U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Syt3 synaptotagmin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25731, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Syt3provided by RGD
Official Full Name
synaptotagmin 3provided by RGD
Primary source
RGD:3805
See related
Ensembl:ENSRNOG00000019318 AllianceGenome:RGD:3805
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
SIII
Summary
Enables clathrin binding activity; phospholipid binding activity; and syntaxin binding activity. Involved in positive regulation of vesicle fusion; regulation of calcium ion-dependent exocytosis; and response to calcium ion. Is integral component of synaptic membrane. Orthologous to human SYT3 (synaptotagmin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 85.2), Heart (RPKM 12.8) and 3 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q22
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104017341..104032046)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94880835..94895518)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100379236..100407862)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain containing 11A Neighboring gene SH3 and multiple ankyrin repeat domains 1 Neighboring gene simlar to human chromosome 19 open reading frame 81 Neighboring gene uncharacterized LOC108349570 Neighboring gene leucine rich repeat containing 4B Neighboring gene aspartate dehydrogenase domain containing

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Crystal structure of the cytosolic C2A-C2B domains of synaptotagmin III. Implications for Ca(+2)-independent snare complex interaction. Sutton RB, et al. J Cell Biol, 1999 Nov 1. PMID 10545502, Free PMC Article
  2. Synaptotagmin III is a novel isoform of rat synaptotagmin expressed in endocrine and neuronal cells. Mizuta M, et al. J Biol Chem, 1994 Apr 22. PMID 8163462
  3. The subcellular localizations of atypical synaptotagmins III and VI. Synaptotagmin III is enriched in synapses and synaptic plasma membranes but not in synaptic vesicles. Butz S, et al. J Biol Chem, 1999 Jun 25. PMID 10373432
  4. Lymph node mapping in patients with bladder cancer undergoing radical cystectomy and lymph node dissection to the level of the inferior mesenteric artery. Jensen JB, et al. BJU Int, 2010 Jul. PMID 20002670
  5. Analysis of the synaptotagmin family during reconstituted membrane fusion. Uncovering a class of inhibitory isoforms. Bhalla A, et al. J Biol Chem, 2008 Aug 1. PMID 18508778, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding TAS
Traceable Author Statement
more info
 PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent phospholipid binding ISO
Inferred from Sequence Orthology
more info
  
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables clathrin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables syntaxin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium-ion regulated exocytosis TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of dendrite extension ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of vesicle fusion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of calcium ion-dependent exocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to calcium ion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in synaptic vesicle exocytosis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynapse IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic membrane EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
synaptotagmin-3
Names
synaptotagmin III
sytIII

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_019122.1 → NP_061995.1  synaptotagmin-3

    See identical proteins and their annotated locations for NP_061995.1

    Status: PROVISIONAL

    Source sequence(s)
    D28512
    UniProtKB/Swiss-Prot
    P40748, Q925B7
    UniProtKB/TrEMBL
    B1AC44
    Related
    ENSRNOP00000026251.2, ENSRNOT00000026251.5
    Conserved Domains (2) summary
    cd08385
    Location:297 → 422
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:431 → 565
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    104017341..104032046
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063282293.1 → XP_063138363.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSR2, A6JAN7

  2. XM_039102286.2 → XP_038958214.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSR2, A6JAN7, B1AC44
    Conserved Domains (2) summary
    cd08385
    Location:297 → 422
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:431 → 565
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  3. XM_063282281.1 → XP_063138351.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSR2, A6JAN7

  4. XM_039102263.2 → XP_038958191.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSR2, A6JAN7, B1AC44
    Conserved Domains (2) summary
    cd08385
    Location:297 → 422
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:431 → 565
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  5. XM_039102277.1 → XP_038958205.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSR2, A6JAN7, B1AC44
    Conserved Domains (2) summary
    cd08385
    Location:297 → 422
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:431 → 565
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  6. XM_006228979.5 → XP_006229041.1  synaptotagmin-3 isoform X1

    See identical proteins and their annotated locations for XP_006229041.1

    UniProtKB/TrEMBL
    A0A0G2JSR2, A6JAN7, B1AC44
    Conserved Domains (2) summary
    cd08385
    Location:297 → 422
    C2A_Synaptotagmin-1-5-6-9-10; C2A domain first repeat present in Synaptotagmins 1, 5, 6, 9, and 10
    cd08403
    Location:431 → 565
    C2B_Synaptotagmin-3-5-6-9-10; C2 domain second repeat present in Synaptotagmins 3, 5, 6, 9, and 10

  7. XM_063282299.1 → XP_063138369.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSR2, A6JAN7

  8. XM_063282307.1 → XP_063138377.1  synaptotagmin-3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JSR2, A6JAN7
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P40748.1 GenPept UniProtKB/Swiss-Prot:P40748

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous