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Map3k5 mitogen-activated protein kinase kinase kinase 5 [ Mus musculus (house mouse) ]

Gene ID: 26408, updated on 25-Jan-2022

Summary

Official Symbol
Map3k5provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 5provided by MGI
Primary source
MGI:MGI:1346876
See related
Ensembl:ENSMUSG00000071369 AllianceGenome:MGI:1346876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ASK; ASK1; Mekk5; MAPKKK5; 7420452D20Rik
Summary
Enables MAP kinase kinase kinase activity and protein kinase binding activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; positive regulation of JNK cascade; and positive regulation of cell death. Acts upstream of or within several processes, including cellular response to reactive nitrogen species; intracellular signal transduction; and positive regulation of MAPK cascade. Predicted to be located in cytoplasm. Predicted to be part of IRE1-TRAF2-ASK1 complex and protein kinase complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Huntington's disease. Orthologous to human MAP3K5 (mitogen-activated protein kinase kinase kinase 5). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in bladder adult (RPKM 5.2), cortex adult (RPKM 2.8) and 28 other tissues See more
Orthologs
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Genomic context

See Map3k5 in Genome Data Viewer
Location:
10; 10 A3
Exon count:
31
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (19809847..20018496)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (19934101..20142750)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (19654332..19862556)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 35, member D3 Neighboring gene peroxisomal biogenesis factor 7 Neighboring gene RIKEN cDNA 4930405J17 gene Neighboring gene microtubule-associated protein 7 Neighboring gene predicted gene, 51795

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC141518, MGC141519

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables JUN kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to reactive nitrogen species IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within p38MAPK cascade IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of myoblast differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron death ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within programmed necrotic cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell death IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of IRE1-TRAF2-ASK1 complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
part_of protein kinase complex ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 5
Names
ASK-1
MAPK/ERK kinase kinase 5
MEK kinase 5
MEKK 5
apoptosis signal-regulating kinase 1
NP_032606.4
XP_006512802.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008580.4NP_032606.4  mitogen-activated protein kinase kinase kinase 5

    See identical proteins and their annotated locations for NP_032606.4

    Status: VALIDATED

    Source sequence(s)
    AC158620, AC158621, AC171277, AK078668, BC133697
    Consensus CDS
    CCDS35857.1
    UniProtKB/Swiss-Prot
    O35099
    Related
    ENSMUSP00000093485.4, ENSMUST00000095806.10
    Conserved Domains (3) summary
    smart00220
    Location:692945
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06624
    Location:678945
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:172551
    DUF4071; Domain of unknown function (DUF4071)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    19809847..20018496
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512739.5XP_006512802.1  mitogen-activated protein kinase kinase kinase 5 isoform X1

    Conserved Domains (2) summary
    cd06624
    Location:678945
    STKc_ASK; Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase
    pfam13281
    Location:172552
    DUF4071; Domain of unknown function (DUF4071)
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