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kl-5 male fertility factor kl5 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 26067054, updated on 29-Dec-2023

Summary

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Official Symbol
kl-5provided by FlyBase
Official Full Name
male fertility factor kl5provided by FlyBase
Primary source
FLYBASE:FBgn0267433
Locus tag
Dmel_CG45786
See related
AllianceGenome:FB:FBgn0267433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12573; CG17616; CG40444; CG41497; CG45786; Dhc; Dhc-Yh3; DHC4B; DhcYh3; Dmel\CG45786; FBgn0267433; Kl-5; kl5; Lms4
Old locus tag
Dmel_CG40444; Dmel_CG41497
Summary
Predicted to enable ATP binding activity and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement. Part of axonemal dynein complex. Is expressed in adult head; organism; spermatogonium; spermatozoon; and testis. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
h2-h3
Exon count:
17
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) Y NC_024512.1 (22250..137486, complement)

Chromosome Y - NC_024512.1Genomic Context describing neighboring genes Neighboring gene Protein phosphatase 1, Y-linked 1 Neighboring gene polycystine-related-Y Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_024512.1 Chromosome Y Reference Release 6 plus ISO1 MT Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular evolution of a Y chromosome to autosome gene duplication in Drosophila. Dyer KA, et al. Mol Biol Evol, 2011 Mar. PMID 21172827
  2. The advantages of recombination. Carvalho AB. Nat Genet, 2003 Jun. PMID 12776112
  3. The degeneration of Y chromosomes. Charlesworth B, et al. Philos Trans R Soc Lond B Biol Sci, 2000 Nov 29. PMID 11127901, Free PMC Article
  4. Mega-introns in the dynein gene DhDhc7(Y) on the heterochromatic Y chromosome give rise to the giant threads loops in primary spermatocytes of Drosophila hydei. Reugels AM, et al. Genetics, 2000 Feb. PMID 10655227, Free PMC Article
  5. A fertility region on the Y chromosome of Drosophila melanogaster encodes a dynein microtubule motor. Gepner J, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248219, Free PMC Article

See all (90) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables minus-end-directed microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in flagellated sperm motility IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of axonemal dynein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of axonemal dynein complex IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
male fertility factor kl5
Names
CG45786-PC
Y-linked flagellar dynein
dynein heavy chain in Yh3
dynein-related heavy chain
kl-5-PC
male fertility factor kl-5
NP_001015499.4
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_024512.1 Reference assembly

    Range
    22250..137486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001015499.4 → NP_001015499.4  male fertility factor kl5 [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5LJN5, Q9U3Y5
    Conserved Domains (6) summary
    pfam03028
    Location:3864 → 4549
    Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
    pfam08385
    Location:197 → 763
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1368 → 1770
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12777
    Location:3140 → 3480
    MT; Microtubule-binding stalk of dynein motor
    pfam12781
    Location:3509 → 3722
    AAA_9; ATP-binding dynein motor region D5
    cl21455
    Location:2860 → 3127
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5LJN5 Q5LJN5
Q9TW74 Q9TW74
Q9U3Y5 Q9U3Y5
V9GZM3 V9GZM3

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials