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Map4k4 mitogen-activated protein kinase kinase kinase kinase 4 [ Mus musculus (house mouse) ]

Gene ID: 26921, updated on 21-Apr-2024

Summary

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Official Symbol
Map4k4provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase kinase 4provided by MGI
Primary source
MGI:MGI:1349394
See related
Ensembl:ENSMUSG00000026074 AllianceGenome:MGI:1349394
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HGK; Nik; 9430080K19Rik
Summary
Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell-substrate junction organization; positive regulation of intracellular signal transduction; and positive regulation of keratinocyte migration. Located in focal adhesion. Is expressed in several structures, including genitourinary system; molar; nervous system; neural retina; and skin. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E14 (RPKM 64.6), CNS E11.5 (RPKM 64.4) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 18.53 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (39939806..40065470)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (39900902..40026310)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700066B17 gene Neighboring gene STARR-seq mESC enhancer starr_00730 Neighboring gene predicted gene, 35600 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39952403-39952658 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39953411-39953598 Neighboring gene STARR-seq mESC enhancer starr_00731 Neighboring gene STARR-seq mESC enhancer starr_00732 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:39991996-39992105 Neighboring gene STARR-positive B cell enhancer ABC_E9463 Neighboring gene VISTA enhancer mm1333 Neighboring gene STARR-positive B cell enhancer mm9_chr1:40142581-40142881 Neighboring gene predicted gene, 16894 Neighboring gene STARR-seq mESC enhancer starr_00736 Neighboring gene interleukin 1 receptor, type II Neighboring gene predicted gene, 35741

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Ste20 Family Kinases MAP4K4, MINK1, and TNIK Converge to Regulate Stress-Induced JNK Signaling in Neurons. Larhammar M, et al. J Neurosci, 2017 Nov 15. PMID 28993483, Free PMC Article
  2. Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity. Roth Flach RJ, et al. Am J Physiol Endocrinol Metab, 2017 Sep 1. PMID 28611026, Free PMC Article
  3. Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia. Roth Flach RJ, et al. J Biol Chem, 2016 Jul 29. PMID 27226575, Free PMC Article
  4. MAP4K4 deletion inhibits proliferation and activation of CD4(+) T cell and promotes T regulatory cell generation in vitro. Huang H, et al. Cell Immunol, 2014 May-Jun. PMID 24681727
  5. Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation. Aouadi M, et al. Nature, 2009 Apr 30. PMID 19407801, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways.
    Title: Dichotomous role of the serine/threonine kinase MAP4K4 in pancreatic ductal adenocarcinoma onset and metastasis through control of AKT and ERK pathways.
  2. MAP4K4 is involved in the neuronal development of retinal photoreceptors.
    Title: MAP4K4 is involved in the neuronal development of retinal photoreceptors.
  3. Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.
    Title: Vascular smooth muscle RhoA counteracts abdominal aortic aneurysm formation by modulating MAP4K4 activity.
  4. These studies highlight a MAP4K4-initiated signaling cascade that induces motor neuron degeneration.
    Title: MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis.
  5. TLR4-MAP4K4 pathway can regulate retinal neovascularization.
    Title: Role of TLR4-MAP4K4 signaling pathway in models of oxygen-induced retinopathy.
  6. Study identified a novel splicing network composed of RBM4a, SRSF3, and MAP4K4 in brown adipogenesis and subsequently manipulating the effect of downstream JNK signaling which contributes to insulin resistance and reduced metabolism.
    Title: RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis.
  7. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells.
    Title: FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway.
  8. Blood endothelial Map4k4 promotes vascular dysfunction and impairs glucose homeostasis in adult animals, lymphatic endothelial Map4k4 is required to maintain lymphatic vascular integrity and regulate immune cell trafficking in obesity.
    Title: Map4k4 impairs energy metabolism in endothelial cells and promotes insulin resistance in obesity.
  9. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate.
    Title: Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function.
  10. These results demonstrate that protein kinase Map4k4 drives obesity-induced hyperinsulinemia and insulin resistance in part by promoting insulin secretion from beta cells in mice.
    Title: Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables creatine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection regeneration ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ARF protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of JNK cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of focal adhesion assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of focal adhesion disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of keratinocyte migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase kinase 4
Names
HPK/GCK-like kinase HGK
MAPK/ERK kinase kinase kinase 4
MEK kinase kinase 4
MEKKK 4
NCK interacting kinase
nck-interacting kinase
NP_001239129.1
NP_001239130.1
NP_001239131.1
NP_032722.2
XP_006496104.1
XP_006496105.1
XP_006496106.1
XP_006496108.1
XP_006496109.1
XP_011236832.1
XP_017176483.1
XP_017176487.1
XP_017176490.1
XP_017176491.1
XP_017176493.1
XP_017176499.1
XP_017176500.1
XP_017176502.1
XP_017176507.1
XP_017176510.1
XP_030110570.1
XP_030110580.1
XP_036021388.1
XP_036021391.1
XP_036021394.1
XP_036021398.1
XP_036021400.1
XP_036021407.1
XP_036021415.1
XP_036021418.1
XP_036021421.1
XP_036021424.1
XP_036021426.1
XP_036021430.1
XP_036021432.1
XP_036021435.1
XP_036021436.1
XP_036021440.1
XP_036021441.1
XP_036021442.1
XP_036021443.1
XP_036021445.1
XP_036021446.1
XP_036021449.1
XP_036021450.1
XP_036021454.1
XP_036021456.1
XP_036021458.1
XP_036021460.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252200.1 → NP_001239129.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK159799, AV445090, BB651050, BC145390, BF721981, BQ571658, CJ142598, U88984
    Consensus CDS
    CCDS78573.1
    UniProtKB/TrEMBL
    A0A0A6YW53, B7ZNR8
    Related
    ENSMUSP00000141400.2, ENSMUST00000195860.6
    Conserved Domains (3) summary
    smart00036
    Location:970 → 1268
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  2. NM_001252201.1 → NP_001239130.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 3

