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Sdsl serine dehydratase-like [ Mus musculus (house mouse) ]

Gene ID: 257635, updated on 23-Jun-2021

Summary

Official Symbol
Sdslprovided by MGI
Official Full Name
serine dehydratase-likeprovided by MGI
Primary source
MGI:MGI:2182607
See related
Ensembl:ENSMUSG00000029596
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SDS; TDH; SDH1; SDS-RS1; AI504310; 4432411H13Rik
Expression
Broad expression in adrenal adult (RPKM 41.3), duodenum adult (RPKM 15.9) and 18 other tissues See more
Orthologs
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Genomic context

See Sdsl in Genome Data Viewer
Location:
5; 5 F
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (120596258..120610890, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (120458193..120472825, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (120908211..120922772, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 27199 Neighboring gene predicted gene, 31976 Neighboring gene LIM homeobox protein 5 Neighboring gene serine dehydratase Neighboring gene phospholipase B domain containing 2 Neighboring gene solute carrier family 8 (sodium/lithium/calcium exchanger), member B1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables L-serine ammonia-lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables L-threonine ammonia-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in threonine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 

General protein information

Preferred Names
serine dehydratase-like
Names
L-serine deaminase
L-serine dehydratase/L-threonine deaminase
L-threonine dehydratase
SDH
serine dehydratase related sequence 1
NP_001371183.1
NP_598663.2
XP_011246504.2
XP_036021034.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001384254.1NP_001371183.1  serine dehydratase-like

    Status: VALIDATED

    Source sequence(s)
    AC129553
    Related
    ENSMUSP00000031594.7, ENSMUST00000031594.13
    Conserved Domains (1) summary
    cd06448
    Location:17326
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
  2. NM_133902.3NP_598663.2  serine dehydratase-like

    See identical proteins and their annotated locations for NP_598663.2

    Status: VALIDATED

    Source sequence(s)
    AC129553
    Consensus CDS
    CCDS19618.1
    UniProtKB/Swiss-Prot
    Q8R238
    Related
    ENSMUSP00000058198.8, ENSMUST00000052258.14
    Conserved Domains (1) summary
    cd06448
    Location:17326
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    120596258..120610890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248202.2XP_011246504.2  serine dehydratase-like isoform X1

    UniProtKB/Swiss-Prot
    Q8R238
    Conserved Domains (1) summary
    cd06448
    Location:17326
    L-Ser-dehyd; Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- , D-serine, or L-threonine to pyruvate/ketobutyrate and ammonia.
  2. XM_036165141.1XP_036021034.1  serine dehydratase-like isoform X2

    Conserved Domains (1) summary
    cl00342
    Location:20274
    Trp-synth-beta_II; Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan ...
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