U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mt-Atp6 ATP synthase 6, mitochondrial [ Rattus norvegicus (Norway rat) ]

Gene ID: 26197, updated on 29-Feb-2024

Summary

Go to the top of the page Help
Official Symbol
mt-Atp6provided by RGD
Official Full Name
ATP synthase 6, mitochondrialprovided by RGD
Primary source
RGD:621239
See related
AllianceGenome:RGD:621239
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
ATP6
Summary
Predicted to contribute to proton-transporting ATP synthase activity, rotational mechanism. Involved in aging and response to hyperoxia. Predicted to be integral component of membrane. Predicted to be part of mitochondrial proton-transporting ATP synthase complex. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy; NARP syndrome; Parkinson's disease; multiple sclerosis; and systemic lupus erythematosus. Orthologous to human MT-ATP6 (mitochondrially encoded ATP synthase membrane subunit 6). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mt-Atp6 in Genome Data Viewer
Annotation release Status Assembly Chr Location
RS_2023_06 latest, but not current mRatBN7.2 (GCF_015227675.2) MT (non-nuclear) NC_001665.2 (7919..8599)
106 previous assembly Rnor_6.0 (GCF_000001895.5) MT (non-nuclear) NC_001665.2 (7919..8599)

Chromosome MT - NC_001665.2Genomic Context describing neighboring genes Neighboring gene COXII Neighboring gene tRNA-Lys Neighboring gene ATPase subunit 8 Neighboring gene cytochrome c oxidase subunit 3 Neighboring gene tRNA-Gly

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The mitochondrial genome sequence of a diabetes disease Rattus norvegicus Wistar strain. Tang YX, et al. Mitochondrial DNA A DNA Mapp Seq Anal, 2016 May. PMID 25317643
  2. [Altered expression of mitochondrial DNA encoding ATP 6, 8 and encoding protein in energy metabolism during cold preservation and reperfusion injury in rat liver transplantation]. Zhang Y, et al. Zhonghua Yi Xue Za Zhi, 2010 Mar 16. PMID 20450733
  3. Effects of hyperoxia on mitochondrial multienzyme complex III and V in premature newborn rat lung. Cai C, et al. J Huazhong Univ Sci Technolog Med Sci, 2008 Apr. PMID 18481000
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The abnormal expressions of mtDNA ATPase 6, ATPase 8 genes result in disordered mitochondrial energy metabolism during cold preservation and reperfusion injury in rat liver transplantation.
    Title: [Altered expression of mitochondrial DNA encoding ATP 6, 8 and encoding protein in energy metabolism during cold preservation and reperfusion injury in rat liver transplantation].
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to proton-transporting ATP synthase activity, rotational mechanism ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proton motive force-driven ATP synthesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton motive force-driven mitochondrial ATP synthesis ISO
Inferred from Sequence Orthology
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in response to hyperoxia IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
part_of mitochondrial proton-transporting ATP synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mitochondrial proton-transporting ATP synthase complex ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial proton-transporting ATP synthase complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of proton-transporting ATP synthase complex, coupling factor F(o) IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ATPase subunit 6
Names
ATP synthase F0 subunit 6

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001665.2 Reference assembly

    Range
    7919..8599
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_665634.1 ATP synthase F0 subunit 6 (mitochondrion) [Rattus norvegicus]

    See identical proteins and their annotated locations for YP_665634.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P05504, Q9T2E9
    UniProtKB/TrEMBL
    Q06QE5, Q8HIC7, S5S1E9
    Related
    ENSRNOP00000049769.3
    Conserved Domains (1) summary
    MTH00101
    Location:1 → 226
    ATP6; ATP synthase F0 subunit 6; Validated
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P05504.3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous