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kl-3 male fertility factor kl3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 26067053, updated on 5-Jan-2022

Summary

Official Symbol
kl-3provided by FlyBase
Official Full Name
male fertility factor kl3provided by FlyBase
Primary source
FLYBASE:FBgn0267432
Locus tag
Dmel_CG45785
Gene type
protein coding
RNA name
male fertility factor kl3
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17629; CG40443; CG40936; CG40992; CG45785; DHC4A; Dmel\CG45785; Kl-3; kl-4; kl3; Kl3-Y; Lms3; ms(Y)104b; Y104b
Old locus tag
Dmel_CG17629; Dmel_CG40936; Dmel_CG40992
Summary
Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement and outer dynein arm assembly. Part of axonemal dynein complex. Is expressed in adult head; spermatogonium; and spermatozoon. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5). [provided by Alliance of Genome Resources, Nov 2021]
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Genomic context

See kl-3 in Genome Data Viewer
Location:
h8-h8
Exon count:
16
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) Y NC_024512.1 (336381..563165)

Chromosome Y - NC_024512.1Genomic Context describing neighboring genes Neighboring gene polycystine-related-Y Neighboring gene pseudo Neighboring gene pseudo Neighboring gene male fertility factor kl2 Neighboring gene Aldehyde reductase Y

Genomic regions, transcripts, and products

Genomic Sequence:
NC_024512.1 Chromosome Y Reference Release 6 plus ISO1 MT Primary Assembly

General gene information

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables dynein intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables dynein light intermediate chain binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables minus-end-directed microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables minus-end-directed microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in cilium movement ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of axonemal dynein complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of outer dynein arm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of outer dynein arm ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
male fertility factor kl3
Names
CG45785-PC
gamma-dynein heavy chain
kl-3-PC
male fertility factor kl-3
NP_001104482.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_024512.1 Reference assembly

    Range
    336381..563165
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001111012.3NP_001104482.3  male fertility factor kl3 [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8Y5B7
    Related
    FBpp0312366, FBtr0346771
    Conserved Domains (6) summary
    pfam03028
    Location:39004582
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:266800
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:13781778
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:31643506
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:35383754
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:19142145
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
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