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Crem cAMP responsive element modulator [ Rattus norvegicus (Norway rat) ]

Gene ID: 25620, updated on 13-Apr-2024

Summary

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Official Symbol
Cremprovided by RGD
Official Full Name
cAMP responsive element modulatorprovided by RGD
Primary source
RGD:2402
See related
Ensembl:ENSRNOG00000014900 AllianceGenome:RGD:2402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Icer
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including glucose metabolic process; regulation of circadian rhythm; and retinoic acid receptor signaling pathway. Predicted to be located in cytoplasm and nucleus. Predicted to be part of ATF4-CREB1 transcription factor complex. Biomarker of transient cerebral ischemia. Orthologous to human CREM (cAMP responsive element modulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 90.5), Testes (RPKM 74.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Crem in Genome Data Viewer
Location:
17q12.1
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (58932011..59001160)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (54238889..54305989)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (57021704..57090888)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930596D02 gene like 2 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene cullin 2 Neighboring gene uncharacterized LOC108348578 Neighboring gene Histone deacetylase 1, pseudogene 12 Neighboring gene marker of proliferation Ki-67, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effects of Fluoride on Expression of P450, CREM and ACT Proteins in Rat Testes. Zhang J, et al. Biol Trace Elem Res, 2017 Jan. PMID 27234251
  2. Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes. Bitar MS, et al. Dis Model Mech, 2015 Jan. PMID 25381014, Free PMC Article
  3. Silencing of ICERs (Inducible cAMP Early Repressors) results in partial protection of neurons from programmed cell death. Bieganska K, et al. Neurobiol Dis, 2012 Feb. PMID 22044735
  4. Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene. Steinbicker AU, et al. Nitric Oxide, 2011 Oct 30. PMID 21642009, Free PMC Article
  5. Role of cAMP-responsive element modulator-tau (CREMtau) in ipsilateral testicular injury after unilateral testicular torsion-detorsion. Wei SM, et al. Fertil Steril, 2008 Jun. PMID 17681298

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression levels of ICER and BDNF were increased remarkably but the GABAA R alpha1 subunit decreased significantly in the drug-resistant epileptic rats. However, the expression levels of ICER, BDNF were decreased and the expression of the GABAA R alpha1 subunit increased significantly in the drug-resistant epileptic rats after two weeks of Hip-LFS.
    Title: Influence of hippocampal low-frequency stimulation on GABA(A) R α1, ICER and BNDF expression level in brain tissues of amygdala-kindled drug-resistant temporal lobe epileptic rats.
  2. Using an ADHD rat model, we demonstrate that impulsive animals are neurochemically and behaviorally more sensitive to heroin and exhibit reduced Crem expression in the nucleus accumbens core.
    Title: Ventral striatal regulation of CREM mediates impulsive action and drug addiction vulnerability.
  3. These data suggest that fluoride can impair male reproduction by affecting expression of P450, CREM, and ACT in the testes.
    Title: Effects of Fluoride on Expression of P450, CREM and ACT Proteins in Rat Testes.
  4. The ERK1/2 and ICER-mediated feed forward loop is the hidden design principle underlying the switching role of beta-adrenergic receptor signaling in cell survival or death decision of cardiomyocytes.
    Title: The switching role of β-adrenergic receptor signalling in cell survival or death decision of cardiomyocytes.
  5. CREM/ICER is a negative regulator of endothelial function
    Title: Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes.
  6. Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1gamma.
    Title: Hyperglycemia downregulates Connexin36 in pancreatic islets via the upregulation of ICER-1/ICER-1γ.
  7. CREM-1 may play an important role in regulating neuronal death after traumatic brain injury by interacting with cyclic AMP response element-binding protein (CREB).
    Title: Cyclic AMP response element modulator-1 (CREM-1) involves in neuronal apoptosis after traumatic brain injury.
  8. The induction of ICER in GSNO-treated RPaSMC highlights a novel cross-talk mechanism between cGMP and cAMP signaling pathways.
    Title: Nitric oxide regulates pulmonary vascular smooth muscle cell expression of the inducible cAMP early repressor gene.
  9. we have found that silencing of ICERs enhances the CRE-driven transcription and exerts a mild, although significant, neuroprotective effect
    Title: Silencing of ICERs (Inducible cAMP Early Repressors) results in partial protection of neurons from programmed cell death.
  10. Induction of ICER links oxidative stress to beta cell failure caused by oxidised LDL, and it can be effectively abrogated by antioxidant treatment.
    Title: Role for inducible cAMP early repressor in promoting pancreatic beta cell dysfunction evoked by oxidative stress in human and rat islets.
Submit: New GeneRIF Correction See all GeneRIFs (31)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling TAS
Traceable Author Statement
more info
 PubMed 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glucose metabolic process IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in glycosphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycosphingolipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to cAMP ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid receptor signaling pathway IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ATF4-CREB1 transcription factor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cAMP-responsive element modulator
Names
CRE modulator
cAMP responsive element moderator
inducible cyclic AMP early repressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001110860.2 → NP_001104330.1  cAMP-responsive element modulator isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes isoform 3.
    Source sequence(s)
    BC078899, JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A140TAC1, A6K9H0
    Related
    ENSRNOP00000020204.6, ENSRNOT00000020204.7
    Conserved Domains (2) summary
    cd14690
    Location:301 → 355
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  2. NM_001271101.1 → NP_001258030.1  cAMP-responsive element modulator isoform 4

