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B3galt1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 26877, updated on 5-Mar-2024

Summary

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Official Symbol
B3galt1provided by MGI
Official Full Name
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1provided by MGI
Primary source
MGI:MGI:1349403
See related
Ensembl:ENSMUSG00000034780 AllianceGenome:MGI:1349403
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
beta3Gal-T1
Summary
Enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity. Acts upstream of or within oligosaccharide biosynthetic process. Located in Golgi membrane. Is expressed in nervous system. Orthologous to human B3GALT1 (beta-1,3-galactosyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 4.5), frontal lobe adult (RPKM 4.2) and 10 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 C1.3; 2 39.53 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (67395528..67953226)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (67565689..68122882)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 23328 Neighboring gene xin actin-binding repeat containing 2 Neighboring gene predicted gene 13601 Neighboring gene VISTA enhancer mm1717 Neighboring gene microRNA 7224 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene microRNA 6335 Neighboring gene predicted gene, 54157 Neighboring gene STARR-seq mESC enhancer starr_04706 Neighboring gene actin-like 6A pseudogene Neighboring gene STARR-seq mESC enhancer starr_04707 Neighboring gene STARR-seq mESC enhancer starr_04708 Neighboring gene STARR-seq mESC enhancer starr_04709 Neighboring gene STARR-seq mESC enhancer starr_04712 Neighboring gene serine/threonine kinase 39 Neighboring gene predicted gene, 54158 Neighboring gene predicted gene 13596

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Developmental regulation of beta-1,3-galactosyltransferase-1 gene expression in mouse brain. Zhu D, et al. FEBS Lett, 2003 Mar 13. PMID 12633872
  2. Functional assignment of motifs conserved in beta 1,3-glycosyltransferases. Malissard M, et al. Eur J Biochem, 2002 Jan. PMID 11784317
  3. Genomic cloning and expression of three murine UDP-galactose: beta-N-acetylglucosamine beta1,3-galactosyltransferase genes. Hennet T, et al. J Biol Chem, 1998 Jan 2. PMID 9417047
  4. Proteomics characterization of abundant Golgi membrane proteins. Bell AW, et al. J Biol Chem, 2001 Feb 16. PMID 11042173
  5. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables glucosaminylgalactosylglucosylceramide beta-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hexosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in galactosylceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within oligosaccharide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,3-galactosyltransferase 1
Names
UDP-galactose:beta-N-acetylglucosamine beta1, 3-galactosyltransferase 1
beta-1,3-GalTase 1
NP_001366253.1
NP_001366254.1
NP_001366255.1
NP_001366256.1
NP_001366257.1
NP_001366258.1
NP_001399338.1
NP_001399339.1
NP_064679.2
XP_036018121.1
XP_036018122.1
XP_036018123.1
XP_036018124.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001379324.1 → NP_001366253.1  beta-1,3-galactosyltransferase 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-8 and 11 all encode the same protein.
    Source sequence(s)
    AL845519, AL928598, AL929125, AL929411, BX936296
    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 279
    Galactosyl_T; Galactosyltransferase

  2. NM_001379325.1 → NP_001366254.1  beta-1,3-galactosyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AL845519, AL928598, AL929125, AL929411, BX936296
    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 279
    Galactosyl_T; Galactosyltransferase

  3. NM_001379326.1 → NP_001366255.1  beta-1,3-galactosyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AL845519, AL928598, AL929125, AL929411, BX936296
    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 279
    Galactosyl_T; Galactosyltransferase

  4. NM_001379327.1 → NP_001366256.1  beta-1,3-galactosyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AL845519, AL928598, AL929125, AL929411, BX936296
    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 279
    Galactosyl_T; Galactosyltransferase

  5. NM_001379328.1 → NP_001366257.1  beta-1,3-galactosyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AL928598, AL929125, AL929411, BX936296
    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 279
    Galactosyl_T; Galactosyltransferase

  6. NM_001379329.1 → NP_001366258.1  beta-1,3-galactosyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AL845519, AL928598, AL929125, AL929411, BX936296
    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 279
    Galactosyl_T; Galactosyltransferase

  7. NM_001412409.1 → NP_001399338.1  beta-1,3-galactosyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AL845519, AL928598, AL929125, AL929411, BX936296
    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3

  8. NM_001412410.1 → NP_001399339.1  beta-1,3-galactosyltransferase 1

    Status: VALIDATED

    Source sequence(s)
    AL845519, AL928598, AL929125, AL929411, BX936296
    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3

  9. NM_020283.4 → NP_064679.2  beta-1,3-galactosyltransferase 1

    See identical proteins and their annotated locations for NP_064679.2

    Status: VALIDATED

    Source sequence(s)
    AK035215, BC094660, BX936296
    Consensus CDS
    CCDS16083.1
    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3
    Related
    ENSMUSP00000041343.4, ENSMUST00000042456.4
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 279
    Galactosyl_T; Galactosyltransferase

RNA

  1. NR_178190.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL929125, AL929411

  2. NR_178191.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL929125, AL929411

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    67395528..67953226
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162229.1 → XP_036018122.1  beta-1,3-galactosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 279
    Galactosyl_T; Galactosyltransferase

  2. XM_036162230.1 → XP_036018123.1  beta-1,3-galactosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 279
    Galactosyl_T; Galactosyltransferase

  3. XM_036162231.1 → XP_036018124.1  beta-1,3-galactosyltransferase 1 isoform X2

  4. XM_036162228.1 → XP_036018121.1  beta-1,3-galactosyltransferase 1 isoform X1

    UniProtKB/Swiss-Prot
    O54904, Q91V52
    UniProtKB/TrEMBL
    Q505A3
    Conserved Domains (1) summary
    pfam01762
    Location:92 → 279
    Galactosyl_T; Galactosyltransferase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54904.2 GenPept UniProtKB/Swiss-Prot:O54904

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