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ARMC8 armadillo repeat containing 8 [ Homo sapiens (human) ]

Gene ID: 25852, updated on 23-Nov-2021

Summary

Official Symbol
ARMC8provided by HGNC
Official Full Name
armadillo repeat containing 8provided by HGNC
Primary source
HGNC:HGNC:24999
See related
Ensembl:ENSG00000114098 MIM:618521
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GID5; VID28; S863-2; HSPC056
Expression
Ubiquitous expression in bone marrow (RPKM 8.0), thyroid (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

See ARMC8 in Genome Data Viewer
Location:
3q22.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (138187248..138298389)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (137906090..138017231)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene alpha-1,4-N-acetylglucosaminyltransferase Neighboring gene debranching RNA lariats 1 Neighboring gene NME/NM23 family member 9 Neighboring gene muscle RAS oncogene homolog Neighboring gene uncharacterized LOC105374129

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC4880, MGC10058

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of GID complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in specific granule lumen TAS
Traceable Author Statement
more info
 
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
 
part_of ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
armadillo repeat-containing protein 8
Names
GID complex subunit 5, VID28 homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001267041.2NP_001253970.1  armadillo repeat-containing protein 8 isoform 3

    See identical proteins and their annotated locations for NP_001253970.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' and 3' UTRs and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform (3) is longer and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK296837, AK299769, AL096748, BQ014283, HY004298
    Consensus CDS
    CCDS58854.1
    UniProtKB/Swiss-Prot
    Q8IUR7
    UniProtKB/TrEMBL
    B7Z637
    Related
    ENSP00000441592.1, ENST00000538260.5
    Conserved Domains (4) summary
    COG5064
    Location:22181
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:343576
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:522552
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:5790
    ARM; armadillo repeat [structural motif]
  2. NM_001267042.3NP_001253971.1  armadillo repeat-containing protein 8 isoform 4

    See identical proteins and their annotated locations for NP_001253971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' and 3' UTRs and has multiple differences in the coding region, including the use of an alternate start codon, compared to variant 1. The encoded isoform (4) is longer and has distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AK296757, AL096748, BQ014283, CX167429
    Consensus CDS
    CCDS58853.1
    UniProtKB/Swiss-Prot
    Q8IUR7
    Related
    ENSP00000420706.1, ENST00000461822.5
    Conserved Domains (4) summary
    COG5064
    Location:28414
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:307540
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:486516
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:5790
    ARM; armadillo repeat [structural motif]
  3. NM_001282342.2NP_001269271.1  armadillo repeat-containing protein 8 isoform 5

    See identical proteins and their annotated locations for NP_001269271.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' and 3' UTRs and has multiple differences in the coding region, including the use of a downstream start codon, compared to variant 1. The encoded isoform (5) is longer and has a shorter N-terminus and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK299769, AL096748, BQ014283
    Consensus CDS
    CCDS75020.1
    UniProtKB/Swiss-Prot
    Q8IUR7
    UniProtKB/TrEMBL
    B7Z637
    Related
    ENSP00000417049.1, ENST00000485396.5
    Conserved Domains (4) summary
    COG5064
    Location:3139
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:301534
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:480510
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:1548
    ARM; armadillo repeat [structural motif]
  4. NM_001363941.2NP_001350870.1  armadillo repeat-containing protein 8 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC022337, AC068777
    Consensus CDS
    CCDS87139.1
    Related
    ENSP00000419413.1, ENST00000469044.6
    Conserved Domains (4) summary
    COG5064
    Location:49212
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:374607
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:553583
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:5790
    ARM; armadillo repeat [structural motif]
  5. NM_001363942.1NP_001350871.1  armadillo repeat-containing protein 8 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC022337, AC068777
    Consensus CDS
    CCDS87140.1
    Conserved Domains (4) summary
    COG5064
    Location:7170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:332565
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:511541
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:1548
    ARM; armadillo repeat [structural motif]
  6. NM_014154.4NP_054873.2  armadillo repeat-containing protein 8 isoform 1

