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Fatp1 Fatty acid transport protein 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 26067068, updated on 11-Apr-2024

Summary

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Official Symbol
Fatp1provided by FlyBase
Official Full Name
Fatty acid transport protein 1provided by FlyBase
Primary source
FLYBASE:FBgn0267828
Locus tag
Dmel_CG46149
See related
AllianceGenome:FB:FBgn0267828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0121795.74; CG45083; CG46149; CG7400; dFatp; dFATP; Dmel\CG46149; Dromel_CG7400_FBtr0080133_fatp_mORF; Dromel_CG7400_FBtr0080133_fatp_uORF; fatp; Fatp; FATP; l(2)k10307; SLC27A1/4; SLC27A4
Old locus tag
Dmel_CG45083; Dmel_CG7400
Summary
Predicted to enable long-chain fatty acid transporter activity and long-chain fatty acid-CoA ligase activity. Involved in triglyceride homeostasis. Located in endomembrane system. Is expressed in several structures, including embryonic epidermis; embryonic/larval posterior spiracle; gut section; retina; and yolk nucleus. Orthologous to several human genes including SLC27A1 (solute carrier family 27 member 1) and SLC27A4 (solute carrier family 27 member 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
31F4-31F5; 2-43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10510672..10517218, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Myosin 31DF Neighboring gene antisense RNA:CR44224 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Leucine-rich repeat 47 Neighboring gene Lipase 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NT_033779.5 Chromosome 2L Reference Release 6 plus ISO1 MT Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. dFatp regulates nutrient distribution and long-term physiology in Drosophila. Sujkowski A, et al. Aging Cell, 2012 Dec. PMID 22809097, Free PMC Article
  2. Fatty acid transport proteins in disease: New insights from invertebrate models. Dourlen P, et al. Prog Lipid Res, 2015 Oct. PMID 26416577
  3. The Tomato/GFP-FLP/FRT method for live imaging of mosaic adult Drosophila photoreceptor cells. Dourlen P, et al. J Vis Exp, 2013 Sep 20. PMID 24084155, Free PMC Article
  4. Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival. Dourlen P, et al. PLoS Genet, 2012. PMID 22844251, Free PMC Article
  5. The pineapple eye gene is required for survival of Drosophila imaginal disc cells. Shi W, et al. Genetics, 2003 Dec. PMID 14704172, Free PMC Article

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acid-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables very long-chain fatty acid-CoA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in long-chain fatty acid import into cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in long-chain fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
fatty acid transport protein 1
Names
CG46149-PA
CG46149-PB
CG46149-PE
CG46149-PF
Fatp1-PA
Fatp1-PB
Fatp1-PE
Fatp1-PF
fatty acid (long chain) transport protein
fatty acid transport protein
NP_001162940.3
NP_001260354.1
NP_524723.2
NP_723597.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10510672..10517218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164934.2 → NP_723597.1  fatty acid transport protein 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723597.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960E1, Q9VKU1
    Conserved Domains (2) summary
    cd05939
    Location:79 → 592
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
    PRK08279
    Location:33 → 626
    PRK08279; long-chain-acyl-CoA synthetase; Validated

  2. NM_079984.4 → NP_524723.2  fatty acid transport protein 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524723.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960E1, Q9VKU1
    Conserved Domains (2) summary
    cd05939
    Location:79 → 592
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
    PRK08279
    Location:33 → 626
    PRK08279; long-chain-acyl-CoA synthetase; Validated

  3. NM_001169469.3 → NP_001162940.3  fatty acid transport protein 1, isoform F [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHE4
    Conserved Domains (2) summary
    cd05939
    Location:199 → 712
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
    PRK08279
    Location:153 → 746
    PRK08279; long-chain-acyl-CoA synthetase; Validated

  4. NM_001273425.3 → NP_001260354.1  fatty acid transport protein 1, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260354.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q960E1, Q9VKU1
    Conserved Domains (2) summary
    cd05939
    Location:79 → 592
    hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
    PRK08279
    Location:33 → 626
    PRK08279; long-chain-acyl-CoA synthetase; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHE4 E1JHE4
Q9VKU1 Q9VKU1

Gene LinkOut

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