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Cpe carboxypeptidase E [ Rattus norvegicus (Norway rat) ]

Gene ID: 25669, updated on 24-Jul-2021

Summary

Official Symbol
Cpeprovided by RGD
Official Full Name
carboxypeptidase Eprovided by RGD
Primary source
RGD:2394
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cph; CARBE
Summary
may play a role in post-translational processing of peptide hormones including preproopiomelanocortin [RGD, Feb 2006]
Expression
Biased expression in Brain (RPKM 2437.3), Heart (RPKM 767.8) and 3 other tissues See more
Orthologs
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Genomic context

See Cpe in Genome Data Viewer
Location:
16p13
Exon count:
9
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (25030276..25142231)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (26906716..27014811)

Chromosome 16 - NC_051351.1Genomic Context describing neighboring genes Neighboring gene methylsterol monooxygenase 1 Neighboring gene uncharacterized LOC120097471 Neighboring gene glucocorticoid receptor DNA binding factor 1, pseudogene 1 Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC93638

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carboxypeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables carboxypeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 
enables cell adhesion molecule binding ISO
Inferred from Sequence Orthology
more info
 
enables cobalt ion binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables neurexin family protein binding IEA
Inferred from Electronic Annotation
more info
 
enables neurexin family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cardiac left ventricle morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in cardiac left ventricle morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in enkephalin processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin processing IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within insulin processing ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of branching morphogenesis of a nerve IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptide catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptide hormone processing TAS
Traceable Author Statement
more info
PubMed 
involved_in peptide hormone secretion IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within peptide hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in peptide metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein localization to membrane IEA
Inferred from Electronic Annotation
more info
 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to secretory granule IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein localization to secretory granule ISO
Inferred from Sequence Orthology
more info
 
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein processing IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in dense core granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane raft IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
located_in perikaryon IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in secretory granule membrane IEA
Inferred from Electronic Annotation
more info
 
located_in secretory granule membrane ISO
Inferred from Sequence Orthology
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
carboxypeptidase E
Names
carboxypeptidase H
enkephalin convertase
prohormone-processing carboxypeptidase
NP_037260.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013128.2NP_037260.2  carboxypeptidase E precursor

    Status: PROVISIONAL

    Source sequence(s)
    JACYVU010000279
    Conserved Domains (2) summary
    cd11308
    Location:375449
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd03865
    Location:53371
    M14_CPE; Peptidase M14 carboxypeptidase subfamily N/E-like; Carboxypeptidase E subgroup

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051351.1 Reference mRatBN7.2 Primary Assembly

    Range
    25030276..25142231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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