    See identical proteins and their annotated locations for NP_054873.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the shortest isoform (1). Variants 1 and 3 encode the same isoform.
    Source sequence(s)
    AK289577, BC013424, DC342329, HY004298
    Consensus CDS
    CCDS3098.1
    UniProtKB/Swiss-Prot
    Q8IUR7
    Related
    ENSP00000420440.1, ENST00000471453.5
    Conserved Domains (2) summary
    COG5064
    Location:35198
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:4376
    ARM; armadillo repeat [structural motif]
  7. NM_015396.6NP_056211.2  armadillo repeat-containing protein 8 isoform 2

    See identical proteins and their annotated locations for NP_056211.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes multiple additional exons in the coding region and differs in the 3' UTR, compared to variant 1. The encoded isoform (2) is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL096748, BC041699, BQ014283, HY004298
    Consensus CDS
    CCDS54646.1
    UniProtKB/Swiss-Prot
    Q8IUR7
    Related
    ENSP00000420333.1, ENST00000481646.5
    Conserved Domains (4) summary
    COG5064
    Location:35198
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:360593
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:539569
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:4376
    ARM; armadillo repeat [structural motif]
  8. NM_213654.3NP_998819.1  armadillo repeat-containing protein 8 isoform 1

    See identical proteins and their annotated locations for NP_998819.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' UTR, compared to variant 1. Variants 1 and 3 encode the same isoform (1).
    Source sequence(s)
    BC013424, HY004298
    Consensus CDS
    CCDS3098.1
    UniProtKB/Swiss-Prot
    Q8IUR7
    Related
    ENSP00000351221.2, ENST00000358441.6
    Conserved Domains (2) summary
    COG5064
    Location:35198
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    sd00043
    Location:4376
    ARM; armadillo repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    138187248..138298389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006100.2XP_016861589.1  armadillo repeat-containing protein 8 isoform X7

  2. XM_006713566.4XP_006713629.1  armadillo repeat-containing protein 8 isoform X3

    See identical proteins and their annotated locations for XP_006713629.1

    UniProtKB/Swiss-Prot
    Q8IUR7
    Conserved Domains (4) summary
    COG5064
    Location:7170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:332565
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:511541
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:1548
    ARM; armadillo repeat [structural motif]
  3. XM_017006097.1XP_016861586.1  armadillo repeat-containing protein 8 isoform X6

  4. XM_011512632.1XP_011510934.1  armadillo repeat-containing protein 8 isoform X3

    See identical proteins and their annotated locations for XP_011510934.1

    UniProtKB/Swiss-Prot
    Q8IUR7
    Related
    ENSP00000417304.1, ENST00000491704.5
    Conserved Domains (4) summary
    COG5064
    Location:7170
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:332565
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:511541
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:1548
    ARM; armadillo repeat [structural motif]
  5. XM_024453441.1XP_024309209.1  armadillo repeat-containing protein 8 isoform X4

    Conserved Domains (4) summary
    COG5369
    Location:329562
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:508538
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:4376
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:8167
    Arm_3; Atypical Arm repeat
  6. XM_017006098.2XP_016861587.1  armadillo repeat-containing protein 8 isoform X6

  7. XM_017006099.1XP_016861588.1  armadillo repeat-containing protein 8 isoform X6

  8. XM_017006095.2XP_016861584.1  armadillo repeat-containing protein 8 isoform X5

    Conserved Domains (4) summary
    COG5369
    Location:293526
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:472502
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:4376
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:14400
    Arm_3; Atypical Arm repeat
  9. XM_006713565.2XP_006713628.1  armadillo repeat-containing protein 8 isoform X2

    See identical proteins and their annotated locations for XP_006713628.1

    UniProtKB/Swiss-Prot
    Q8IUR7
    Conserved Domains (4) summary
    COG5064
    Location:35198
    SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
    COG5369
    Location:360593
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:539569
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:4376
    ARM; armadillo repeat [structural motif]
  10. XM_024453442.1XP_024309210.1  armadillo repeat-containing protein 8 isoform X5

    Conserved Domains (4) summary
    COG5369
    Location:293526
    COG5369; Uncharacterized conserved protein [Function unknown]
    sd00044
    Location:472502
    HEAT; HEAT repeat [structural motif]
    sd00043
    Location:4376
    ARM; armadillo repeat [structural motif]
    cl25709
    Location:14400
    Arm_3; Atypical Arm repeat

RNA

  1. XR_001740086.1 RNA Sequence

  2. XR_002959505.1 RNA Sequence

  3. XR_002959506.1 RNA Sequence

  4. XR_001740087.2 RNA Sequence

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