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Acvr1c activin A receptor, type IC [ Mus musculus (house mouse) ]

Gene ID: 269275, updated on 16-Oct-2021

Summary

Official Symbol
Acvr1cprovided by MGI
Official Full Name
activin A receptor, type ICprovided by MGI
Primary source
MGI:MGI:2661081
See related
Ensembl:ENSMUSG00000026834
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALK7; Alk-7; ACTR-IC; ACVRLK7; C230097P10
Expression
Biased expression in subcutaneous fat pad adult (RPKM 3.9), genital fat pad adult (RPKM 2.9) and 8 other tissues See more
Orthologs
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Genomic context

See Acvr1c in Genome Data Viewer
Location:
2; 2 C1.1
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (58157465..58247909, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (58267453..58357896, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (58119864..58210169, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 15 pseudogene Neighboring gene cytohesin 1 interacting protein Neighboring gene predicted gene 13546 Neighboring gene predicted gene 13544 Neighboring gene 60S ribosomal protein L29 pseudogene Neighboring gene predicted gene, 50616 Neighboring gene VISTA enhancer mm1599 Neighboring gene activin A receptor, type 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables BMP receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
NOT enables activin binding ISO
Inferred from Sequence Orthology
more info
 
enables activin binding ISO
Inferred from Sequence Orthology
more info
 
enables activin receptor activity, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables activin receptor activity, type I ISO
Inferred from Sequence Orthology
more info
 
enables growth factor binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nodal binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in activin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in apoptotic nuclear changes ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NOT acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT acts_upstream_of_or_within in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of chorionic trophoblast cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of trophoblast cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in nodal signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to dietary excess IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to glucose IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to insulin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transforming growth factor beta receptor complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in transmembrane receptor protein serine/threonine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within trophectodermal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
part_of activin receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of activin receptor complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
activin receptor type-1C
Names
activin receptor type IC
activin receptor-like kinase 7
NP_001028541.1
NP_001104500.1
XP_006498148.1
XP_006498149.1
XP_011237410.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033369.3NP_001028541.1  activin receptor type-1C isoform 2

    See identical proteins and their annotated locations for NP_001028541.1

    Status: VALIDATED

    Source sequence(s)
    AI643872, AK049089, AL772179
    Consensus CDS
    CCDS16049.1
    UniProtKB/TrEMBL
    Q3V348
    Related
    ENSMUSP00000097663.2, ENSMUST00000100085.8
    Conserved Domains (3) summary
    cd14143
    Location:69356
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:545
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:5163
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  2. NM_001111030.1NP_001104500.1  activin receptor type-1C isoform 1 precursor

    See identical proteins and their annotated locations for NP_001104500.1

    Status: VALIDATED

    Source sequence(s)
    AI643872, AK142396, AL772179, BC028780
    Consensus CDS
    CCDS50586.1
    UniProtKB/Swiss-Prot
    Q8K348
    Related
    ENSMUSP00000028178.8, ENSMUST00000028178.14
    Conserved Domains (4) summary
    cd14143
    Location:199486
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:27100
    Activin_recp; Activin types I and II receptor domain
    pfam07714
    Location:195474
    Pkinase_Tyr; Protein tyrosine kinase
    pfam08515
    Location:166193
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    58157465..58247909 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498086.5XP_006498149.1  activin receptor type-1C isoform X2

    See identical proteins and their annotated locations for XP_006498149.1

    UniProtKB/TrEMBL
    A2AJR5
    Related
    ENSMUSP00000108227.3, ENSMUST00000112608.9
    Conserved Domains (3) summary
    cd14143
    Location:119406
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:2795
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:101113
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  2. XM_011239108.2XP_011237410.1  activin receptor type-1C isoform X1

    See identical proteins and their annotated locations for XP_011237410.1

    Conserved Domains (3) summary
    cd14143
    Location:149436
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:145
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:116143
    TGF_beta_GS; Transforming growth factor beta type I GS-motif
  3. XM_006498085.5XP_006498148.1  activin receptor type-1C isoform X1

    See identical proteins and their annotated locations for XP_006498148.1

    Conserved Domains (3) summary
    cd14143
    Location:149436
    STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
    pfam01064
    Location:145
    Activin_recp; Activin types I and II receptor domain
    pfam08515
    Location:116143
    TGF_beta_GS; Transforming growth factor beta type I GS-motif

RNA

  1. XR_374097.5 RNA Sequence

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