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Cops7a COP9 signalosome subunit 7A [ Mus musculus (house mouse) ]

Gene ID: 26894, updated on 3-Apr-2024

Summary

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Official Symbol
Cops7aprovided by MGI
Official Full Name
COP9 signalosome subunit 7Aprovided by MGI
Primary source
MGI:MGI:1349400
See related
Ensembl:ENSMUSG00000030127 AllianceGenome:MGI:1349400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SGN7a; D6Ertd35e
Summary
Predicted to be involved in protein deneddylation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of COP9 signalosome. Is expressed in several structures, including adipose tissue; alimentary system; brain; eye; and genitourinary system. Orthologous to human COPS7A (COP9 signalosome subunit 7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 98.1), adrenal adult (RPKM 67.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 F2; 6 59.17 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (124935413..124974866, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (124958445..124997903, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A230083G16 gene Neighboring gene STARR-seq mESC enhancer starr_17314 Neighboring gene predicted gene, 38896 Neighboring gene STARR-positive B cell enhancer ABC_E8969 Neighboring gene STARR-seq mESC enhancer starr_17317 Neighboring gene myeloid leukemia factor 2 Neighboring gene STARR-seq mESC enhancer starr_17318 Neighboring gene STARR-seq mESC enhancer starr_17319 Neighboring gene STARR-positive B cell enhancer ABC_E3682 Neighboring gene STARR-seq mESC enhancer starr_17320 Neighboring gene predicted gene, 23851 Neighboring gene STARR-seq mESC enhancer starr_17322 Neighboring gene STARR-positive B cell enhancer ABC_E6488 Neighboring gene RIKEN cDNA 4930557K07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1711 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:124959611-124959720 Neighboring gene PILR alpha associated neural protein Neighboring gene zinc finger protein 384 Neighboring gene STARR-positive B cell enhancer ABC_E1071 Neighboring gene STARR-seq mESC enhancer starr_17323 Neighboring gene STARR-positive B cell enhancer ABC_E6489 Neighboring gene inhibitor of growth family, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression, purification and crystallization of a PCI domain from the COP9 signalosome subunit 7 (CSN7). Dessau M, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Nov 1. PMID 17077498, Free PMC Article
  2. Mechanism of exogenous nucleic acids and their precursors improving the repair of intestinal epithelium after gamma-irradiation in mice. Cui DX, et al. World J Gastroenterol, 2000 Oct. PMID 11819679, Free PMC Article
  3. Ubiquitin-dependent degradation of Id1 and Id3 is mediated by the COP9 signalosome. Berse M, et al. J Mol Biol, 2004 Oct 15. PMID 15451666
  4. The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein. Zarich N, et al. Oncogenesis, 2019 Jan 4. PMID 30631038, Free PMC Article
  5. COP9 Signalosome Subunit 3 Restricts Neuroinflammatory Responses During Cerebral Ischemia/Reperfusion Injury Through Stabilizing Suppressor of Cytokine Signaling 3 Protein. Liang E, et al. Neuropsychiatr Dis Treat, 2021. PMID 33911869, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. This protein was purified to homogeneity and screened for crystallization.
    Title: Expression, purification and crystallization of a PCI domain from the COP9 signalosome subunit 7 (CSN7).
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in COP9 signalosome assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 7a
Names
COP9 (constitutive photomorphogenic) homolog, subunit 7a
COP9 (constitutive photomorphogenic), subunit 7a
COP9 complex S7a
JAB1-containing signalosome subunit 7a
signalosome subunit 7a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164089.3 → NP_001157561.1  COP9 signalosome complex subunit 7a isoform 2

    See identical proteins and their annotated locations for NP_001157561.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate 5' UTR, and has a distinct 3' terminal exon and UTR, compared to variant 1. The resulting isoform (2) has a longer and distinct C-terminus, compared to isoform 1. Variants 2, 7-10, and 12 all encode the same isoform (2).
    Source sequence(s)
    AC164563
    Consensus CDS
    CCDS51909.1
    UniProtKB/TrEMBL
    D3Z440
    Related
    ENSMUSP00000108058.3, ENSMUST00000112439.9
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  2. NM_001355541.2 → NP_001342470.1  COP9 signalosome complex subunit 7a isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164563
    Consensus CDS
    CCDS20539.1
    UniProtKB/Swiss-Prot
    O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
    UniProtKB/TrEMBL
    D3Z440
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  3. NM_001355542.2 → NP_001342471.1  COP9 signalosome complex subunit 7a isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents use of an alternate 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1, 3-6, and 11 all encode the same isoform (1).
    Source sequence(s)
    AC164563
    Consensus CDS
    CCDS20539.1
    UniProtKB/Swiss-Prot
    O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
    UniProtKB/TrEMBL
    D3Z440
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  4. NM_001379119.1 → NP_001366048.1  COP9 signalosome complex subunit 7a isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164563
    UniProtKB/Swiss-Prot
    O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
    UniProtKB/TrEMBL
    D3Z440
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  5. NM_001379120.1 → NP_001366049.1  COP9 signalosome complex subunit 7a isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164563
    UniProtKB/Swiss-Prot
    O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
    UniProtKB/TrEMBL
    D3Z440
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  6. NM_001379122.1 → NP_001366051.1  COP9 signalosome complex subunit 7a isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164563
    UniProtKB/TrEMBL
    D3Z440
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  7. NM_001379123.1 → NP_001366052.1  COP9 signalosome complex subunit 7a isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164563
    UniProtKB/TrEMBL
    D3Z440
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  8. NM_001379124.1 → NP_001366053.1  COP9 signalosome complex subunit 7a isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164563
    UniProtKB/TrEMBL
    D3Z440
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  9. NM_001379125.1 → NP_001366054.1  COP9 signalosome complex subunit 7a isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164563
    UniProtKB/TrEMBL
    D3Z440
    Related
    ENSMUSP00000117584.2, ENSMUST00000129976.8
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

  10. NM_001410594.1 → NP_001397523.1  COP9 signalosome complex subunit 7a isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC164563
    UniProtKB/Swiss-Prot
    O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04

  11. NM_001410595.1 → NP_001397524.1  COP9 signalosome complex subunit 7a isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164563

  12. NM_012003.4 → NP_036133.1  COP9 signalosome complex subunit 7a isoform 1

    See identical proteins and their annotated locations for NP_036133.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 3-6, and 11 all encode the same isoform (1).
    Source sequence(s)
    AC164563
    Consensus CDS
    CCDS20539.1
    UniProtKB/Swiss-Prot
    O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
    UniProtKB/TrEMBL
    D3Z440
    Related
    ENSMUSP00000032220.9, ENSMUST00000032220.15
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    124935413..124974866 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030255406.2 → XP_030111266.1  COP9 signalosome complex subunit 7a isoform X2

    UniProtKB/Swiss-Prot
    O88546, Q925R8, Q9CPQ4, Q9CWD2, Q9CZ04
    UniProtKB/TrEMBL
    D3Z440
    Conserved Domains (2) summary
    smart00088
    Location:87 → 177
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    pfam18392
    Location:166 → 215
    CSN7a_helixI; COP9 signalosome complex subunit 7a helix I domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9CZ04.2 GenPept UniProtKB/Swiss-Prot:Q9CZ04

Gene LinkOut

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