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Cd3d CD3 delta subunit of T-cell receptor complex [ Rattus norvegicus (Norway rat) ]

Gene ID: 25710, updated on 5-Mar-2024

Summary

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Official Symbol
Cd3dprovided by RGD
Official Full Name
CD3 delta subunit of T-cell receptor complexprovided by RGD
Primary source
RGD:2304
See related
Ensembl:ENSRNOG00000015994 AllianceGenome:RGD:2304
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in cell surface receptor signaling pathway and positive thymic T cell selection. Predicted to be integral component of membrane. Predicted to be part of alpha-beta T cell receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in immunodeficiency 19 and severe combined immunodeficiency. Orthologous to human CD3D (CD3d molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 3195.3) See more
Orthologs
human mouse all
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Genomic context

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Location:
8q22
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54184573..54190112)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45287803..45293342)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49282502..49287095)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene ubiquitination factor E4A Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class A, pseudogene 1 Neighboring gene CD3 gamma subunit of T-cell receptor complex Neighboring gene CD3 epsilon subunit of T-cell receptor complex Neighboring gene myelin protein zero-like 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Initiation of TCR signaling: regulation within CD3 dimers. Alarcón B, et al. Immunol Rev, 2003 Feb. PMID 12614350
  2. The role of modified purine 64 in initiator/elongator discrimination of tRNA(iMet) from yeast and wheat germ. Kiesewetter S, et al. Nucleic Acids Res, 1990 Aug 25. PMID 2395634, Free PMC Article
  3. Nucleotide sequence of a cDNA encoding the rat T3 delta chain. Davies JD, et al. Nucleic Acids Res, 1990 Aug 11. PMID 2143819, Free PMC Article
  4. Effect of CD3delta deficiency on maturation of alpha/beta and gamma/delta T-cell lineages in severe combined immunodeficiency. Dadi HK, et al. N Engl J Med, 2003 Nov 6. PMID 14602880
  5. Biochemical evidence for the presence of a single CD3delta and CD3gamma chain in the surface T cell receptor/CD3 complex. Pan Q, et al. J Biol Chem, 2004 Dec 3. PMID 15459203

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in positive thymic T cell selection IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive thymic T cell selection ISO
Inferred from Sequence Orthology
more info
  
involved_in positive thymic T cell selection ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
  
part_of alpha-beta T cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of alpha-beta T cell receptor complex IEA
Inferred from Electronic Annotation
more info
  
part_of alpha-beta T cell receptor complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
T-cell surface glycoprotein CD3 delta chain
Names
CD3 antigen delta polypeptide
CD3 molecule delta polypeptide
CD3 molecule, delta
CD3d molecule
T-cell receptor T3 delta chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013169.1 → NP_037301.1  T-cell surface glycoprotein CD3 delta chain precursor

    See identical proteins and their annotated locations for NP_037301.1

    Status: PROVISIONAL

    Source sequence(s)
    X53430
    UniProtKB/Swiss-Prot
    P19377
    UniProtKB/TrEMBL
    A0A8L2QB67, A6J422
    Related
    ENSRNOP00000021489.4, ENSRNOT00000021488.6
    Conserved Domains (2) summary
    pfam02189
    Location:146 → 165
    ITAM; Immunoreceptor tyrosine-based activation motif
    pfam16680
    Location:31 → 95
    Ig_4; T-cell surface glycoprotein CD3 delta chain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    54184573..54190112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080903.2 → XP_038936831.1  T-cell surface glycoprotein CD3 delta chain isoform X1

    Conserved Domains (2) summary
    pfam02189
    Location:73 → 92
    ITAM; Immunoreceptor tyrosine-based activation motif
    cl11960
    Location:19 → 31
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P19377.1 GenPept UniProtKB/Swiss-Prot:P19377

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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