Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Cyp3a23-3a1provided by RGD
Full Name: cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1provided by RGD
Primary source: RGD:628626
See related: Ensembl:ENSRNOG00000067532 AllianceGenome:RGD:628626
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: CYP; RL33; cDEX; Cyp3a1; Cyp3a3; CYP3A23; Cyp3a23/3a1; AABR07035343.1
Summary: Enables demethylase activity and testosterone 6-beta-hydroxylase activity. Involved in several processes, including oxidative demethylation; response to cadmium ion; and response to dexamethasone. Located in endoplasmic reticulum membrane. Biomarker of cholestasis and mental depression. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; chronic myeloid leukemia; and essential hypertension. Orthologous to human CYP3A5 (cytochrome P450 family 3 subfamily A member 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 5888.8) See more
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Genomic context

Location:: 12p11

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (14369950..14398803, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (9256159..9285020, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (11053888..11082742, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats.
Title: CYP3A deficiency alters bile acid homeostasis and leads to changes in hepatic susceptibility in rats.
Due to significant increases in the expressions of CYP3A1 and CES1.
Title: Effect of X-ray irradiation on pharmacokinetics of irinotecan hydrochloride and expression of CES1 and CYP3A1 in rats.
Early- and late-stage cholestasis affect CYP3A-mediated drug metabolism differently.
Title: Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis.
Data suggest that liver oxidative damage induced by industrial fungicide bromuconazole is due, in part, to up-regulation of PXR/CYP3A1 expression and down-regulation of CAR/CYP2B1 expression. (PXR = pregnane X receptor; CYP3A1 = cytochrome P-450 3A1; CAR = constitutive androstane receptor; CYP2B1 = cytochrome P-450 2B1)
Title: Bromuconazole-induced hepatotoxicity is accompanied by upregulation of PXR/CYP3A1 and downregulation of CAR/CYP2B1 gene expression.
The effect of rutin and hesperidin on the expression of Nrf2- and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride.
Title: [The effect of rutin and hesperidin on the expression of Nrf2- and AhR-regulated genes and CYP3A1 gene in rats intoxicated with carbon tetrachloride].
CYP3A1 activity was reduced in rats after acute exposure to high altitude of 4300m and metronidazole.
Title: The effects of metronidazole on Cytochrome P450 Activity and Expression in rats after acute exposure to high altitude of 4300m.
These findings demonstrate that Acetaminophen (APAP) induces accumulation of functional CYP3A protein via inhibition of protein degradation. Our findings may lead to the determination of novel drug-drug interactions with APAP
Title: Acetaminophen induces accumulation of functional rat CYP3A via polyubiquitination dysfunction.
Report a CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat CYP3A1 gene.
Title: A CAR-responsive enhancer element locating approximately 31 kb upstream in the 5'-flanking region of rat cytochrome P450 (CYP) 3A1 gene.
Schizonepetin induced the expression of CYP3A1, CYP1A2 and CYP2E1 at dosages of 24 and 48 mg/kg.
Title: Effects of schizonepetin on activity and mRNA expression of cytochrome p450 enzymes in rats.
These findings suggest that Valeriana officinalis extract can decrease the CYP3A4 expression and therefore may lead to interactions with synthetic drugs metabolized by this enzyme.
Title: The influence of standardized Valeriana officinalis extract on the CYP3A1 gene expression by nuclear receptors in in vivo model.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH132534 (e-PCR)
- UniSTS:215817

RH94398 (e-PCR)
- UniSTS:119646

Cyp3a11 (e-PCR), detects polymorphism
- UniSTS:463002

RH142381 (e-PCR)
- UniSTS:231628

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables demethylase activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables testosterone 6-beta-hydroxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables testosterone 6-beta-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in oxidative demethylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in oxidative demethylation	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to dexamethasone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to metal ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in steroid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in xenobiotic metabolic process	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 3A1

Names: CYPIIIA1; Cytochrome P450, subfamily IIIA, polypeptide 3; P450 IIIA; P450-PCN1; cytochrome P-450; cytochrome P-450PCN (PNCN inducible); cytochrome P450 3A1-like; cytochrome P450, family 3, subfamily a, polypeptide 1; cytochrome P450, subfamily 3A, polypeptide 3; cytochrome P450-PCN1; cytochrome P450/6 beta B

NP_037237.2

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.