Leap2 liver-expressed antimicrobial peptide 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Leap2provided by MGI
Official Full Name: liver-expressed antimicrobial peptide 2provided by MGI
Primary source: MGI:MGI:2672795
See related: Ensembl:ENSMUSG00000036216 AllianceGenome:MGI:2672795
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: leap-2
Summary: Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide and defense response to fungus. Predicted to act upstream of or within defense response to bacterium. Predicted to be located in extracellular region. Orthologous to human LEAP2 (liver enriched antimicrobial peptide 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in duodenum adult (RPKM 48.2), liver adult (RPKM 44.4) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.3; 11 31.94 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (53313008..53313963, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (53422181..53423136, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of LEAP-2 alleviates obesity-induced myocardial injury by regulating macrophage polarization.
Title: Loss of LEAP-2 alleviates obesity-induced myocardial injury by regulating macrophage polarization.
The dietary regulation of LEAP2 depends on meal composition in mice.
Title: The dietary regulation of LEAP2 depends on meal composition in mice.
GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.
Title: GHSR controls food deprivation-induced activation of CRF neurons of the hypothalamic paraventricular nucleus in a LEAP2-dependent manner.
LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner.
Title: LEAP-2 Counteracts Ghrelin-Induced Food Intake in a Nutrient, Growth Hormone and Age Independent Manner.
LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue.
Title: LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue.
Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model.
Title: Growth hormone secretagogue receptor signalling affects high-fat intake independently of plasma levels of ghrelin and LEAP2, in a 4-day binge eating model.
plasma LEAP2/acyl-ghrelin molar ratio may be a key determinant modulating acyl-ghrelin activity in response to body mass, feeding status, and blood glucose.
Title: LEAP2 changes with body mass and food intake in humans and mice.
liver-expressed antimicrobial peptide 2 (LEAP2) is an endogenous antagonist of GHSR.
Title: LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)
Endonuclease-mediated (8) 1 citation

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to bacterium	IEA Inferred from Electronic Annotation more info
involved_in defense response to fungus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: liver-expressed antimicrobial peptide 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.