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RNF167 ring finger protein 167 [ Homo sapiens (human) ]

Gene ID: 26001, updated on 5-Mar-2024

Summary

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Official Symbol
RNF167provided by HGNC
Official Full Name
ring finger protein 167provided by HGNC
Primary source
HGNC:HGNC:24544
See related
Ensembl:ENSG00000108523 MIM:610431; AllianceGenome:HGNC:24544
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LP2254; RING105; 5730408C10Rik
Summary
RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 26.0), thyroid (RPKM 24.0) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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See RNF167 in Genome Data Viewer
Location:
17p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (4940092..4945222)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (4830440..4835570)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4843387..4848517)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11554 Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4841097-4841622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4841623-4842148 Neighboring gene solute carrier family 25 member 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4842149-4842674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11555 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:4843813-4844007 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11556 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:4847507-4848050 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11558 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11559 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11561 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8053 Neighboring gene profilin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8054 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8055 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 11562 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8057 Neighboring gene enolase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:4854946-4855680

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Naturally occurring and tumor-associated variants of RNF167 promote lysosomal exocytosis and plasma membrane resealing. Nair SV, et al. J Cell Sci, 2020 Jun 11. PMID 32409562
  2. RNF167 targets Arl8B for degradation to regulate lysosome positioning and endocytic trafficking. Deshar R, et al. FEBS J, 2016 Dec. PMID 27808481
  3. Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization. van Dijk JR, et al. Biochem J, 2014 Apr 1. PMID 24387786
  4. Membrane Targeting and GTPase Activity of Rab7 Are Required for Its Ubiquitination by RNF167. Ghilarducci K, et al. Int J Mol Sci, 2022 Jul 16. PMID 35887194, Free PMC Article
  5. RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation. Li T, et al. Nat Commun, 2021 Feb 16. PMID 33594058, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
    Title: E3 ligase RNF167 and deubiquitinase STAMBPL1 modulate mTOR and cancer progression.
  2. Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.
    Title: Functional interaction of ubiquitin ligase RNF167 with UBE2D1 and UBE2N promotes ubiquitination of AMPA receptor.
  3. RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
    Title: RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation.
  4. Data indicate that E3 ubiquitin-protein ligase RNF167 ubiquitinates Arl8B at the lysine residue K141 and reduces the level of the ADP-ribosylation factor-like 8B Arl8B protein.
    Title: RNF167 targets Arl8B for degradation to regulate lysosome positioning and endocytic trafficking.
  5. Point mutations are characterized in the RING domain of RNF167 and RNF13.
    Title: Tumour-associated mutations of PA-TM-RING ubiquitin ligases RNF167/RNF13 identify the PA domain as a determinant for endosomal localization.
  6. mutation of the Godzilla ubiquitylation target lysines on VAMP3 abrogates the formation of enlarged endosomes induced by either Godzilla or RNF167.
    Title: Goliath family E3 ligases regulate the recycling endosome pathway via VAMP3 ubiquitylation.
  7. RNF167 is a selective regulator of AMPAR-mediated neurotransmission.
    Title: Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp566H073

