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Gzma granzyme A [ Rattus norvegicus (Norway rat) ]

Gene ID: 266708, updated on 30-Sep-2021

Summary

Official Symbol
Gzmaprovided by RGD
Official Full Name
granzyme Aprovided by RGD
Primary source
RGD:628640
See related
EnsemblRapid:ENSRNOG00000010603
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
has tryptase activity, binds and is inhibited by pancreatic secretory trypsin inhibitor [RGD, Feb 2006]
Expression
Biased expression in Spleen (RPKM 376.6), Lung (RPKM 311.0) and 4 other tissues See more
Orthologs
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Genomic context

See Gzma in Genome Data Viewer
Location:
2q14
Exon count:
5
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (44740638..44752471, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (44968846..44981436, complement)

Chromosome 2 - NC_051337.1Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase 8 Neighboring gene cell division cycle 20B Neighboring gene granzyme K Neighboring gene endothelial cell-specific molecule 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables serine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153468.1NP_703198.1  granzyme A precursor

    See identical proteins and their annotated locations for NP_703198.1

    Status: PROVISIONAL

    Source sequence(s)
    AB082125
    UniProtKB/TrEMBL
    Q8CJF4
    Related
    ENSRNOP00000014134.1, ENSRNOT00000014134.4
    Conserved Domains (2) summary
    smart00020
    Location:28253
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:29256
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051337.1 Reference mRatBN7.2 Primary Assembly

    Range
    44740638..44752471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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