Rab11fip4 RAB11 family interacting protein 4 (class II) [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab11fip4provided by MGI
Official Full Name: RAB11 family interacting protein 4 (class II)provided by MGI
Primary source: MGI:MGI:2442920
See related: Ensembl:ENSMUSG00000017639 AllianceGenome:MGI:2442920
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: mKIAA1821; RAB11-FIP4; A730072L08Rik
Summary: Predicted to enable protein homodimerization activity and small GTPase binding activity. Acts upstream of or within neural retina development and positive regulation of G1 to G0 transition. Located in perinuclear region of cytoplasm. Is expressed in several structures, including central nervous system; gut; respiratory system; sensory organ; and skeleton. Orthologous to human RAB11FIP4 (RAB11 family interacting protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in cortex adult (RPKM 31.5), frontal lobe adult (RPKM 30.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B5; 11 46.88 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (79481847..79588842)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (79591021..79698016)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FIP4 and FIP3 play overlapping but distinct roles in neuronal migration downstream of Rab11 and Arfophilin-1 during cortical layer formation.
Title: FIP4/Arfophilin-2 plays overlapping but distinct roles from FIP3/Arfophilin-1 in neuronal migration during cortical layer formation.
Rab11-FIP4 expression promotes migration and invasion of colon cancer cells and correlates with poor prognosis.
Title: Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis.
identification of Rab11-family interacting protein 4 (Rab11-FIP4) as a gene strongly expressed in the developing mouse retina.
Title: Mouse Rab11-FIP4 regulates proliferation and differentiation of retinal progenitors in a Rab11-independent manner.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Rab11fip4 (e-PCR), detects polymorphism
- UniSTS:498250

D11Bhm108 (e-PCR), detects polymorphism
- UniSTS:141543

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in endocytic recycling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytokinesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cleavage furrow	IBA Inferred from Biological aspect of Ancestor more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in midbody	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	ISO Inferred from Sequence Orthology more info
is_active_in recycling endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: rab11 family-interacting protein 4

Names: FIP4-Rab11; mRab11-FIP4A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175543.3 → NP_780752.1 rab11 family-interacting protein 4

See identical proteins and their annotated locations for NP_780752.1

Status: PROVISIONAL

Source sequence(s)

AK046734

Consensus CDS

CCDS25123.1

UniProtKB/Swiss-Prot

Q80T87, Q8BQP8

Related

ENSMUSP00000017783.7, ENSMUST00000017783.13

Conserved Domains (3) summary

pfam09457
Location:594 → 634

RBD-FIP; FIP domain

pfam13499
Location:21 → 78

EF-hand_7; EF-hand domain pair

cl03075
Location:426 → 510

GrpE; nucleotide exchange factor GrpE

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

79481847..79588842

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006533403.2 → XP_006533466.1 rab11 family-interacting protein 4 isoform X1

Conserved Domains (3) summary

COG1196
Location:315 → 545

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09457
Location:571 → 611

RBD-FIP; FIP domain

pfam13499
Location:20 → 78

EF-hand_7; EF-hand domain pair
XM_036156717.1 → XP_036012610.1 rab11 family-interacting protein 4 isoform X2

Conserved Domains (2) summary

TIGR02168
Location:278 → 560

SMC_prok_B; chromosome segregation protein SMC, common bacterial type

pfam09457
Location:535 → 575

RBD-FIP; FIP domain
XM_036156719.1 → XP_036012612.1 rab11 family-interacting protein 4 isoform X5

Conserved Domains (1) summary

pfam13499
Location:20 → 78

EF-hand_7; EF-hand domain pair
XM_030246035.2 → XP_030101895.1 rab11 family-interacting protein 4 isoform X4

Conserved Domains (2) summary

COG1196
Location:199 → 429

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09457
Location:455 → 495

RBD-FIP; FIP domain
XM_006533404.4 → XP_006533467.1 rab11 family-interacting protein 4 isoform X3

Conserved Domains (2) summary

COG1196
Location:236 → 466

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam09457
Location:492 → 532

RBD-FIP; FIP domain