    See identical proteins and their annotated locations for NP_001239130.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences in the presence and absence of in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (3), compared to isoform 1.
    Source sequence(s)
    AK159799, AV445090, BB651050, BC141109, BC145390, BF721981, BQ571658, CJ142598, U88984
    Consensus CDS
    CCDS78576.1
    UniProtKB/Swiss-Prot
    P97820
    UniProtKB/TrEMBL
    B2RUE8
    Related
    ENSMUSP00000141862.2, ENSMUST00000193682.6
    Conserved Domains (3) summary
    smart00036
    Location:903 → 1201
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  3. NM_001252202.1 → NP_001239131.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform 4

    See identical proteins and their annotated locations for NP_001239131.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (4), compared to isoform 1.
    Source sequence(s)
    AK159799, AV445090, BB651050, BC145390, BC145391, BF721981, BQ571658, CJ142598, U88984
    Consensus CDS
    CCDS78575.1
    UniProtKB/TrEMBL
    B7ZNR9, F8VPL5
    Related
    ENSMUSP00000142056.2, ENSMUST00000195259.6
    Conserved Domains (3) summary
    smart00036
    Location:890 → 1188
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  4. NM_008696.2 → NP_032722.2  mitogen-activated protein kinase kinase kinase kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_032722.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple in-frame exons in the central coding region, compared to variant 1, and encodes a shorter isoform (2), compared to isoform 1.
    Source sequence(s)
    AC132909, AC166238, AK138966, CF531764, U88984
    Consensus CDS
    CCDS35546.1
    UniProtKB/Swiss-Prot
    P97820
    UniProtKB/TrEMBL
    A0A0A6YWR8
    Related
    ENSMUSP00000141665.2, ENSMUST00000192509.6
    Conserved Domains (3) summary
    smart00036
    Location:916 → 1214
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    smart00220
    Location:25 → 289
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    39939806..40065470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496041.3 → XP_006496104.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:1065 → 1363
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  2. XM_011238530.3 → XP_011236832.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X15

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:1001 → 1299
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  3. XM_017321001.3 → XP_017176490.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X4

    UniProtKB/TrEMBL
    E9PVG7
    Conserved Domains (2) summary
    smart00036
    Location:1062 → 1360
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  4. XM_017321010.3 → XP_017176499.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X16

    UniProtKB/TrEMBL
    E9PVG7
    Conserved Domains (2) summary
    smart00036
    Location:998 → 1296
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  5. XM_017320994.3 → XP_017176483.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:1064 → 1362
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  6. XM_017320998.3 → XP_017176487.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X3

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:1063 → 1361
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  7. XM_036165495.1 → XP_036021388.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X5

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:1062 → 1360
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  8. XM_017321011.3 → XP_017176500.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X17

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:988 → 1286
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  9. XM_036165549.1 → XP_036021442.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X34

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:924 → 1222
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  10. XM_036165525.1 → XP_036021418.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X19

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:985 → 1283
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  11. XM_036165522.1 → XP_036021415.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X18

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:987 → 1285
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  12. XM_006496042.3 → XP_006496105.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X11

