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Kcnip4 potassium voltage-gated channel interacting protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 259243, updated on 11-Apr-2024

Summary

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Official Symbol
Kcnip4provided by RGD
Official Full Name
potassium voltage-gated channel interacting protein 4provided by RGD
Primary source
RGD:708539
See related
Ensembl:ENSRNOG00000032350 AllianceGenome:RGD:708539
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kchip4
Summary
Enables potassium channel regulator activity. Involved in protein localization to plasma membrane and regulation of potassium ion transmembrane transport. Located in several cellular components, including cytosol; dendrite; and neuronal cell body. Part of voltage-gated potassium channel complex. Orthologous to human KCNIP4 (potassium voltage-gated channel interacting protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 158.8), Uterus (RPKM 43.9) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
14q11
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (65593297..66743994)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (61380699..62531399)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (65549362..66749181)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene galectin 9, pseudogene 2 Neighboring gene interferon induced transmembrane protein3, pseudogene 1 Neighboring gene uncharacterized LOC134481849 Neighboring gene chaperonin containing TCP1 subunit 6A, pseudogene 18 Neighboring gene dyskerin pseudouridine synthase 1, pseudogene 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1, pseudogene 20 Neighboring gene parkin coregulated like Neighboring gene slit guidance ligand 2 Neighboring gene microRNA 218-1 Neighboring gene microRNA 3565

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity. Su ZJ, et al. J Neurochem, 2020 Jun. PMID 31792968
  2. Regulation of KChIP2 potassium channel beta subunit gene expression underlies the gradient of transient outward current in canine and human ventricle. Rosati B, et al. J Physiol, 2001 May 15. PMID 11351020, Free PMC Article
  3. Structural Insights into KChIP4a Modulation of Kv4.3 Inactivation. Liang P, et al. J Biol Chem, 2009 Feb 20. PMID 19109250
  4. The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level. Kitazawa M, et al. J Biol Chem, 2014 Jun 20. PMID 24811166, Free PMC Article
  5. Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis. Rainnie DG, et al. J Comp Neurol, 2014 Feb 15. PMID 24037673, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity.
    Title: Down-regulation of miR-3068-3p enhances kcnip4-regulated A-type potassium current to protect against glutamate-induced excitotoxicity.
  2. Subunit counting by single-molecule imaging revealed that the bound number of KChIP4 in each Kv4.2.KChIP4 complex was dependent on the expression level of KChIP4.
    Title: The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression level.
  3. This study demonistrared that the expression and function of KCHIP4 channels in neurons of the rat bed nucleus of the stria terminalis.
    Title: Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.
  4. KChIP4a isoform, which exhibits unique effects on Kv4 channel gating negatively influences the impact of other KChIPs
    Title: A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels.
  5. KChIP4 coassociates with Kv4 subunits in hippocampal membranes, confirming that the KChIPs are tightly associated with Kv4 subunits in native brain A-type channel complexes which may play a major role as modulators of somatodendritic excitability.
    Title: KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of potassium ion transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISO
Inferred from Sequence Orthology
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of voltage-gated potassium channel complex IEA
Inferred from Electronic Annotation
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Kv channel-interacting protein 4
Names
A-type potassium channel modulatory protein 4
Kv channel interacting protein 4
potassium channel-interacting protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181365.2 → NP_852030.1  Kv channel-interacting protein 4

    See identical proteins and their annotated locations for NP_852030.1

    Status: PROVISIONAL

    Source sequence(s)
    AF345444
    UniProtKB/Swiss-Prot
    Q99MG8, Q99MG9
    UniProtKB/TrEMBL
    G3V9C1
    Related
    ENSRNOP00000042016.6, ENSRNOT00000049743.5
    Conserved Domains (1) summary
    COG5126
    Location:80 → 239
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    65593297..66743994
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063272886.1 → XP_063128956.1  Kv channel-interacting protein 4 isoform X1

    UniProtKB/TrEMBL
    A6IJJ6

  2. XM_017599089.3 → XP_017454578.1  Kv channel-interacting protein 4 isoform X5

    UniProtKB/TrEMBL
    G3V9C1
    Related
    ENSRNOP00000075583.2
    Conserved Domains (1) summary
    COG5126
    Location:46 → 205
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  3. XM_017599088.3 → XP_017454577.1  Kv channel-interacting protein 4 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZMG1, G3V9C1
    Related
    ENSRNOP00000079125.1
    Conserved Domains (1) summary
    COG5126
    Location:55 → 214
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  4. XM_017599087.3 → XP_017454576.1  Kv channel-interacting protein 4 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A8J8, G3V9C1
    Related
    ENSRNOP00000089378.1
    Conserved Domains (1) summary
    COG5126
    Location:59 → 218
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  5. XM_017599086.3 → XP_017454575.1  Kv channel-interacting protein 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZSB5, G3V9C1
    Related
    ENSRNOP00000081482.1
    Conserved Domains (1) summary
    COG5126
    Location:63 → 222
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

  6. XM_063272887.1 → XP_063128957.1  Kv channel-interacting protein 4 isoform X6

    UniProtKB/TrEMBL
    A0A0G2KAZ2, A6IJJ8
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MG9.1 GenPept UniProtKB/Swiss-Prot:Q99MG9

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