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Sema4g sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G [ Mus musculus (house mouse) ]

Gene ID: 26456, updated on 21-Apr-2024

Summary

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Official Symbol
Sema4gprovided by MGI
Official Full Name
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Gprovided by MGI
Primary source
MGI:MGI:1347047
See related
Ensembl:ENSMUSG00000025207 AllianceGenome:MGI:1347047
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including generation of neurons; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to act upstream of or within cell differentiation and nervous system development. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. Is expressed in several structures, including gut; liver; nervous system; sensory organ; and urinary system. Orthologous to human SEMA4G (semaphorin 4G). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 249.8), liver adult (RPKM 161.1) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 C3; 19 38.16 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44976838..44991836)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44988743..45003397)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene SMC5-SMC6 complex localization factor 2 Neighboring gene predicted gene, 25482 Neighboring gene RIKEN cDNA 4930414N06 gene Neighboring gene STARR-positive B cell enhancer ABC_E9998 Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper, putative tumor suppressor 2 Neighboring gene PDZ domain containing 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization and expression of sema4g, a novel member of the semaphorin gene family. Li H, et al. Mech Dev, 1999 Sep. PMID 10495281
  2. Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair. Xia J, et al. Dev Cell, 2015 May 4. PMID 25892012
  3. An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration. Azzarelli R, et al. Nat Commun, 2014 Feb 27. PMID 24572910, Free PMC Article
  4. Balance between BDNF and Semaphorins gates the innervation of the mammary gland. Sar Shalom H, et al. Elife, 2019 Jan 10. PMID 30628891, Free PMC Article
  5. Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development. Maier V, et al. Mol Cell Neurosci, 2011 Feb. PMID 21122816, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We have identified here Sema4C and Sema4G as candidate ligands for Plexin-B2
    Title: Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
semaphorin-4G

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001413627.1 → NP_001400556.1  semaphorin-4G precursor

    Status: VALIDATED

    Source sequence(s)
    AC132957
    UniProtKB/Swiss-Prot
    Q9WUH7

  2. NM_011976.2 → NP_036106.1  semaphorin-4G precursor

    See identical proteins and their annotated locations for NP_036106.1

    Status: VALIDATED

    Source sequence(s)
    AC132957
    Consensus CDS
    CCDS29853.1
    UniProtKB/Swiss-Prot
    Q9WUH7
    Related
    ENSMUSP00000026225.9, ENSMUST00000026225.15
    Conserved Domains (3) summary
    pfam01437
    Location:505 → 555
    PSI; Plexin repeat
    cd05872
    Location:565 → 648
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:47 → 504
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    44976838..44991836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161601.1 → XP_036017494.1  semaphorin-4G isoform X1

    UniProtKB/Swiss-Prot
    Q9WUH7
    Conserved Domains (3) summary
    pfam01437
    Location:505 → 555
    PSI; Plexin repeat
    cd05872
    Location:565 → 648
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:47 → 504
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  2. XM_036161603.1 → XP_036017496.1  semaphorin-4G isoform X2

    Conserved Domains (3) summary
    pfam01437
    Location:237 → 287
    PSI; Plexin repeat
    cd05872
    Location:297 → 380
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:2 → 236
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

  3. XM_036161604.1 → XP_036017497.1  semaphorin-4G isoform X2

    Conserved Domains (3) summary
    pfam01437
    Location:237 → 287
    PSI; Plexin repeat
    cd05872
    Location:297 → 380
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:2 → 236
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RNA

  1. XR_386476.4 RNA Sequence

  2. XR_386479.2 RNA Sequence

  3. XR_004940150.1 RNA Sequence

  4. XR_003952792.2 RNA Sequence

  5. XR_386477.3 RNA Sequence

  6. XR_004940151.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUH7.1 GenPept UniProtKB/Swiss-Prot:Q9WUH7

Gene LinkOut

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