PARM1 prostate androgen-regulated mucin-like protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: PARM1provided by HGNC
Official Full Name: prostate androgen-regulated mucin-like protein 1provided by HGNC
Primary source: HGNC:HGNC:24536
See related: Ensembl:ENSG00000169116 MIM:617688; AllianceGenome:HGNC:24536
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: WSC4; Cipar1; PARM-1; DKFZP564O0823
Summary: Predicted to be involved in positive regulation of telomerase activity. Located in several cellular components, including Golgi apparatus; endosome; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in thyroid (RPKM 83.3), colon (RPKM 61.9) and 21 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 4q13.3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	4	NC_000004.12 (74933116..75050113)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	4	NC_060928.1 (78273250..78390252)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	4	NC_000004.11 (75858326..75975323)

Chromosome 4 - NC_000004.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neurexophilin and PC-esterase domain family member 4 (NXPE4) and prostate androgen-regulated mucin-like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer.
Title: Neurexophilin and PC-esterase domain family member 4 (NXPE4) and prostate androgen-regulated mucin-like protein 1 (PARM1) as prognostic biomarkers for colorectal cancer.
Our results strongly suggest the oncogenic potential of PARM-1.
Title: Characterization and identification of PARM-1 as a new potential oncogene.
PARM1 does not play a major role in the development of epispadias
Title: Murine expression and mutation analyses of the prostate androgen-regulated mucin-like protein 1 (Parm1) gene, a candidate for human epispadias.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Ectopic expression of hPARM-1 in PC3 prostate cancer cells increased colony formation, suggesting a probable role in cell proliferation.
Title: Human PARM-1 is a novel mucin-like, androgen-regulated gene exhibiting proliferative effects in prostate cancer cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-22409 (e-PCR)
- UniSTS:82714

RH119553 (e-PCR)
- UniSTS:132636

A005X37 (e-PCR)
- UniSTS:6686

G20578 (e-PCR)
- UniSTS:6687

D4S773 (e-PCR)
- UniSTS:56653

D4S2887 (e-PCR)
- UniSTS:635

SHGC-36704 (e-PCR)
- UniSTS:73101

D4S2591E (e-PCR)
- UniSTS:150986

RH99328 (e-PCR)
- UniSTS:88794

NIB1435 (e-PCR)
- UniSTS:22241

RH119874 (e-PCR)
- UniSTS:133619

G20397 (e-PCR)
- UniSTS:79607

A005P21 (e-PCR)
- UniSTS:79608

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of telomerase activity	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: prostate androgen-regulated mucin-like protein 1

Names: WSC4, cell wall integrity and stress response component 4 homolog; castration-induced prostatic apoptosis-related protein 1; prostatic androgen-regulated mucin-like protein 1; prostatic androgen-repressed message 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_015393.4 → NP_056208.2 prostate androgen-regulated mucin-like protein 1 precursor

See identical proteins and their annotated locations for NP_056208.2

Status: VALIDATED

Source sequence(s)

AC098825, AC110760, AI767320

Consensus CDS

CCDS47077.1

UniProtKB/Swiss-Prot

B3KMQ9, Q6UWI2, Q96DV8, Q9Y4S1

Related

ENSP00000370224.3, ENST00000307428.7

Conserved Domains (1) summary

pfam17061
Location:15 → 310

PARM; PARM

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000004.12 Reference GRCh38.p14 Primary Assembly

Range

74933116..75050113

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011531833.1 → XP_011530135.1 prostate androgen-regulated mucin-like protein 1 isoform X1

Conserved Domains (1) summary

pfam17061
Location:50 → 345

PARM; PARM