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to leucine starvation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of lysosome localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lysosome localization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organelle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of TORC1 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K29-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein K63-linked ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of synaptic transmission, glutamatergic IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
is_active_in endolysosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosomal membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF167
Names
RING-type E3 ubiquitin transferase RNF167
NP_001307285.1
NP_001307286.1
NP_001307287.1
NP_001307288.1
NP_001307289.1
NP_001307290.1
NP_001307291.1
NP_001307292.1
NP_001307293.1
NP_001307294.1
NP_001357232.1
NP_001357233.1
NP_001357234.1
NP_001357235.1
NP_001357236.1
NP_001357237.1
NP_001357240.1
NP_001357242.1
NP_001362414.1
NP_056343.1
XP_047291686.1
XP_054171650.1
XP_054171651.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320356.2 → NP_001307285.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
    Related
    ENSP00000459324.1, ENST00000571816.5
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228 → 273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  2. NM_001320357.2 → NP_001307286.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228 → 273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  3. NM_001320358.2 → NP_001307287.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228 → 273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  4. NM_001320359.2 → NP_001307288.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
    Related
    ENSP00000458794.1, ENST00000572430.5
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228 → 273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  5. NM_001320360.2 → NP_001307289.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228 → 273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  6. NM_001320361.2 → NP_001307290.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228 → 273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  7. NM_001320362.2 → NP_001307291.1  E3 ubiquitin-protein ligase RNF167 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS82040.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    UniProtKB/TrEMBL
    I3L0L6
    Conserved Domains (2) summary
    cd02123
    Location:1 → 135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193 → 238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  8. NM_001320363.2 → NP_001307292.1  E3 ubiquitin-protein ligase RNF167 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS82040.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    UniProtKB/TrEMBL
    I3L0L6
    Conserved Domains (2) summary
    cd02123
    Location:1 → 135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193 → 238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  9. NM_001320364.2 → NP_001307293.1  E3 ubiquitin-protein ligase RNF167 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS82040.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    UniProtKB/TrEMBL
    I3L0L6
    Conserved Domains (2) summary
    cd02123
    Location:1 → 135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193 → 238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  10. NM_001320365.2 → NP_001307294.1  E3 ubiquitin-protein ligase RNF167 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS82040.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    UniProtKB/TrEMBL
    I3L0L6
    Related
    ENSP00000458189.1, ENST00000576229.5
    Conserved Domains (2) summary
    cd02123
    Location:1 → 135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193 → 238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  11. NM_001370303.1 → NP_001357232.1  E3 ubiquitin-protein ligase RNF167 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:252 → 297
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  12. NM_001370304.1 → NP_001357233.1  E3 ubiquitin-protein ligase RNF167 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:252 → 297
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  13. NM_001370305.1 → NP_001357234.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228 → 273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  14. NM_001370306.1 → NP_001357235.1  E3 ubiquitin-protein ligase RNF167 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:227 → 272
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  15. NM_001370307.1 → NP_001357236.1  E3 ubiquitin-protein ligase RNF167 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:227 → 272
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  16. NM_001370308.1 → NP_001357237.1  E3 ubiquitin-protein ligase RNF167 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:1 → 135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:217 → 262
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  17. NM_001370311.1 → NP_001357240.1  E3 ubiquitin-protein ligase RNF167 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS82040.1
    Conserved Domains (2) summary
    cd02123
    Location:1 → 135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193 → 238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  18. NM_001370313.1 → NP_001357242.1  E3 ubiquitin-protein ligase RNF167 isoform f

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd16797
    Location:186 → 231
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
    cl28883
    Location:20 → 128
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...

  19. NM_001375485.1 → NP_001362414.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
    Related
    ENSP00000460190.1, ENST00000575111.5
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228 → 273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

  20. NM_015528.3 → NP_056343.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    See identical proteins and their annotated locations for NP_056343.1

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
    Related
    ENSP00000262482.6, ENST00000262482.11
    Conserved Domains (2) summary
    cd02123
    Location:20 → 170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228 → 273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    4940092..4945222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047435730.1 → XP_047291686.1  E3 ubiquitin-protein ligase RNF167 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    4830440..4835570
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054315676.1 → XP_054171651.1  E3 ubiquitin-protein ligase RNF167 isoform X1

  2. XM_054315675.1 → XP_054171650.1  E3 ubiquitin-protein ligase RNF167 isoform X2

    UniProtKB/Swiss-Prot
    D3DTK8, I3L0L6, Q6XYE0, Q8NDC1, Q9H6Y7, Q9Y3V1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H6Y7.1 GenPept UniProtKB/Swiss-Prot:Q9H6Y7

Gene LinkOut

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