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CIZ1 CDKN1A interacting zinc finger protein 1 [ Homo sapiens (human) ]

Gene ID: 25792, updated on 5-Mar-2024

Summary

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Official Symbol
CIZ1provided by HGNC
Official Full Name
CDKN1A interacting zinc finger protein 1provided by HGNC
Primary source
HGNC:HGNC:16744
See related
Ensembl:ENSG00000148337 MIM:611420; AllianceGenome:HGNC:16744
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NP94; LSFR1; ZNF356
Summary
The protein encoded by this gene is a zinc finger DNA binding protein that interacts with CIP1, part of a complex with cyclin E. The encoded protein may regulate the cellular localization of CIP1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Expression
Ubiquitous expression in ovary (RPKM 30.0), testis (RPKM 29.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
9q34.11
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128166065..128204222, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140373145..140411302, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (130928344..130966501, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20327 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130916023-130916694 Neighboring gene MPRA-validated peak7335 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130920069-130920264 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr9:130921445-130922398 and GRCh37_chr9:130922399-130923352 Neighboring gene lipocalin 2 Neighboring gene bublin coiled coil protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130940513-130941204 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130953834-130954001 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130954889-130955404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:130955405-130955919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29074 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20331 Neighboring gene Sharpr-MPRA regulatory region 9989 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130966872-130967444 Neighboring gene dynamin 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr9:130980103-130981059 and GRCh37_chr9:130981060-130982015 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:130992962-130993210 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:130995155-130995654 Neighboring gene microRNA 199b Neighboring gene microRNA 3154

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CIZ1 knockdown suppresses the proliferation of bladder cancer cells by inducing apoptosis. Chen X, et al. Gene, 2019 Nov 30. PMID 31252164
  2. CIZ1 Expression Is Upregulated in Hemangioma of the Tongue. Wang Y, et al. Pathol Oncol Res, 2019 Oct. PMID 30456533
  3. CIZ1 is upregulated in hepatocellular carcinoma and promotes the growth and migration of the cancer cells. Wu J, et al. Tumour Biol, 2016 Apr. PMID 26515335
  4. Mutations in CIZ1 are not a major cause for dystonia in Germany. Dufke C, et al. Mov Disord, 2015 Apr 15. PMID 25778706
  5. CIZ1 promoted the growth and migration of gallbladder cancer cells. Zhang D, et al. Tumour Biol, 2015 Apr. PMID 25427641

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of lncRNA DANCR functions as an oncogenic role in non-small lung cancer by regulating miR-214-5p/CIZ1 axis.
    Title: Upregulation of lncRNA DANCR functions as an oncogenic role in non-small lung cancer by regulating miR-214-5p/CIZ1 axis.
  2. High CIZ1 expression is associated with Hemangioma of the Tongue.
    Title: CIZ1 Expression Is Upregulated in Hemangioma of the Tongue.
  3. silencing of CIZ1 suppressed bladder cancer cell proliferation through inducing apoptosis and reducing cell cycle progression
    Title: CIZ1 knockdown suppresses the proliferation of bladder cancer cells by inducing apoptosis.
  4. data reveal that CIZ1 plays a major role in ensuring stable association of Xist RNA within the Xi territory.
    Title: Repeat E anchors Xist RNA to the inactive X chromosomal compartment through CDKN1A-interacting protein (CIZ1).
  5. our study demonstrated that CIZ1 is a positive regulator of YAP signaling, and CIZ1 might be a therapeutic target for hepatocellular carcinoma
    Title: CIZ1 interacts with YAP and activates its transcriptional activity in hepatocellular carcinoma cells.
  6. CIZ1 activates YAP/TAZ signaling in human hepatocellular carcinoma cells.
    Title: CIZ1 is upregulated in hepatocellular carcinoma and promotes the growth and migration of the cancer cells.
  7. CIZ1 is a kinase sensor that promotes initiation of DNA replication at low kinase levels, when in a hypophosphorylated state that is permissive for cyclin-A-CDK2 interaction and delivery to licensed origins.
    Title: Cyclin-A-CDK2-mediated phosphorylation of CIZ1 blocks replisome formation and initiation of mammalian DNA replication.
  8. The results of this study showed CIZ1 will play a less important role in dystonia patient diagnosis than previously thought because variants of unclear significance are observed in approximately 1% of adult-onset sporadic dystonia patients in Germany.
    Title: Mutations in CIZ1 are not a major cause for dystonia in Germany.
  9. Our study demonstrated that CIZ1 played an oncogenic role in the progression of GBC and CIZ1 might be a promising target for the treatment of GBC
    Title: CIZ1 promoted the growth and migration of gallbladder cancer cells.
  10. This study suggested that No mutations in CIZ1 in twelve adult-onset primary cervical dystonia families.
    Title: No mutations in CIZ1 in twelve adult-onset primary cervical dystonia families.
Submit: New GeneRIF Correction See all GeneRIFs (19)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclin binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in maintenance of protein location in nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
cip1-interacting zinc finger protein
Names
nuclear protein NP94
zinc finger protein 356

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032983.1 RefSeqGene

    Range
    17812..43319
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001131015.2 → NP_001124487.1  cip1-interacting zinc finger protein isoform 2

    See identical proteins and their annotated locations for NP_001124487.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (2) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 5.
    Source sequence(s)
    AK023978, BC004119, BC021163
    Consensus CDS
    CCDS48034.1
    UniProtKB/TrEMBL
    B4E0A3
    Related
    ENSP00000362039.3, ENST00000372948.7
    Conserved Domains (4) summary
    smart00451
    Location:536 → 565
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:600 → 620
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:630 → 654
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl26464
    Location:117 → 426
    Atrophin-1; Atrophin-1 family

