Format

Send to:

Choose Destination

Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25642, updated on 22-Aug-2021

Summary

Symbol
Cyp3a23-3a1provided by RGD
Full Name
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1provided by RGD
Primary source
RGD:628626
See related
Ensembl:ENSRNOG00000032560
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
CYP; RL33; cDEX; Cyp3a1; Cyp3a3; CYP3A23; Cyp3a23/3a1
Summary
steroid-inducible member of p450 subfamily 3A; induced by pregnenolone 16 alpha-carbonitrile, dexamethasone (DEX), phenobarbital (PB) and triacetyloleandomycin [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 5888.8) See more
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Cyp3a23-3a1 in Genome Data Viewer
Location:
12p11
Exon count:
13
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (9256159..9285020, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (11053888..11082742, complement)

Chromosome 12 - NC_051347.1Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 71, pseudogene Neighboring gene cytochrome P450, family 3, subfamily a, polypeptide 2 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene similar to developmental pluripotency associated 4 isoform 1 Neighboring gene zinc finger and SCAN domain containing 25

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC108757

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
 
enables demethylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables steroid hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables testosterone 6-beta-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables testosterone 6-beta-hydroxylase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in aging IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in oxidative demethylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in oxidative demethylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to cadmium ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to dexamethasone IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to glucocorticoid IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to metal ion IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to nutrient IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in response to xenobiotic stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in xenobiotic metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome P450 3A1
Names
CYPIIIA1
Cytochrome P450, subfamily IIIA, polypeptide 3
P450 IIIA
P450-PCN1
cytochrome P-450
cytochrome P-450PCN (PNCN inducible)
cytochrome P450 3A1-like
cytochrome P450, family 3, subfamily a, polypeptide 1
cytochrome P450, subfamily 3A, polypeptide 3
cytochrome P450-PCN1
cytochrome P450/6 beta B
NP_037237.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013105.2NP_037237.2  cytochrome P450 3A1

    See identical proteins and their annotated locations for NP_037237.2

    Status: PROVISIONAL

    Source sequence(s)
    BC088163
    UniProtKB/TrEMBL
    Q06884
    Conserved Domains (1) summary
    pfam00067
    Location:39492
    p450; Cytochrome P450

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051347.1 Reference mRatBN7.2 Primary Assembly

    Range
    9256159..9285020 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center