Mapk9 mitogen-activated protein kinase 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mapk9provided by MGI
Official Full Name: mitogen-activated protein kinase 9provided by MGI
Primary source: MGI:MGI:1346862
See related: Ensembl:ENSMUSG00000020366 AllianceGenome:MGI:1346862
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: JNK2; Prkm9; p54aSAPK
Summary: Enables protein serine/threonine/tyrosine kinase activity. Involved in peptidyl-serine phosphorylation; positive regulation of cellular protein metabolic process; and regulation of circadian rhythm. Acts upstream of or within several processes, including positive regulation of apoptotic signaling pathway; positive regulation of podosome assembly; and protein localization to tricellular tight junction. Located in cytosol and mitochondrion. Is expressed in several structures, including brain; extraembryonic component; future brain; genitourinary system; and spinal cord. Human ortholog(s) of this gene implicated in colorectal cancer; pancreatic adenocarcinoma; and type 2 diabetes mellitus. Orthologous to human MAPK9 (mitogen-activated protein kinase 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cerebellum adult (RPKM 32.4), cortex adult (RPKM 26.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B1.2; 11 29.96 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (49737558..49777248)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (49846728..49886421)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury.
Title: miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury.
Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice.
Title: Protein Kinase N Family Negatively Regulates Constitutive Androstane Receptor-Mediated Transcriptional Induction of Cytochrome P450 2b10 in the Livers of Mice.
JNK2, a Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca(2+)]SR Leak-Load Relationship.
Title: JNK2, a Newly-Identified SERCA2 Enhancer, Augments an Arrhythmic [Ca(2+)](SR) Leak-Load Relationship.
Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway.
Title: Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway.
Regulatory role of the TLR4/JNK signaling pathway in sepsisinduced myocardial dysfunction.
Title: Regulatory role of the TLR4/JNK signaling pathway in sepsis‑induced myocardial dysfunction.
Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKbeta-Deficient Osteoblasts.
Title: Both JNK1 and JNK2 Are Indispensable for Sensitized Extracellular Matrix Mineralization in IKKβ-Deficient Osteoblasts.
Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice.
Title: Deletion of JNK Enhances Senescence in Joint Tissues and Increases the Severity of Age-Related Osteoarthritis in Mice.
Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice.
Title: Activation of JNK signaling promotes all-trans-retinal-induced photoreceptor apoptosis in mice.
The IL-33-induced p38-/JNK1/2-TNFalpha axis is antagonized by activation of beta-adrenergic-receptors in dendritic cells.
Title: The IL-33-induced p38-/JNK1/2-TNFα axis is antagonized by activation of β-adrenergic-receptors in dendritic cells.
Increased expression of desmin and vimentin reduces bladder smooth muscle contractility via JNK2.
Title: Increased expression of desmin and vimentin reduces bladder smooth muscle contractility via JNK2.

Submit: New GeneRIF Correction See all GeneRIFs (134)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (4) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI851083 (e-PCR)
- UniSTS:185879

Mapk9 (e-PCR), detects polymorphism
- UniSTS:532282

D11Sac3 (e-PCR)
- UniSTS:13444

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables JUN kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables JUN kinase activity	ISO Inferred from Sequence Orthology more info
enables JUN kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables MAP kinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activator activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine/tyrosine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in JNK cascade	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cellular response to UV	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cadmium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to reactive oxygen species	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response to wounding	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chemokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production involved in inflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of macrophage derived foam cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric-oxide synthase biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of podosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to tricellular tight junction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in release of cytochrome c from mitochondria	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to cadmium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within rhythmic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Schaffer collateral - CA1 synapse	IC Inferred by Curator more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
located_in perikaryon	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: mitogen-activated protein kinase 9

Names: JNK/SAPK alpha; Jun kinase; MAP kinase 9; MAPK 9; c-Jun N-terminal kinase 2; protein kinase, mitogen-activated 9; stress-activated protein kinase JNK2