  2. NM_001131016.2 → NP_001124488.1  cip1-interacting zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_001124488.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) has an alternate exon in place of the first exon and lacks an alternate in-frame exon compared to variant 6. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5. Variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AK292713, AK303636, BC021163
    Consensus CDS
    CCDS6894.1
    UniProtKB/Swiss-Prot
    A8K9J8, B4E131, B7ZAS8, Q5SYW3, Q5SYW5, Q8WU72, Q9H868, Q9NYM8, Q9UHK4, Q9ULV3, Q9Y3F9, Q9Y3G0
    UniProtKB/TrEMBL
    B7Z3U7
    Related
    ENSP00000362029.5, ENST00000372938.10
    Conserved Domains (4) summary
    smart00451
    Location:592 → 621
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:656 → 676
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:686 → 710
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl26464
    Location:129 → 482
    Atrophin-1; Atrophin-1 family

  3. NM_001131017.2 → NP_001124489.1  cip1-interacting zinc finger protein isoform 3

    See identical proteins and their annotated locations for NP_001124489.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (3) is shorter at the N-terminus and lacks two alternate internal segments compared to isoform 5.
    Source sequence(s)
    AK303288, BC021163
    UniProtKB/TrEMBL
    B4E0A3
    Related
    ENSP00000498625.1, ENST00000651955.1
    Conserved Domains (4) summary
    smart00451
    Location:531 → 560
    ZnF_U1; U1-like zinc finger
    COG5112
    Location:605 → 656
    UFD2; U1-like Zn-finger-containing protein [General function prediction only]
    sd00020
    Location:595 → 615
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:625 → 649
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  4. NM_001131018.2 → NP_001124490.1  cip1-interacting zinc finger protein isoform 4

    See identical proteins and their annotated locations for NP_001124490.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) has an alternate exon in place of the first exon, lacks two alternate in-frame exons, and lacks an alternate in-frame segment compared to variant 6. The resulting isoform (4) is shorter at the N-terminus and lacks three alternate internal segments compared to isoform 5.
    Source sequence(s)
    BC021163, BM757318
    Consensus CDS
    CCDS48033.1
    UniProtKB/TrEMBL
    B4E0A3
    Related
    ENSP00000362045.1, ENST00000372954.5
    Conserved Domains (4) summary
    smart00451
    Location:512 → 541
    ZnF_U1; U1-like zinc finger
    COG5112
    Location:586 → 637
    UFD2; U1-like Zn-finger-containing protein [General function prediction only]
    sd00020
    Location:576 → 596
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:606 → 630
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  5. NM_001257975.2 → NP_001244904.1  cip1-interacting zinc finger protein isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) represents the longest transcript. The resulting isoform (5) may be the longest isoform; however, the N-terminus of this isoform is only predicted and not supported by experimental data.
    Source sequence(s)
    AK296363, AL590708, BC021163
    Consensus CDS
    CCDS75910.1
    UniProtKB/TrEMBL
    B7Z3U7, F5H2X7
    Related
    ENSP00000439244.2, ENST00000538431.5
    Conserved Domains (2) summary
    smart00451
    Location:622 → 651
    ZnF_U1; U1-like zinc finger
    pfam12171
    Location:742 → 766
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  6. NM_001257976.2 → NP_001244905.1  cip1-interacting zinc finger protein isoform 6

    See identical proteins and their annotated locations for NP_001244905.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has an alternate exon in place of the first exon, lacks an alternate in-frame exon, and lacks another alternate exon compared to variant 6, that causes a frameshift. The resulting isoform (6) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5.
    Source sequence(s)
    AK303636, AL590708, BC021163
    Consensus CDS
    CCDS59147.1
    UniProtKB/TrEMBL
    H0Y5D5
    Related
    ENSP00000486816.1, ENST00000629610.2
    Conserved Domains (4) summary
    smart00451
    Location:491 → 520
    ZnF_U1; U1-like zinc finger
    COG5112
    Location:565 → 616
    UFD2; U1-like Zn-finger-containing protein [General function prediction only]
    sd00020
    Location:555 → 575
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:585 → 609
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding

  7. NM_012127.3 → NP_036259.2  cip1-interacting zinc finger protein isoform 1

    See identical proteins and their annotated locations for NP_036259.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) has an alternate exon in place of the first exon and lacks an alternate in-frame exon compared to variant 6. The resulting isoform (1) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 5. Variants 1 and 5 encode the same isoform (1).
    Source sequence(s)
    AF159025, AK023978, BC021163
    Consensus CDS
    CCDS6894.1
    UniProtKB/Swiss-Prot
    A8K9J8, B4E131, B7ZAS8, Q5SYW3, Q5SYW5, Q8WU72, Q9H868, Q9NYM8, Q9UHK4, Q9ULV3, Q9Y3F9, Q9Y3G0
    UniProtKB/TrEMBL
    B7Z3U7
    Related
    ENSP00000489425.1, ENST00000634901.1
    Conserved Domains (4) summary
    smart00451
    Location:592 → 621
    ZnF_U1; U1-like zinc finger
    sd00020
    Location:656 → 676
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam12171
    Location:686 → 710
    zf-C2H2_jaz; Zinc-finger double-stranded RNA-binding
    cl26464
    Location:129 → 482
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    128166065..128204222 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    140373145..140411302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULV3.2 GenPept UniProtKB/Swiss-Prot:Q9ULV3

Gene LinkOut

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