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Grk6 G protein-coupled receptor kinase 6 [ Mus musculus (house mouse) ]

Gene ID: 26385, updated on 23-Jun-2021

Summary

Official Symbol
Grk6provided by MGI
Official Full Name
G protein-coupled receptor kinase 6provided by MGI
Primary source
MGI:MGI:1347078
See related
Ensembl:ENSMUSG00000074886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gpr; Gprk6
Expression
Ubiquitous expression in spleen adult (RPKM 77.5), thymus adult (RPKM 59.5) and 27 other tissues See more
Orthologs
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Genomic context

See Grk6 in Genome Data Viewer
Location:
13 B1; 13 30.06 cM
Exon count:
19
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (55592865..55608740)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (55445072..55460927)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 13 NC_000079.5 (55546695..55562288)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 34 (sodium phosphate), member 1 Neighboring gene profilin 3 Neighboring gene coagulation factor XII (Hageman factor) Neighboring gene microRNA 6943 Neighboring gene proline rich 7 (synaptic) Neighboring gene drebrin 1 Neighboring gene microRNA 6944

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables G protein-coupled receptor kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables beta-adrenergic receptor kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in desensitization of G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of anion channel activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
G protein-coupled receptor kinase 6
Names
g protein-coupled receptor kinase GRK6
NP_001033107.1
NP_001106182.1
NP_001272992.1
NP_001272993.1
NP_001272994.1
NP_001272995.1
NP_001364005.1
NP_001364006.1
NP_036068.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038018.5NP_001033107.1  G protein-coupled receptor kinase 6 isoform a

    See identical proteins and their annotated locations for NP_001033107.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AK051405, AW048460, CT009762, Y15799
    UniProtKB/Swiss-Prot
    O70293
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  2. NM_001112711.2NP_001106182.1  G protein-coupled receptor kinase 6 isoform c

    See identical proteins and their annotated locations for NP_001106182.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK051405, AW048460, CT009762, Y15799
    Consensus CDS
    CCDS88457.1
    UniProtKB/Swiss-Prot
    O70293
    Related
    ENSMUSP00000152968.2, ENSMUST00000224118.2
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  3. NM_001286063.2NP_001272992.1  G protein-coupled receptor kinase 6 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AK051405, AW048460, CT009762, Y15799
    UniProtKB/Swiss-Prot
    O70293
    UniProtKB/TrEMBL
    A0A286YDZ5
    Related
    ENSMUSP00000153623.2, ENSMUST00000224653.2
    Conserved Domains (3) summary
    smart00220
    Location:154416
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:153437
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:3147
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  4. NM_001286064.2NP_001272993.1  G protein-coupled receptor kinase 6 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (e) is shorter, compared to isoform a.
    Source sequence(s)
    AK051405, AW048460, CT009762, Y15799
    UniProtKB/Swiss-Prot
    O70293
    UniProtKB/TrEMBL
    A0A286YDA5
    Conserved Domains (3) summary
    smart00220
    Location:186443
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185464
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  5. NM_001286065.1NP_001272994.1  G protein-coupled receptor kinase 6 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate in-frame splice site in the central coding region, and uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (f) is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AK051405, AW048460, CT009762, Y15799
    Consensus CDS
    CCDS88458.1
    UniProtKB/Swiss-Prot
    O70293
    UniProtKB/TrEMBL
    A0A286YE10
    Related
    ENSMUSP00000153668.2, ENSMUST00000225925.2
    Conserved Domains (3) summary
    smart00220
    Location:186414
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily
    cl21453
    Location:185435
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001286066.2NP_001272995.1  G protein-coupled receptor kinase 6 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR, 3' UTR, and 3' coding region, and cause translation initiation from a downstream start codon. The encoded isoform (g) has a shorter N-terminus and a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    CT009762
    UniProtKB/TrEMBL
    Q9EP84
    Conserved Domains (2) summary
    smart00220
    Location:1183
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:1204
    PKc_like; Protein Kinases, catalytic domain
  7. NM_001377076.1NP_001364005.1  G protein-coupled receptor kinase 6 isoform h

    Status: VALIDATED

    Source sequence(s)
    CT009762
    Conserved Domains (2) summary
    cd05630
    Location:180464
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:30174
    RGS; Regulator of G protein signaling (RGS) domain superfamily
  8. NM_001377077.1NP_001364006.1  G protein-coupled receptor kinase 6 isoform i

    Status: VALIDATED

    Source sequence(s)
    CT009762
    Conserved Domains (1) summary
    cl21453
    Location:1204
    PKc_like; Protein Kinases, catalytic domain
  9. NM_011938.5NP_036068.2  G protein-coupled receptor kinase 6 isoform b

    See identical proteins and their annotated locations for NP_036068.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a shorter and distinct C-terminus, compared to isoform a.
    Source sequence(s)
    CT009762
    Consensus CDS
    CCDS36676.1
    UniProtKB/Swiss-Prot
    O70293
    UniProtKB/TrEMBL
    Q9EP84
    Related
    ENSMUSP00000097081.4, ENSMUST00000099482.5
    Conserved Domains (3) summary
    smart00220
    Location:186448
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05630
    Location:185469
    STKc_GRK6; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6
    cl02565
    Location:35179
    RGS; Regulator of G protein signaling (RGS) domain superfamily

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    55592865..55608740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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