mev-1 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Gene symbol: mev-1
Gene description: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial
Primary source: WormBase:WBGene00003225
Locus tag: CELE_T07C4.7
See related: AllianceGenome:WB:WBGene00003225
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable heme binding activity. Involved in several processes, including defense response to other organism; mitochondrial electron transport, succinate to ubiquinone; and regulation of response to oxidative stress. Located in mitochondrion. Human ortholog(s) of this gene implicated in Carney-Stratakis syndrome; gastrointestinal stromal tumor; lung non-small cell carcinoma; and paraganglioma. Orthologous to human SDHC (succinate dehydrogenase complex subunit C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (10334277..10335168)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We find that mev-1 mutants cannot respond adequately to increased energy demands, suggesting that oxidative phosphorylation is more severely impaired in these animals than has previously been appreciated.
Title: Identification of a previously undetected metabolic defect in the Complex II Caenorhabditis elegans mev-1 mutant strain using respiratory control analysis.
In conclusion, we identified PEK-1 as a mediator of hormesis in the mev-1 mutant of C. elegans which is induced by simultaneous inhibition of XBP-1 and its splicing activator IRE-1 and mediated through activation of the proteasome.
Title: PEK-1 is crucial for hormesis induced by inhibition of the IRE-1/XBP-1 pathway in the Caenorhabditis elegans mev-1 mutant.
MEV-1 as a key regulatory component for determining genetic responsiveness to oxidant/antioxidant imbalance that is associated with innate immunity
Title: Molecular mechanisms of resistance to human pathogenic bacteria in Caenorhabditis elegans by MEV-1 mediated oxidative stress.
Increase of glucose in mev-1 mutant of C elegans reduced the lifespan of the nematodes without affecting classic markers of aging
Title: Impairment of the proteasome is crucial for glucose-induced lifespan reduction in the mev-1 mutant of Caenorhabditis elegans.
the crystal structure of antiapoptotic CED-9 reveals a unique C-terminal helix altering the common BH3-binding region; the binding of EGL-1 to CED-9 is extremely stable
Title: Unique structural features of a BCL-2 family protein CED-9 and biophysical characterization of CED-9/EGL-1 interactions.
While we confirmed the ability of CED-9 to inhibit CED-4, our data argue that CED-9 can not directly inhibit CED-3.
Title: The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast.
Cyt-1 has a role in mitochondrial structure, and ced-3- and ced-4-dependent apoptosis and aging
Title: A complex II defect affects mitochondrial structure, leading to ced-3- and ced-4-dependent apoptosis and aging.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T07C4.7 (e-PCR)
- UniSTS:321049

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables electron transfer activity	IEA Inferred from Electronic Annotation more info
enables heme binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-CH group of donors	IEA Inferred from Electronic Annotation more info
contributes_to succinate dehydrogenase (quinone) activity	IDA Inferred from Direct Assay more info	PubMed
enables succinate dehydrogenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitochondrial electron transport, succinate to ubiquinone	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, succinate to ubiquinone	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of response to oxidative stress	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of succinate dehydrogenase complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

NP_001299884.1

Partially confirmed by transcript evidence

NP_001366681.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

10334277..10335168

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001379891.2 → NP_001366681.1 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

P41956

Conserved Domains (1) summary

cd03499
Location:52 → 171

SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...
NM_001312955.3 → NP_001299884.1 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AU58

Conserved Domains (1) summary

cd03499
Location:1 → 104

SQR_TypeC_SdhC; Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the ...