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Ing1 inhibitor of growth family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 26356, updated on 23-Jun-2021

Summary

Official Symbol
Ing1provided by MGI
Official Full Name
inhibitor of growth family, member 1provided by MGI
Primary source
MGI:MGI:1349481
See related
Ensembl:ENSMUSG00000045969
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mING; p33I; mING1h; p33Ing1; AA407184; AI875420; p37Ing1b; 2610028J21Rik
Expression
Ubiquitous expression in CNS E11.5 (RPKM 19.0), testis adult (RPKM 15.3) and 28 other tissues See more
Orthologs
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Genomic context

See Ing1 in Genome Data Viewer
Location:
8; 8 A1.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11605762..11613251)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11555762..11563251)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (11556066..11563250)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene NAD(P)HX dehydratase Neighboring gene cysteinyl-tRNA synthetase 2 (mitochondrial)(putative) Neighboring gene ankyrin repeat domain 10 Neighboring gene microRNA 7238 Neighboring gene RIKEN cDNA 1700016D06 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
inhibitor of growth protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302451.1NP_001289380.1  inhibitor of growth protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an upstream alternate 5' terminal exon and uses an alternate in-frame splice site in the 5' coding region which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA407185, AK076482, AK141466, BX528243, CJ086997
    UniProtKB/TrEMBL
    Q3ULE3
    Conserved Domains (2) summary
    cd15584
    Location:176220
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    pfam12998
    Location:175
    ING; Inhibitor of growth proteins N-terminal histone-binding
  2. NM_001302457.1NP_001289386.1  inhibitor of growth protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001289386.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AK076482, AK141466, AK145553, BX528243
    Consensus CDS
    CCDS85499.1
    UniProtKB/Swiss-Prot
    Q9QXV3
    UniProtKB/TrEMBL
    Q3ULE3
    Related
    ENSMUSP00000147476.2, ENSMUST00000210740.2
    Conserved Domains (2) summary
    COG5034
    Location:37163
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15584
    Location:118162
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
  3. NM_001302458.1NP_001289387.1  inhibitor of growth protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001289387.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC124475, AK076482, BX528243, CK624100
    Consensus CDS
    CCDS85499.1
    UniProtKB/Swiss-Prot
    Q9QXV3
    UniProtKB/TrEMBL
    Q3ULE3
    Related
    ENSMUSP00000148030.2, ENSMUST00000211007.2
    Conserved Domains (2) summary
    COG5034
    Location:37163
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15584
    Location:118162
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
  4. NM_001302459.1NP_001289388.1  inhibitor of growth protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001289388.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses a downstream alternate 5' terminal exon, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC124475, AK035490, BX528243, BY063246
    Consensus CDS
    CCDS85499.1
    UniProtKB/Swiss-Prot
    Q9QXV3
    UniProtKB/TrEMBL
    Q3ULE3
    Related
    ENSMUSP00000147892.2, ENSMUST00000209565.2
    Conserved Domains (2) summary
    COG5034
    Location:37163
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15584
    Location:118162
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
  5. NM_001302460.1NP_001289389.1  inhibitor of growth protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001289389.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC124475, AK035490, AK141466, BX528243, CJ086997, DV655694
    Consensus CDS
    CCDS85499.1
    UniProtKB/Swiss-Prot
    Q9QXV3
    UniProtKB/TrEMBL
    Q3ULE3
    Related
    ENSMUSP00000148248.2, ENSMUST00000209646.2
    Conserved Domains (2) summary
    COG5034
    Location:37163
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15584
    Location:118162
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
  6. NM_011919.5NP_036049.2  inhibitor of growth protein 1 isoform 1

    See identical proteins and their annotated locations for NP_036049.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA407185, AC124475, AK076482, BX528243, CA320790
    Consensus CDS
    CCDS22097.1
    UniProtKB/Swiss-Prot
    Q9QXV3
    Related
    ENSMUSP00000062593.5, ENSMUST00000054399.6
    Conserved Domains (2) summary
    cd15584
    Location:212256
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    pfam12998
    Location:15111
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    11605762..11613251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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