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Mapk1 mitogen-activated protein kinase 1 [ Mus musculus (house mouse) ]

Gene ID: 26413, updated on 11-Jan-2022

Summary

Official Symbol
Mapk1provided by MGI
Official Full Name
mitogen-activated protein kinase 1provided by MGI
Primary source
MGI:MGI:1346858
See related
Ensembl:ENSMUSG00000063358
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERK; Erk2; MAPK2; PRKM2; Prkm1; C78273; p41mapk; p42mapk; AA407128; AU018647; 9030612K14Rik
Summary
Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein kinase activity. Involved in peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; and response to nicotine. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and cellular response to cytokine stimulus. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in Noonan syndrome 13; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 69.7), cortex adult (RPKM 53.9) and 28 other tissues See more
Orthologs
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Genomic context

See Mapk1 in Genome Data Viewer
Location:
16 A3; 16 10.53 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (16801246..16865317)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (16983382..17047453)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (16983475..17047546)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene 28S ribosomal protein S21, mitochondrial pseudogene Neighboring gene predicted gene 6438 Neighboring gene yippee like 1 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 2 Neighboring gene RIKEN cDNA 2610318N02 gene Neighboring gene microRNA 130b

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables MAP kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables MAP kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA polymerase II CTD heptapeptide repeat kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphotyrosine residue binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Bergmann glial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ERBB signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in aging ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cardiac neural crest cell development involved in heart development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in caveolin-mediated endocytosis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to amino acid starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cadmium ion ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to dopamine ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to reactive oxygen species ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to tumor necrosis factor IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cytosine metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in decidualization ISO
Inferred from Sequence Orthology
more info
 
involved_in diadenosine tetraphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within face development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within face development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heart development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within labyrinthine layer blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipopolysaccharide-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within long-term synaptic potentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lung morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural crest cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within outer ear morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-serine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in peptidyl-threonine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of macrophage chemotaxis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of macrophage proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomerase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of Golgi inheritance TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of cellular pH IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of early endosome to late endosome transport TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within regulation of ossification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of stress-activated MAPK cascade TAS
Traceable Author Statement
more info
PubMed 
involved_in response to epidermal growth factor ISO
Inferred from Sequence Orthology
more info
 
involved_in response to estrogen ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to exogenous dsRNA IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to nicotine IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to nicotine ISO
Inferred from Sequence Orthology
more info
 
involved_in response to toxic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in sensory perception of pain ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within thyroid gland development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within trachea formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus TAS
Traceable Author Statement
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in caveola ISO
Inferred from Sequence Orthology
more info
 
located_in caveola TAS
Traceable Author Statement
more info
PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
PubMed 
located_in dendrite cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in early endosome TAS
Traceable Author Statement
more info
PubMed 
located_in focal adhesion TAS
Traceable Author Statement
more info
PubMed 
located_in late endosome TAS
Traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion TAS
Traceable Author Statement
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in pseudopodium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase 1
Names
ERK-2
ERT1
MAP kinase 1
MAP kinase 2
MAPK 1
MAPK 2
extracellular signal-regulated kinase 2
mitogen-activated protein kinase 2
p42-MAPK
NP_001033752.1
NP_001344044.1
NP_036079.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001038663.1NP_001033752.1  mitogen-activated protein kinase 1

    See identical proteins and their annotated locations for NP_001033752.1

    Status: VALIDATED

    Source sequence(s)
    BB648734, D10939
    Consensus CDS
    CCDS27992.1
    UniProtKB/Swiss-Prot
    P63085
    Related
    ENSMUSP00000111396.2, ENSMUST00000115731.10
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
  2. NM_001357115.1NP_001344044.1  mitogen-activated protein kinase 1

    Status: VALIDATED

    Source sequence(s)
    AC166346, AC166832
    Consensus CDS
    CCDS27992.1
    Related
    ENSMUSP00000156154.2, ENSMUST00000232611.2
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases
  3. NM_011949.3NP_036079.1  mitogen-activated protein kinase 1

    See identical proteins and their annotated locations for NP_036079.1

    Status: VALIDATED

    Source sequence(s)
    AC154667, AK132241, BB648734
    Consensus CDS
    CCDS27992.1
    UniProtKB/Swiss-Prot
    P63085
    Related
    ENSMUSP00000065983.8, ENSMUST00000069107.14
    Conserved Domains (1) summary
    cd07849
    Location:17351
    STKc_ERK1_2_like; Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    16801246..16865317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_028991.1: Suppressed sequence

    Description
    NM_028991.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
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