NP_001157143.1

EC 2.7.11.24

NP_001157144.1

EC 2.7.11.24

NP_058657.1

EC 2.7.11.24

NP_997575.2

EC 2.7.11.24

XP_017170051.1

EC 2.7.11.24

XP_017170052.1

EC 2.7.11.24

XP_030101882.1

EC 2.7.11.24

XP_030101883.1

EC 2.7.11.24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163671.1 → NP_001157143.1 mitogen-activated protein kinase 9 isoform beta2

See identical proteins and their annotated locations for NP_001157143.1

Status: VALIDATED

Description

Transcript Variant: This variant (beta2) contains an alternate in-frame coding exon of the same length compared to variant alpha2. This results in an isoform (beta2) of the same length, but with a different internal protein segment compared to isoform alpha2.

Source sequence(s)

AK031959, AK031974, BB362351, CX235052

Consensus CDS

CCDS48782.1

UniProtKB/Swiss-Prot

Q5NCK9, Q5NCL5, Q8C097, Q8VDD2, Q9WTU4, Q9WTU5, Q9WTU6

Related

ENSMUSP00000136977.2, ENSMUST00000178543.8

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_001163672.1 → NP_001157144.1 mitogen-activated protein kinase 9 isoform alpha1

See identical proteins and their annotated locations for NP_001157144.1

Status: VALIDATED

Description

Transcript Variant: This variant (alpha1) uses an alternate acceptor splice site at the 3' terminal exon compared to variant alpha2. This causes a frameshift and early translation termination, resulting in a shorter isoform (alpha1) with a distinct C-terminus compared to isoform alpha2.

Source sequence(s)

AK031959, AK031974, BB362351, CX235052

Consensus CDS

CCDS48783.1

UniProtKB/TrEMBL

Q8C094

Related

ENSMUSP00000132864.2, ENSMUST00000164643.8

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_016961.3 → NP_058657.1 mitogen-activated protein kinase 9 isoform beta1

See identical proteins and their annotated locations for NP_058657.1

Status: VALIDATED

Description

Transcript Variant: This variant (beta1) contains an alternate in-frame coding exon, and uses an alternate acceptor splice site at the 3' terminal exon compared to variant alpha2. This results in a shorter isoform (beta1) with a different internal protein segment, and with a distinct C-terminus compared to isoform alpha2.

Source sequence(s)

AK031959, AK031974, BB362351, CX235052

Consensus CDS

CCDS24624.1

UniProtKB/TrEMBL

Q8C094

Related

ENSMUSP00000104808.3, ENSMUST00000109179.9

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
NM_207692.2 → NP_997575.2 mitogen-activated protein kinase 9 isoform alpha2

See identical proteins and their annotated locations for NP_997575.2

Status: VALIDATED

Description

Transcript Variant: This variant (alpha2) encodes isoform alpha2.

Source sequence(s)

AK031959, AK031974, BB362351, CX235052

Consensus CDS

CCDS24623.1

UniProtKB/TrEMBL

Q5NCK8

Related

ENSMUSP00000020634.8, ENSMUST00000020634.14

Conserved Domains (1) summary

cd07850
Location:25 → 360

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

49737558..49777248

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246023.2 → XP_030101883.1 mitogen-activated protein kinase 9 isoform X4

UniProtKB/TrEMBL

Q8C094

Conserved Domains (1) summary

cd07850
Location:16 → 334

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
XM_017314563.3 → XP_017170052.1 mitogen-activated protein kinase 9 isoform X2

UniProtKB/TrEMBL

Q8C094

Conserved Domains (1) summary

cd07850
Location:16 → 334

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
XM_017314562.3 → XP_017170051.1 mitogen-activated protein kinase 9 isoform X1

UniProtKB/TrEMBL

Q8C094

Conserved Domains (1) summary

cd07850
Location:16 → 334

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
XM_030246022.2 → XP_030101882.1 mitogen-activated protein kinase 9 isoform X3

UniProtKB/TrEMBL

Q8C094

Conserved Domains (1) summary

cd07850
Location:16 → 334

STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase