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Obp3 alpha-2u globulin PGCL4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 259247, updated on 13-Apr-2024

Summary

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Symbol
Obp3provided by RGD
Full Name
alpha-2u globulin PGCL4provided by RGD
Primary source
RGD:708508
See related
Ensembl:ENSRNOG00000065108 AllianceGenome:RGD:708508
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables odorant binding activity. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 13981.1) See more
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Genomic context

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Location:
5q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (79637234..79640810, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (74842316..74845858, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (77313357..77316875, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene sorting nexin family member 30 Neighboring gene transfer RNA alanine (anticodon AGC) 81 Neighboring gene solute carrier family 46, member 2 Neighboring gene zinc finger protein 37, pseudogene 6 Neighboring gene major urinary protein 4 like 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. α2u-globulins mediate manipulation of host attractiveness in Toxoplasma gondii-Rattus novergicus association. Vasudevan A, et al. ISME J, 2015 Sep. PMID 25853804, Free PMC Article
  2. The major urinary protein system in the rat. Gómez-Baena G, et al. Biochem Soc Trans, 2014 Aug. PMID 25109974
  3. Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3. Portman KL, et al. Biochemistry, 2014 Apr 15. PMID 24665925
  4. Down-regulation of alpha-2u globulin in renal mitochondria of STZ-induced diabetic rats observed by a proteomic method. Sun SH, et al. Ann Endocrinol (Paris), 2012 Dec. PMID 23131471
  5. Dynamics of odorant binding to thin aqueous films of rat-OBP3. Yabuki M, et al. Chem Senses, 2011 Sep. PMID 21536621

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. T. gondii infection enhances hepatic production and urinary excretion of alpha2u-globulins in rats; alpha2u-globulins are sufficient to recapitulate male sexual attractiveness akin to effects of the infection
    Title: α2u-globulins mediate manipulation of host attractiveness in Toxoplasma gondii-Rattus novergicus association.
  2. Obp3 binding energetics are modulated by two desolvation processes with quite different thermodynamic signatures
    Title: Enthalpy/entropy compensation effects from cavity desolvation underpin broad ligand binding selectivity for rat odorant binding protein 3.
  3. Down-regulation of alpha-2u globulin in renal mitochondria of STZ-induced diabetic rats.
    Title: Down-regulation of alpha-2u globulin in renal mitochondria of STZ-induced diabetic rats observed by a proteomic method.
  4. Because rat-OBP3 exhibits typical odorant-binding characteristics, the results not only provide fundamental information on the kinetics of odorant mass transfer induced by the presence of OBPs in the olfactory mucus layer but also support the possibility that vertebrate OBPs may facilitate the accumulation of odorants in the olfactory epithelium
    Title: Dynamics of odorant binding to thin aqueous films of rat-OBP3.
  5. The ligand profile for three odorant binding proteins (OBPs) of the rat have been determined using a large number of odorous compounds from different chemical classes.
    Title: Odorants of different chemical classes interact with distinct odorant binding protein subtypes.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC108576

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables odorant binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pheromone binding IEA
Inferred from Electronic Annotation
more info
  
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-2u globulin PGCL4
Names
alpha2 urinary globulin
major urinary protein-like
odorant-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033958.2 → NP_001029130.2  alpha-2u globulin PGCL4 precursor

    See identical proteins and their annotated locations for NP_001029130.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR compared to variant 1. Variant 1, 2, and 3 encode the same protein.
    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14
    Conserved Domains (1) summary
    cd19428
    Location:26 → 179
    lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

  2. NM_001033959.2 → NP_001029131.1  alpha-2u globulin PGCL4 precursor

    See identical proteins and their annotated locations for NP_001029131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR compared to variant 1. Variant 1, 2, and 3 encode the same protein.
    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14
    Conserved Domains (1) summary
    cd19428
    Location:26 → 179
    lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

  3. NM_147215.2 → NP_671748.2  alpha-2u globulin PGCL4 precursor

    See identical proteins and their annotated locations for NP_671748.2

    Status: VALIDATED

    Description
    Transcript Variant: The variant (1) represents the longest transcript. Variant 1, 2, and 3 encode the same protein.
    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14
    Related
    ENSRNOP00000048604.6, ENSRNOT00000043056.7
    Conserved Domains (1) summary
    cd19428
    Location:26 → 179
    lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    79637234..79640810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109326.2 → XP_038965254.1  alpha-2u globulin PGCL4 isoform X2

    UniProtKB/TrEMBL
    A0A9K3Y8C3, F8WFF8, Q63022, Q63213, Q78E14
    Conserved Domains (1) summary
    cd19428
    Location:26 → 179
    lipocalin_MUP-like; major urinary proteins (MUPs) and similar proteins

  2. XM_063287204.1 → XP_063143274.1  alpha-2u globulin PGCL4 isoform X1

Nucleotide Protein Strain
Heading Accession and Version

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