Format

Send to:

Choose Destination

Casp8ap2 caspase 8 associated protein 2 [ Mus musculus (house mouse) ]

Gene ID: 26885, updated on 16-Oct-2021

Summary

Official Symbol
Casp8ap2provided by MGI
Official Full Name
caspase 8 associated protein 2provided by MGI
Primary source
MGI:MGI:1349399
See related
Ensembl:ENSMUSG00000028282
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FLASH; D4Ertd659e
Expression
Broad expression in CNS E11.5 (RPKM 6.6), placenta adult (RPKM 3.7) and 17 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Casp8ap2 in Genome Data Viewer
Location:
4 A5; 4 14.27 cM
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (32615462..32653271)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (32615470..32653271)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (32702448..32740240)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene BTB and CNC homology, basic leucine zipper transcription factor 2 Neighboring gene BTB and CNC homology 2, opposite strand Neighboring gene gap junction protein, alpha 10 Neighboring gene midasin AAA ATPase 1 Neighboring gene LYR motif containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • mKIAA1315

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SUMO polymer binding ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type endopeptidase activator activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protease binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in PML body IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
CASP8-associated protein 2
Names
FLICE-associated huge protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122978.2NP_001116450.1  CASP8-associated protein 2

    See identical proteins and their annotated locations for NP_001116450.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK142148, AL805973, CA526466
    Consensus CDS
    CCDS18016.1
    UniProtKB/Swiss-Prot
    Q9WUF3
    UniProtKB/TrEMBL
    Q3UQU1
    Related
    ENSMUSP00000136016.2, ENSMUST00000178925.8
    Conserved Domains (3) summary
    cd12202
    Location:18961960
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    TIGR04313
    Location:10361156
    aro_clust_Mycop; aromatic cluster surface protein
    cl23720
    Location:75142
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. NM_011997.3NP_036127.2  CASP8-associated protein 2

    See identical proteins and their annotated locations for NP_036127.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL805973, AL954737
    Consensus CDS
    CCDS18016.1
    UniProtKB/Swiss-Prot
    Q9WUF3
    Related
    ENSMUSP00000029950.4, ENSMUST00000029950.10
    Conserved Domains (3) summary
    cd12202
    Location:18961960
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    TIGR04313
    Location:10361156
    aro_clust_Mycop; aromatic cluster surface protein
    cl23720
    Location:75142
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    32615462..32653271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006537949.2XP_006538012.1  CASP8-associated protein 2 isoform X1

    Conserved Domains (3) summary
    cd12202
    Location:19402004
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    TIGR04313
    Location:10801200
    aro_clust_Mycop; aromatic cluster surface protein
    cl23720
    Location:119186
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
  2. XM_006537950.3XP_006538013.1  CASP8-associated protein 2 isoform X2

    Conserved Domains (3) summary
    cd12202
    Location:19382002
    CASP8AP2; Caspase 8-associated protein 2 myb-like domain
    TIGR04313
    Location:10781198
    aro_clust_Mycop; aromatic cluster surface protein
    cl23720
    Location:126184
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
Support Center