    See identical proteins and their annotated locations for NP_001258030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, compared to variant 3. This results in protein (isoform 4) that is the same length but has a distinct C-terminus, compared to isoform 3.
    Source sequence(s)
    BC078899, JAXUCZ010000017
    UniProtKB/Swiss-Prot
    Q03061, Q6AYV1
    UniProtKB/TrEMBL
    A0A8I6ACV8
    Related
    ENSRNOP00000090155.1, ENSRNOT00000115950.1
    Conserved Domains (2) summary
    cd14690
    Location:301 → 355
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:112 → 151
    pKID; pKID domain

  3. NM_001271102.1 → NP_001258031.1  cAMP-responsive element modulator isoform 5

    See identical proteins and their annotated locations for NP_001258031.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in 5' UTR and 5' coding region, compared to variant 3. This results in a protein (isoform 5) that is shorter and has a distinct N-terminus compared to isoform 3.
    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:57 → 111
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  4. NM_001271245.1 → NP_001258174.1  cAMP-responsive element modulator isoform 6

    See identical proteins and their annotated locations for NP_001258174.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 3. This results in a protein (isoform 6) that is shorter at both the N- and C-termini, compared to isoform 3.
    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6K9H5, Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:63 → 117
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  5. NM_001271246.1 → NP_001258175.1  cAMP-responsive element modulator isoform 7

    See identical proteins and their annotated locations for NP_001258175.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in 5' UTR and 5' coding region, compared to variant 3. This results in a protein (isoform 7) that has a shorter N-terminus compared to isoform 3.
    Source sequence(s)
    FM089481, JAXUCZ010000017
    UniProtKB/TrEMBL
    A0A0G2K748, A6K9H6, Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:46 → 100
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  6. NM_001271247.1 → NP_001258176.1  cAMP-responsive element modulator isoform 8

    See identical proteins and their annotated locations for NP_001258176.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in 5' UTR and 5' coding region, compared to variant 3. This results in a protein (isoform 8) that has a shorter N-terminus compared to isoform 3.
    Source sequence(s)
    FM033648, JAXUCZ010000017
    UniProtKB/TrEMBL
    Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:63 → 117
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  7. NM_001271248.1 → NP_001258177.1  cAMP-responsive element modulator isoform 9

    See identical proteins and their annotated locations for NP_001258177.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 3. This results in a protein (isoform 9) that is shorter at both the N- and C-termini, compared to isoform 3.
    Source sequence(s)
    CO556486, JAXUCZ010000017
    UniProtKB/TrEMBL
    A6K9H7, Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:39 → 93
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  8. NM_017334.2 → NP_059030.2  cAMP-responsive element modulator isoform 2

    See identical proteins and their annotated locations for NP_059030.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in both UTR's and the coding region but maintains the reading frame, compared to variant 3. This results in a protein (isoform 2) that is shorter at both the N- and C-termini, compared to isoform 3.
    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/TrEMBL
    A6K9H3
    Conserved Domains (1) summary
    cd14690
    Location:69 → 123
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    58932011..59001160
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063276102.1 → XP_063132172.1  cAMP-responsive element modulator isoform X29

  2. XM_063276103.1 → XP_063132173.1  cAMP-responsive element modulator isoform X30

  3. XM_063276105.1 → XP_063132175.1  cAMP-responsive element modulator isoform X33

  4. XM_039095385.2 → XP_038951313.1  cAMP-responsive element modulator isoform X36

    UniProtKB/TrEMBL
    Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:39 → 93
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  5. XM_006254051.5 → XP_006254113.1  cAMP-responsive element modulator isoform X4

    UniProtKB/TrEMBL
    A6K9H0
    Conserved Domains (2) summary
    cd14690
    Location:285 → 339
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:96 → 135
    pKID; pKID domain

  6. XM_039095381.2 → XP_038951309.1  cAMP-responsive element modulator isoform X13

    UniProtKB/TrEMBL
    A6K9H0
    Conserved Domains (2) summary
    cd14690
    Location:236 → 290
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:47 → 86
    pKID; pKID domain

