Format

Send to:

Choose Destination

Hsf4 heat shock transcription factor 4 [ Mus musculus (house mouse) ]

Gene ID: 26386, updated on 23-Jun-2021

Summary

Official Symbol
Hsf4provided by MGI
Official Full Name
heat shock transcription factor 4provided by MGI
Primary source
MGI:MGI:1347058
See related
Ensembl:ENSMUSG00000033249
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ld; HSF 4; HSTF4; ldis1; mHSF4; HSTF 4
Expression
Broad expression in lung adult (RPKM 9.1), cortex adult (RPKM 6.1) and 18 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hsf4 in Genome Data Viewer
Location:
8; 8 D3
Exon count:
13
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (105996392..106002477)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (105269414..105275845)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (107793774..107799745)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene TNFRSF1A-associated via death domain Neighboring gene F-box and leucine-rich repeat protein 8 Neighboring gene RIKEN cDNA 4931428F04 gene Neighboring gene nucleolar protein 3 (apoptosis repressor with CARD domain) Neighboring gene uncharacterized LOC102636360 Neighboring gene exocyst complex component 3-like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within camera-type eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within histone H3-K9 demethylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual perception IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
heat shock factor protein 4
Names
DNA binding protein
binds heat shock DNA elements
heat shock factor 4

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256042.1NP_001242971.1  heat shock factor protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001242971.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC124584
    Consensus CDS
    CCDS57639.1
    UniProtKB/Swiss-Prot
    Q9R0L1
    UniProtKB/TrEMBL
    B2RQY2
    Related
    ENSMUSP00000048904.3, ENSMUST00000036127.9
    Conserved Domains (2) summary
    smart00415
    Location:16120
    HSF; heat shock factor
    pfam15035
    Location:110175
    Rootletin; Ciliary rootlet component, centrosome cohesion
  2. NM_001256044.1NP_001242973.1  heat shock factor protein 4 isoform 3

    See identical proteins and their annotated locations for NP_001242973.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124584, AK148056
    Consensus CDS
    CCDS57640.1
    UniProtKB/TrEMBL
    Q3UG93
    Related
    ENSMUSP00000126278.3, ENSMUST00000163734.9
    Conserved Domains (2) summary
    pfam15035
    Location:50115
    Rootletin; Ciliary rootlet component, centrosome cohesion
    cl12113
    Location:1860
    HSF_DNA-bind; HSF-type DNA-binding
  3. NM_011939.3NP_036069.1  heat shock factor protein 4 isoform 2

    See identical proteins and their annotated locations for NP_036069.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate in-frame splice sites in that result in a frameshift in the central coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct internal segment, compared to isoform 1.
    Source sequence(s)
    AC124584
    Consensus CDS
    CCDS57638.1
    UniProtKB/Swiss-Prot
    Q9R0L1
    Related
    ENSMUSP00000134213.2, ENSMUST00000173859.2
    Conserved Domains (2) summary
    smart00415
    Location:16120
    HSF; heat shock factor
    pfam15035
    Location:110175
    Rootletin; Ciliary rootlet component, centrosome cohesion

RNA

  1. NR_045689.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC124584
    Related
    ENSMUST00000173640.8

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    105996392..106002477
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531041.4XP_006531104.1  heat shock factor protein 4 isoform X4

  2. XM_017312837.3XP_017168326.1  heat shock factor protein 4 isoform X1

    Conserved Domains (1) summary
    smart00415
    Location:16120
    HSF; heat shock factor
  3. XM_006531038.5XP_006531101.1  heat shock factor protein 4 isoform X2

    Conserved Domains (1) summary
    smart00415
    Location:16120
    HSF; heat shock factor
  4. XM_006531039.3XP_006531102.1  heat shock factor protein 4 isoform X3

    Conserved Domains (2) summary
    smart00415
    Location:153
    HSF; heat shock factor
    pfam06546
    Location:192417
    Vert_HS_TF; Vertebrate heat shock transcription factor
Support Center