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Ing1 inhibitor of growth family, member 1 [ Mus musculus (house mouse) ]

Gene ID: 26356, updated on 5-Mar-2024

Summary

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Official Symbol
Ing1provided by MGI
Official Full Name
inhibitor of growth family, member 1provided by MGI
Primary source
MGI:MGI:1349481
See related
Ensembl:ENSMUSG00000045969 AllianceGenome:MGI:1349481
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mING1h; p33Ing1; p37Ing1b; 2610028J21Rik
Summary
Predicted to enable methylated histone binding activity. Acts upstream of or within positive regulation of transcription, DNA-templated; protein import into nucleus; and regulation of cell death. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hemolymphoid system gland; and liver. Human ortholog(s) of this gene implicated in head and neck squamous cell carcinoma and squamous cell carcinoma. Orthologous to human ING1 (inhibitor of growth family member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 19.0), testis adult (RPKM 15.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 A1.1; 8 5.73 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (11605762..11613251)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (11555762..11563251)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene NAD(P)HX dehydratase Neighboring gene cysteinyl-tRNA synthetase 2, mitochondrial Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:11550723-11550832 Neighboring gene STARR-seq mESC enhancer starr_20716 Neighboring gene STARR-positive B cell enhancer ABC_E9718 Neighboring gene STARR-positive B cell enhancer ABC_E2856 Neighboring gene STARR-positive B cell enhancer ABC_E1101 Neighboring gene ankyrin repeat domain 10 Neighboring gene STARR-seq mESC enhancer starr_20718 Neighboring gene STARR-positive B cell enhancer ABC_E9307 Neighboring gene STARR-seq mESC enhancer starr_20722 Neighboring gene microRNA 7238 Neighboring gene STARR-seq mESC enhancer starr_20723 Neighboring gene sperm acrosome associated 7B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons. Leighton LJ, et al. Neuroscience, 2018 Jan 15. PMID 29158107, Free PMC Article
  2. Inhibitors of Growth 1b Suppresses Peroxisome Proliferator-Activated Receptor-β/δ Expression Through Downregulation of Hypoxia-Inducible Factor 1α in Osteoblast Differentiation. Qu B, et al. DNA Cell Biol, 2016 Apr. PMID 26849833, Free PMC Article
  3. Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1. Menéndez C, et al. Pigment Cell Melanoma Res, 2014 Jul. PMID 24655373
  4. Identification of the p33(ING1)-regulated genes that include cyclin B1 and proto-oncogene DEK by using cDNA microarray in a mouse mammary epithelial cell line NMuMG. Takahashi M, et al. Cancer Res, 2002 Apr 15. PMID 11956069
  5. Structure and regulation of the mouse ing1 gene. Three alternative transcripts encode two phd finger proteins that have opposite effects on p53 function. Zeremski M, et al. J Biol Chem, 1999 Nov 5. PMID 10542254

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ING1 knockdown leads to decreased expression of genes related to synaptic plasticity, including the regulatory subunit of calcineurin, Ppp3r1. In addition, ING1 binding at a site upstream of the transcription start site (TSS) of Ppp3r1 depends on yet another group of neuroepigenetic regulatory proteins, the Piwi-like family, which are also involved in DNA repair.
    Title: A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons.
  2. Taken together, our findings provide evidence for a novel crosstalk and a crossregulation between ING1 and ING2 in regulating androgen receptor-mediated transactivation and suggest that ING2 acts as a novel corepressor that inhibits AR signaling, prostate cancer cell growth, and migration.
    Title: A novel crosstalk between the tumor suppressors ING1 and ING2 regulates androgen receptor signaling.
  3. ING1b is an important regulator of osteoblast differentiation and suppresses PPAR-beta/delta.
    Title: Inhibitors of Growth 1b Suppresses Peroxisome Proliferator-Activated Receptor-β/δ Expression Through Downregulation of Hypoxia-Inducible Factor 1α in Osteoblast Differentiation.
  4. Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1.
    Title: Increased melanoma formation and dissemination in TyrNRas mice deficient in the tumor suppressor Ing1.
  5. Study reveals a novel connection between ING1 and a regulator of microRNA biogenesis and identifies new links between tumor suppressor proteins and the microRNA machinery.
    Title: Regulation of the microRNA processor DGCR8 by the tumor suppressor ING1.
  6. Analysis of marker gene expression in p37(Ing1b)/p53 null tumors indicates that the double-null mice develop both nongerminal center and germinal center B-cell-like DLBL.
    Title: p37Ing1b regulates B-cell proliferation and cooperates with p53 to suppress diffuse large B-cell lymphomagenesis.
  7. A more sophisticated approach, using neural networks, permits prediction of interaction among three or more genes (p53, bax, and ING1).
    Title: Nonlinear cooperation of p53-ING1-induced bax expression and protein S-nitrosylation in GSNO-induced thymocyte apoptosis: a quantitative approach with cross-platform validation.
  8. important role for the Ing1 locus in protection against oncogenic stress in vivo, both as a mediator of p53 activation and as a regulator of chromatin remodeling processes.
    Title: Ing1 mediates p53 accumulation and chromatin modification in response to oncogenic stress.
  9. p37(Ing1) can negatively regulate cell growth and apoptosis in a p53-independent manner.
    Title: Deletion of p37Ing1 in mice reveals a p53-independent role for Ing1 in the suppression of cell proliferation, apoptosis, and tumorigenesis.
  10. p33ING1 expression induces features of cellular senescence through two silencing domains and interaction with Ras
    Title: Growth inhibition by the tumor suppressor p33ING1 in immortalized and primary cells: involvement of two silencing domains and effect of Ras.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of programmed cell death IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
inhibitor of growth protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001302451.1 → NP_001289380.1  inhibitor of growth protein 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an upstream alternate 5' terminal exon and uses an alternate in-frame splice site in the 5' coding region which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 2, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AA407185, AK076482, AK141466, BX528243, CJ086997
    UniProtKB/TrEMBL
    Q3ULE3
    Conserved Domains (2) summary
    cd15584
    Location:176 → 220
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    pfam12998
    Location:1 → 75
    ING; Inhibitor of growth proteins N-terminal histone-binding

