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Sema4g sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G [ Mus musculus (house mouse) ]

Gene ID: 26456, updated on 23-Jun-2021

Summary

Official Symbol
Sema4gprovided by MGI
Official Full Name
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Gprovided by MGI
Primary source
MGI:MGI:1347047
See related
Ensembl:ENSMUSG00000025207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
AI507908; AW554132
Expression
Biased expression in colon adult (RPKM 249.8), liver adult (RPKM 161.1) and 13 other tissues See more
Orthologs
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Genomic context

See Sema4g in Genome Data Viewer
Location:
19; 19 C3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (44976838..44991836)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (44988743..45003397)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 19 NC_000085.5 (45063834..45077885)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene SMC5-SMC6 complex localization factor 2 Neighboring gene predicted gene, 25482 Neighboring gene RIKEN cDNA 4930414N06 gene Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene twinkle mtDNA helicase Neighboring gene leucine zipper, putative tumor suppressor 2 Neighboring gene PDZ domain containing 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemorepellent activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables semaphorin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of axon extension involved in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neural crest cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in semaphorin-plexin signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011976.1NP_036106.1  semaphorin-4G precursor

    See identical proteins and their annotated locations for NP_036106.1

    Status: VALIDATED

    Source sequence(s)
    AF134918
    Consensus CDS
    CCDS29853.1
    UniProtKB/Swiss-Prot
    Q9WUH7
    Related
    ENSMUSP00000026225.9, ENSMUST00000026225.15
    Conserved Domains (3) summary
    pfam01437
    Location:505555
    PSI; Plexin repeat
    cd05872
    Location:565648
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:47504
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    44976838..44991836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161601.1XP_036017494.1  semaphorin-4G isoform X1

    Conserved Domains (3) summary
    pfam01437
    Location:505555
    PSI; Plexin repeat
    cd05872
    Location:565648
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:47504
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  2. XM_036161603.1XP_036017496.1  semaphorin-4G isoform X2

    Conserved Domains (3) summary
    pfam01437
    Location:237287
    PSI; Plexin repeat
    cd05872
    Location:297380
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:2236
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  3. XM_036161602.1XP_036017495.1  semaphorin-4G isoform X1

    Conserved Domains (3) summary
    pfam01437
    Location:505555
    PSI; Plexin repeat
    cd05872
    Location:565648
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:47504
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
  4. XM_036161604.1XP_036017497.1  semaphorin-4G isoform X2

    Conserved Domains (3) summary
    pfam01437
    Location:237287
    PSI; Plexin repeat
    cd05872
    Location:297380
    Ig_Sema4B_like; Immunoglobulin (Ig)-like domain of the class IV semaphorin Sema4B
    cl15693
    Location:2236
    Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

RNA

  1. XR_386476.4 RNA Sequence

  2. XR_386479.2 RNA Sequence

  3. XR_004940150.1 RNA Sequence

  4. XR_003952792.2 RNA Sequence

  5. XR_386477.3 RNA Sequence

  6. XR_004940151.1 RNA Sequence

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