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Psmb2 proteasome (prosome, macropain) subunit, beta type 2 [ Mus musculus (house mouse) ]

Gene ID: 26445, updated on 23-Jun-2021

Summary

Official Symbol
Psmb2provided by MGI
Official Full Name
proteasome (prosome, macropain) subunit, beta type 2provided by MGI
Primary source
MGI:MGI:1347045
See related
Ensembl:ENSMUSG00000028837
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C7-I; HC7-; HC7-I; D4Wsu33; AU045357; AW108089; D4Wsu33e
Expression
Ubiquitous expression in large intestine adult (RPKM 90.9), placenta adult (RPKM 89.8) and 28 other tissues See more
Orthologs
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Genomic context

See Psmb2 in Genome Data Viewer
Location:
4 D2.2; 4 60.9 cM
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (126571421..126603508)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126677637..126709715)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (126354887..126386959)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 46870 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene transcription factor AP-2, epsilon Neighboring gene expressed sequence AU040320 Neighboring gene neurochondrin

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proteasomal protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis involved in cellular protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome complex ISO
Inferred from Sequence Orthology
more info
 
part_of proteasome core complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
proteasome subunit beta type-2
Names
macropain subunit C7-I
multicatalytic endopeptidase complex subunit C7-I
proteasome component C7-I
NP_036100.3
XP_006503180.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011970.4NP_036100.3  proteasome subunit beta type-2

    See identical proteins and their annotated locations for NP_036100.3

    Status: VALIDATED

    Source sequence(s)
    BB853639, BQ043213, CB321399
    Consensus CDS
    CCDS18657.1
    UniProtKB/Swiss-Prot
    Q9R1P3
    Related
    ENSMUSP00000030642.3, ENSMUST00000030642.3
    Conserved Domains (1) summary
    cd03758
    Location:1192
    proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    126571421..126603508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503117.5XP_006503180.1  proteasome subunit beta type-2 isoform X1

    Conserved Domains (1) summary
    cd03758
    Location:1151
    proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
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