  2. NM_001302457.1 → NP_001289386.1  inhibitor of growth protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001289386.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AK076482, AK141466, AK145553, BX528243
    Consensus CDS
    CCDS85499.1
    UniProtKB/TrEMBL
    A0A1B0GT89, Q3ULE3
    Related
    ENSMUSP00000147476.2, ENSMUST00000210740.2
    Conserved Domains (2) summary
    COG5034
    Location:37 → 163
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15584
    Location:118 → 162
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)

  3. NM_001302458.1 → NP_001289387.1  inhibitor of growth protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001289387.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC124475, AK076482, BX528243, CK624100
    Consensus CDS
    CCDS85499.1
    UniProtKB/TrEMBL
    A0A1B0GT89, Q3ULE3
    Related
    ENSMUSP00000148030.2, ENSMUST00000211007.2
    Conserved Domains (2) summary
    COG5034
    Location:37 → 163
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15584
    Location:118 → 162
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)

  4. NM_001302459.1 → NP_001289388.1  inhibitor of growth protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001289388.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses a downstream alternate 5' terminal exon, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC124475, AK035490, BX528243, BY063246
    Consensus CDS
    CCDS85499.1
    UniProtKB/TrEMBL
    A0A1B0GT89, Q3ULE3
    Related
    ENSMUSP00000147892.2, ENSMUST00000209565.2
    Conserved Domains (2) summary
    COG5034
    Location:37 → 163
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15584
    Location:118 → 162
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)

  5. NM_001302460.1 → NP_001289389.1  inhibitor of growth protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001289389.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an upstream alternate 5' terminal exon and lacks an exon in the 5' region, which results in the use of a downstream start codon, compared to variant 1. It encodes isoform 3, which has a shorter N-terminus, compared to isoform 1. Variant 3, 4, 5 and 6 encode the same protein.
    Source sequence(s)
    AC124475, AK035490, AK141466, BX528243, CJ086997, DV655694
    Consensus CDS
    CCDS85499.1
    UniProtKB/TrEMBL
    A0A1B0GT89, Q3ULE3
    Related
    ENSMUSP00000148248.2, ENSMUST00000209646.2
    Conserved Domains (2) summary
    COG5034
    Location:37 → 163
    TNG2; Chromatin remodeling protein, contains PhD zinc finger [Chromatin structure and dynamics]
    cd15584
    Location:118 → 162
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)

  6. NM_011919.5 → NP_036049.2  inhibitor of growth protein 1 isoform 1

    See identical proteins and their annotated locations for NP_036049.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA407185, AC124475, AK076482, BX528243, CA320790
    Consensus CDS
    CCDS22097.1
    UniProtKB/Swiss-Prot
    B2RWH0, Q9QUP8, Q9QXV3, Q9QXV4, Q9QZX3
    Related
    ENSMUSP00000062593.5, ENSMUST00000054399.6
    Conserved Domains (2) summary
    cd15584
    Location:212 → 256
    PHD_ING1_2; PHD finger found in inhibitor of growth protein 1 (ING1) and 2 (ING2)
    pfam12998
    Location:15 → 111
    ING; Inhibitor of growth proteins N-terminal histone-binding

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    11605762..11613251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QXV3.1 GenPept UniProtKB/Swiss-Prot:Q9QXV3

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