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Ceacam2 carcinoembryonic antigen-related cell adhesion molecule 2 [ Mus musculus (house mouse) ]

Gene ID: 26367, updated on 23-Jun-2021

Summary

Official Symbol
Ceacam2provided by MGI
Official Full Name
carcinoembryonic antigen-related cell adhesion molecule 2provided by MGI
Primary source
MGI:MGI:1347246
See related
Ensembl:ENSMUSG00000054385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bgp; Bgp2; AI267129; Ceacam2-L
Expression
Biased expression in colon adult (RPKM 196.9), large intestine adult (RPKM 143.6) and 4 other tissues See more
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Genomic context

See Ceacam2 in Genome Data Viewer
Location:
7 A3; 7 13.87 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25215467..25239429, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25516042..25540004, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (26301061..26325023, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4732471J01 gene Neighboring gene carcinoembryonic antigen-related cell adhesion molecule 1 Neighboring gene predicted gene, 38967 Neighboring gene predicted gene, 29918 Neighboring gene predicted gene, 38569

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GPI anchor binding ISO
Inferred from Sequence Orthology
more info
 
enables actin binding ISO
Inferred from Sequence Orthology
more info
 
enables bile acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
 
enables calmodulin binding ISO
Inferred from Sequence Orthology
more info
 
enables filamin binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein dimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in bile acid and bile salt transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cell-cell adhesion via plasma-membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within homophilic cell adhesion via plasma membrane adhesion molecules IDA
Inferred from Direct Assay
more info
PubMed 
involved_in insulin catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in insulin receptor internalization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of brown fat cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fatty acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hepatocyte proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of homophilic cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of homophilic cell adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of phosphatidylinositol 3-kinase signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of T cell receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
 
located_in anchored component of membrane ISO
Inferred from Sequence Orthology
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basal plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in lateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
carcinoembryonic antigen-related cell adhesion molecule 2
Names
BGP-2
CEA-related cell adhesion molecule 2
biliary glycoprotein 2
carcinoembryonic antigen-related cell adhesion molecule 2- Long

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113368.1NP_001106839.1  carcinoembryonic antigen-related cell adhesion molecule 2 isoform a precursor

    See identical proteins and their annotated locations for NP_001106839.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC162443
    Consensus CDS
    CCDS52153.1
    UniProtKB/Swiss-Prot
    Q925P2
    Related
    ENSMUSP00000048118.9, ENSMUST00000044547.10
    Conserved Domains (4) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:246320
    IG_like; Immunoglobulin like
    pfam13895
    Location:242320
    Ig_2; Immunoglobulin domain
    cl11960
    Location:146235
    Ig; Immunoglobulin domain
  2. NM_001113369.1NP_001106840.1  carcinoembryonic antigen-related cell adhesion molecule 2 isoform b precursor

    See identical proteins and their annotated locations for NP_001106840.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks alternate in-frame exons, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AC162443
    Consensus CDS
    CCDS52152.1
    UniProtKB/Swiss-Prot
    Q925P2
    Related
    ENSMUSP00000064255.8, ENSMUST00000066503.14
    Conserved Domains (3) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:153232
    IG_like; Immunoglobulin like
    cl11960
    Location:142232
    Ig; Immunoglobulin domain
  3. NM_007543.4NP_031569.1  carcinoembryonic antigen-related cell adhesion molecule 2 isoform c precursor

    See identical proteins and their annotated locations for NP_031569.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the coding region, compared to variant 1, one of which results in a translational frameshift and early stop codon. The resulting protein (isoform c) is shorter than isoform a.
    Source sequence(s)
    AC162443
    Consensus CDS
    CCDS20986.1
    UniProtKB/Swiss-Prot
    Q925P2
    Related
    ENSMUSP00000068540.7, ENSMUST00000064862.13
    Conserved Domains (3) summary
    cd05774
    Location:36140
    Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
    smart00410
    Location:153232
    IG_like; Immunoglobulin like
    cl11960
    Location:142232
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25215467..25239429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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