    UniProtKB/TrEMBL
    Q6ZQ68
    Conserved Domains (2) summary
    smart00036
    Location:1011 → 1309
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  13. XM_036165537.1 → XP_036021430.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X26

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:947 → 1245
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  14. XM_030254710.2 → XP_030110570.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X12

    UniProtKB/TrEMBL
    Q6ZQ68
    Conserved Domains (2) summary
    smart00036
    Location:1010 → 1308
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  15. XM_036165539.1 → XP_036021432.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X27

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:946 → 1244
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  16. XM_017321004.3 → XP_017176493.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X13

    UniProtKB/TrEMBL
    Q6ZQ68
    Conserved Domains (2) summary
    smart00036
    Location:1009 → 1307
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  17. XM_036165542.1 → XP_036021435.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X28

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:945 → 1243
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  18. XM_036165514.1 → XP_036021407.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X14

    UniProtKB/TrEMBL
    Q6ZQ68
    Conserved Domains (2) summary
    smart00036
    Location:1008 → 1306
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  19. XM_036165543.1 → XP_036021436.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X29

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:944 → 1242
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  20. XM_017321018.3 → XP_017176507.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X30

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:934 → 1232
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  21. XM_036165557.1 → XP_036021450.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X40

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:870 → 1168
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  22. XM_017321021.3 → XP_017176510.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X32

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:931 → 1229
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  23. XM_036165563.1 → XP_036021456.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X42

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:867 → 1165
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  24. XM_036165547.1 → XP_036021440.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X31

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:933 → 1231
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  25. XM_036165561.1 → XP_036021454.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X41

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:869 → 1167
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  26. XM_036165548.1 → XP_036021441.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X33

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:930 → 1228
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  27. XM_017321002.3 → XP_017176491.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X6

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:1034 → 1332
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  28. XM_036165505.1 → XP_036021398.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X9

    UniProtKB/TrEMBL
    E9PVG7
    Conserved Domains (2) summary
    smart00036
    Location:1031 → 1329
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  29. XM_036165533.1 → XP_036021426.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X24

    UniProtKB/TrEMBL
    E9PVG7
    Related
    ENSMUSP00000126961.3, ENSMUST00000163854.9
    Conserved Domains (2) summary
    smart00036
    Location:967 → 1265
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  30. XM_036165498.1 → XP_036021391.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X7

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:1033 → 1331
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  31. XM_036165501.1 → XP_036021394.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X8

    UniProtKB/TrEMBL
    B7ZNR8
    Conserved Domains (2) summary
    smart00036
    Location:1032 → 1330
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  32. XM_036165507.1 → XP_036021400.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X10

    UniProtKB/TrEMBL
    E9PVG7
    Conserved Domains (2) summary
    smart00036
    Location:1029 → 1327
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  33. XM_006496045.3 → XP_006496108.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X39

    UniProtKB/TrEMBL
    F8VPL5
    Conserved Domains (2) summary
    smart00036
    Location:893 → 1191
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  34. XM_006496043.3 → XP_006496106.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X25

    UniProtKB/TrEMBL
    A0A0A6YWM8, F8VPL5
    Related
    ENSMUSP00000141613.2, ENSMUST00000195636.6
    Conserved Domains (2) summary
    smart00036
    Location:954 → 1252
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  35. XM_017321013.3 → XP_017176502.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X20

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:980 → 1278
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  36. XM_030254720.2 → XP_030110580.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X22

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:977 → 1275
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  37. XM_036165552.1 → XP_036021445.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X36

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:913 → 1211
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  38. XM_036165528.1 → XP_036021421.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X21

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:979 → 1277
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  39. XM_036165550.1 → XP_036021443.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X35

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:915 → 1213
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  40. XM_036165531.1 → XP_036021424.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X23

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:976 → 1274
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  41. XM_036165565.1 → XP_036021458.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X43

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:839 → 1137
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  42. XM_036165556.1 → XP_036021449.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X38

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:900 → 1198
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  43. XM_036165567.1 → XP_036021460.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X45

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:836 → 1134
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  44. XM_036165553.1 → XP_036021446.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X37

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:902 → 1200
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

  45. XM_006496046.3 → XP_006496109.1  mitogen-activated protein kinase kinase kinase kinase 4 isoform X44

    UniProtKB/Swiss-Prot
    P97820
    Conserved Domains (2) summary
    smart00036
    Location:838 → 1136
    CNH; Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
    cl21453
    Location:8 → 289
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_001784729.3 RNA Sequence

  2. XR_003955681.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97820.1 GenPept UniProtKB/Swiss-Prot:P97820

Gene LinkOut

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