4XP_008765430.1  microtubule-associated protein 2 isoform X21

    See identical proteins and their annotated locations for XP_008765430.1

    UniProtKB/TrEMBL
    A0A0U1RS04, A6KFC7
    Conserved Domains (1) summary
    pfam00418
    Location:332361
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  36. XM_039083077.2XP_038939005.1  microtubule-associated protein 2 isoform X5

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (3) summary
    PTZ00449
    Location:14961770
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:4581591
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:17741804
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  37. XM_039083081.2XP_038939009.1  microtubule-associated protein 2 isoform X10

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (3) summary
    PTZ00449
    Location:14151689
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:3771510
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:16931723
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  38. XM_039083084.2XP_038939012.1  microtubule-associated protein 2 isoform X15

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (3) summary
    PTZ00449
    Location:14151689
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:3771510
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:17241755
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  39. XM_039083082.2XP_038939010.1  microtubule-associated protein 2 isoform X12

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (3) summary
    PTZ00449
    Location:14111685
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:3731506
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:16891719
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  40. XM_039083085.2XP_038939013.1  microtubule-associated protein 2 isoform X18

    UniProtKB/Swiss-Prot
    P15146
    Conserved Domains (3) summary
    PTZ00449
    Location:14111685
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    pfam08377
    Location:3731506
    MAP2_projctn; MAP2/Tau projection domain
    pfam00418
    Location:17201751
    Tubulin-binding; Tau and MAP protein, tubulin-binding repeat
  41. XM_063266733.1XP_063122803.1  microtubule-associated protein 2 isoform X19

  42. XM_063266737.1XP_063122807.1  microtubule-associated protein 2 isoform X22

  43. XM_063266710.1XP_063122780.1  microtubule-associated protein 2 isoform X3

  44. XM_063266716.1XP_063122786.1  microtubule-associated protein 2 isoform X8

    UniProtKB/TrEMBL
    F1MAQ5
  45. XM_063266730.1XP_063122800.1  microtubule-associated protein 2 isoform X13

  46. XM_063266725.1XP_063122795.1  microtubule-associated protein 2 isoform X11

  47. XM_063266736.1XP_063122806.1  microtubule-associated protein 2 isoform X20

    UniProtKB/TrEMBL
    A0A9K3Y814, E9PTL3, Q78DZ1
  48. XM_063266712.1XP_063122782.1  microtubule-associated protein 2 isoform X5

  49. XM_063266721.1XP_063122791.1  microtubule-associated protein 2 isoform X10

  50. XM_063266728.1XP_063122798.1  microtubule-associated protein 2 isoform X12