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DECR2 2,4-dienoyl-CoA reductase 2 [ Homo sapiens (human) ]

Gene ID: 26063, updated on 10-Mar-2024

Summary

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Official Symbol
DECR2provided by HGNC
Official Full Name
2,4-dienoyl-CoA reductase 2provided by HGNC
Primary source
HGNC:HGNC:2754
See related
Ensembl:ENSG00000242612 MIM:615839; AllianceGenome:HGNC:2754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDCR; SDR17C1
Summary
Enables 2,4-dienoyl-CoA reductase (NADPH) activity and trans-2-enoyl-CoA reductase (NADPH) activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in peroxisome. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in kidney (RPKM 18.7), liver (RPKM 15.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (401885..412482)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (398130..408668)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (451885..462482)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100134368 Neighboring gene post-GPI attachment to proteins 6 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:440484-440661 Neighboring gene ribosomal protein L23a pseudogene 5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10204 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:449109-449694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:450865-451450 Neighboring gene NME/NM23 nucleoside diphosphate kinase 4 Neighboring gene RAB11 family interacting protein 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:492123-492661 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:495322-495822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:495823-496323 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:516240-516869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:516870-517498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:532003-532508 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:534533-535038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:535039-535544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:537093-537971 Neighboring gene uncharacterized LOC107987417 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:542303-542924 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:544383-544961 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:544962-545539 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:576271-576832 Neighboring gene long intergenic non-protein coding RNA 235

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterisation of human peroxisomal 2,4-dienoyl-CoA reductase. De Nys K, et al. Biochim Biophys Acta, 2001 Aug 29. PMID 11514237
  2. Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs. Das AK, et al. J Biol Chem, 2000 Aug 11. PMID 10811639
  3. Identification of Peroxisomal Protein Complexes with PTS Receptors, Pex5 and Pex7, in Mammalian Cells. Okumoto K, et al. Subcell Biochem, 2018. PMID 30378028
  4. Two proteases, trypsin domain-containing 1 (Tysnd1) and peroxisomal lon protease (PsLon), cooperatively regulate fatty acid β-oxidation in peroxisomal matrix. Okumoto K, et al. J Biol Chem, 2011 Dec 30. PMID 22002062, Free PMC Article
  5. The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex. Khan MH, et al. J Cell Sci, 2017 Sep 15. PMID 28775156, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Peroxisomal beta-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer.
    Title: Peroxisomal β-oxidation enzyme, DECR2, regulates lipid metabolism and promotes treatment resistance in advanced prostate cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: NME4

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2,4-dienoyl-CoA reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 2,4-dienoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables trans-2-enoyl-CoA reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables trans-2-enoyl-CoA reductase (NADPH) activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation using acyl-CoA oxidase TAS
Traceable Author Statement
more info
  
involved_in fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in unsaturated fatty acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in peroxisomal membrane TAS
Traceable Author Statement
more info
  
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]
Names
2,4-dienoyl-CoA reductase 2, peroxisomal
peroxisomal 2,4-dienoyl-CoA reductase
short chain dehydrogenase/reductase family 17C member 1
NP_065715.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020664.4 → NP_065715.1  peroxisomal 2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing]

    See identical proteins and their annotated locations for NP_065715.1

    Status: VALIDATED

    Source sequence(s)
    BC010740, BC030226
    Consensus CDS
    CCDS10409.1
    UniProtKB/Swiss-Prot
    Q6ZRS7, Q96ET0, Q9NUI1
    UniProtKB/TrEMBL
    Q4VXZ8
    Related
    ENSP00000219481.5, ENST00000219481.10
    Conserved Domains (1) summary
    cd05369
    Location:26 → 273
    TER_DECR_SDR_a; Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    401885..412482
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187610.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1031..11628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    398130..408668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NUI1.1 GenPept UniProtKB/Swiss-Prot:Q9NUI1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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