  7. XM_063276081.1 → XP_063132151.1  cAMP-responsive element modulator isoform X1

    UniProtKB/TrEMBL
    A0A140TAC1

  8. XM_063276083.1 → XP_063132153.1  cAMP-responsive element modulator isoform X3

  9. XM_063276090.1 → XP_063132160.1  cAMP-responsive element modulator isoform X12

    UniProtKB/TrEMBL
    A0A0G2JYV9

  10. XM_063276092.1 → XP_063132162.1  cAMP-responsive element modulator isoform X15

  11. XM_063276085.1 → XP_063132155.1  cAMP-responsive element modulator isoform X6

    UniProtKB/TrEMBL
    A0A8L2QUF6

  12. XM_063276086.1 → XP_063132156.1  cAMP-responsive element modulator isoform X7

  13. XM_063276089.1 → XP_063132159.1  cAMP-responsive element modulator isoform X11

  14. XM_063276095.1 → XP_063132165.1  cAMP-responsive element modulator isoform X21

  15. XM_063276096.1 → XP_063132166.1  cAMP-responsive element modulator isoform X22

  16. XM_063276099.1 → XP_063132169.1  cAMP-responsive element modulator isoform X25

  17. XM_063276082.1 → XP_063132152.1  cAMP-responsive element modulator isoform X2

  18. XM_063276091.1 → XP_063132161.1  cAMP-responsive element modulator isoform X14

    UniProtKB/TrEMBL
    A0A140TAC0

  19. XM_063276088.1 → XP_063132158.1  cAMP-responsive element modulator isoform X10

  20. XM_063276098.1 → XP_063132168.1  cAMP-responsive element modulator isoform X24

  21. XM_063276093.1 → XP_063132163.1  cAMP-responsive element modulator isoform X18

  22. XM_039095386.2 → XP_038951314.1  cAMP-responsive element modulator isoform X36

    UniProtKB/TrEMBL
    Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:39 → 93
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  23. XM_008771692.3 → XP_008769914.1  cAMP-responsive element modulator isoform X35

    See identical proteins and their annotated locations for XP_008769914.1

    UniProtKB/TrEMBL
    A0A0G2K748, A6K9H6, Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:46 → 100
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  24. XM_063276084.1 → XP_063132154.1  cAMP-responsive element modulator isoform X5

  25. XM_006254061.5 → XP_006254123.1  cAMP-responsive element modulator isoform X17

    UniProtKB/TrEMBL
    A0A8I5ZW07, D3ZXY8
    Related
    ENSRNOP00000083169.1
    Conserved Domains (2) summary
    cd14690
    Location:224 → 278
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:35 → 74
    pKID; pKID domain

  26. XM_006254062.5 → XP_006254124.1  cAMP-responsive element modulator isoform X19

    UniProtKB/TrEMBL
    D3ZXY8
    Related
    ENSRNOP00000020012.7
    Conserved Domains (2) summary
    cd14690
    Location:212 → 266
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:35 → 74
    pKID; pKID domain

  27. XM_006254068.5 → XP_006254130.1  cAMP-responsive element modulator isoform X27

    Conserved Domains (2) summary
    cd14690
    Location:149 → 203
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:35 → 74
    pKID; pKID domain

  28. XM_063276100.1 → XP_063132170.1  cAMP-responsive element modulator isoform X26

  29. XM_006254060.5 → XP_006254122.1  cAMP-responsive element modulator isoform X16

    UniProtKB/TrEMBL
    D3ZXY8
    Conserved Domains (2) summary
    cd14690
    Location:224 → 278
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:35 → 74
    pKID; pKID domain

  30. XM_063276087.1 → XP_063132157.1  cAMP-responsive element modulator isoform X9

  31. XM_063276097.1 → XP_063132167.1  cAMP-responsive element modulator isoform X23

  32. XM_006254054.5 → XP_006254116.1  cAMP-responsive element modulator isoform X8

    See identical proteins and their annotated locations for XP_006254116.1

    UniProtKB/TrEMBL
    A6K9H0
    Conserved Domains (2) summary
    cd14690
    Location:248 → 302
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain
    pfam02173
    Location:59 → 98
    pKID; pKID domain

  33. XM_063276094.1 → XP_063132164.1  cAMP-responsive element modulator isoform X20

  34. XM_063276101.1 → XP_063132171.1  cAMP-responsive element modulator isoform X28

  35. XM_063276104.1 → XP_063132174.1  cAMP-responsive element modulator isoform X31

    UniProtKB/TrEMBL
    A6K9H4

  36. XM_006254069.5 → XP_006254131.1  cAMP-responsive element modulator isoform X31

    See identical proteins and their annotated locations for XP_006254131.1

    UniProtKB/TrEMBL
    A6K9H4, Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:69 → 123
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  37. XM_006254070.5 → XP_006254132.1  cAMP-responsive element modulator isoform X34

    See identical proteins and their annotated locations for XP_006254132.1

    UniProtKB/TrEMBL
    Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:57 → 111
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

  38. XM_008771691.4 → XP_008769913.1  cAMP-responsive element modulator isoform X32

    See identical proteins and their annotated locations for XP_008769913.1

    UniProtKB/TrEMBL
    Q9R1Q5
    Conserved Domains (1) summary
    cd14690
    Location:63 → 117
    bZIP_CREB1; Basic leucine zipper (bZIP) domain of Cyclic AMP-responsive element-binding protein 1 (CREB1) and similar proteins: a DNA-binding and dimerization domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_013086.1: Suppressed sequence

    Description
    NM_013086.1: This RefSeq was permanently suppressed because it contains the wrong CDS, and it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q03061.2 GenPept UniProtKB/Swiss-Prot:Q03061

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