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Slc28a2 solute carrier family 28 (sodium-coupled nucleoside transporter), member 2 [ Mus musculus (house mouse) ]

Gene ID: 269346, updated on 11-Apr-2024

Summary

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Official Symbol
Slc28a2provided by MGI
Official Full Name
solute carrier family 28 (sodium-coupled nucleoside transporter), member 2provided by MGI
Primary source
MGI:MGI:1913105
See related
Ensembl:ENSMUSG00000027219 AllianceGenome:MGI:1913105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cnt2; SPNT; B430217P18; 2010208B10Rik
Summary
Enables purine nucleoside transmembrane transporter activity. Predicted to be involved in several processes, including nucleoside transport; protein localization to cell surface; and purine nucleobase transmembrane transport. Located in brush border membrane. Is expressed in foregut-midgut junction; midgut; and placenta. Orthologous to human SLC28A2 (solute carrier family 28 member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in small intestine adult (RPKM 25.8), large intestine adult (RPKM 20.5) and 7 other tissues See more
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Genomic context

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Location:
2 E5; 2 60.63 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (122256836..122291633)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (122426357..122461152)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39918 Neighboring gene nuclear encoded tRNA histidine 5 (anticodon GTG) Neighboring gene predicted gene, 24409 Neighboring gene STARR-positive B cell enhancer mm9_chr2:122234690-122234991 Neighboring gene STARR-positive B cell enhancer ABC_E7855 Neighboring gene BMP and activin membrane-bound inhibitor, pseudogene (Xenopus laevis) Neighboring gene solute carrier family 28 member 2b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cytidine is a novel substrate for wild-type concentrative nucleoside transporter 2. Nagai K, et al. Biochem Biophys Res Commun, 2006 Aug 25. PMID 16828706
  2. Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2. Yong T, et al. Am J Chin Med, 2018. PMID 29595077
  3. Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes. Furihata T, et al. Antimicrob Agents Chemother, 2010 Jul. PMID 20421393, Free PMC Article
  4. TGF-beta transcriptionally activates the gene encoding the high-affinity adenosine transporter CNT2 in rat liver parenchymal cells. Valdés R, et al. Cell Mol Life Sci, 2006 Nov. PMID 17013559
  5. Cloning, genomic organization and chromosomal localization of the gene encoding the murine sodium-dependent, purine-selective, concentrative nucleoside transporter (CNT2). Patel DH, et al. Gene, 2000 Jan 25. PMID 10721696

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells.
    Title: The scaffold protein PDZK1 governs diurnal localization of CNT2 on the plasma membrane in mouse intestinal epithelial cells.
  2. It is a purine nucleoside preferring transporter playing a central role in the gastrointestinal absorption of purines in the enterocytes.
    Title: Hypouricemic Effects of Armillaria mellea on Hyperuricemic Mice Regulated through OAT1 and CNT2.
  3. Data concluded that CNT2 contributes considerably to nucleoside uptake in rat hepatocytes but not in mouse hepatocytes.
    Title: Striking species difference in the contribution of concentrative nucleoside transporter 2 to nucleoside uptake between mouse and rat hepatocytes.
  4. TGF-beta1 transcriptionally activates the CNT2-encoding gene in a JNK-dependent manner.
    Title: TGF-beta transcriptionally activates the gene encoding the high-affinity adenosine transporter CNT2 in rat liver parenchymal cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables neurotransmitter transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleoside:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables purine nucleobase transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables purine nucleoside transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables purine nucleoside transmembrane transporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables purine nucleoside transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables pyrimidine- and adenosine-specific:sodium symporter activity ISO
Inferred from Sequence Orthology
more info
  
enables uridine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in adenosine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in inosine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neurotransmitter transport ISO
Inferred from Sequence Orthology
more info
  
involved_in nucleoside transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleoside transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to cell surface ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleobase transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in purine nucleoside transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within purine nucleoside transmembrane transport TAS
Traceable Author Statement
more info
 PubMed 
involved_in pyrimidine-containing compound transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in retina homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retina homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in uridine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apicolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in brush border membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in coated vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in vesicle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
sodium/nucleoside cotransporter 2
Names
Na(+)/nucleoside cotransporter 2
concentrative nucleoside transporter 2
purine-selective Na+ nucleoside cotransporter
sodium/purine nucleoside cotransporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356532.3 → NP_001343461.1  sodium/nucleoside cotransporter 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AL844566
    Consensus CDS
    CCDS16663.1
    UniProtKB/Swiss-Prot
    O88627, Q8BJP1
    UniProtKB/TrEMBL
    Q7TMQ0
    Conserved Domains (1) summary
    TIGR00804
    Location:176 → 587
    nupC; nucleoside transporter

  2. NM_001379459.1 → NP_001366388.1  sodium/nucleoside cotransporter 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AL844566
    UniProtKB/Swiss-Prot
    O88627, Q8BJP1
    UniProtKB/TrEMBL
    Q7TMQ0
    Conserved Domains (1) summary
    TIGR00804
    Location:176 → 587
    nupC; nucleoside transporter

  3. NM_001379460.1 → NP_001366389.1  sodium/nucleoside cotransporter 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AL844566
    UniProtKB/Swiss-Prot
    O88627, Q8BJP1
    UniProtKB/TrEMBL
    Q7TMQ0
    Conserved Domains (1) summary
    TIGR00804
    Location:176 → 587
    nupC; nucleoside transporter

  4. NM_172980.4 → NP_766568.1  sodium/nucleoside cotransporter 2

    See identical proteins and their annotated locations for NP_766568.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AL844566
    Consensus CDS
    CCDS16663.1
    UniProtKB/Swiss-Prot
    O88627, Q8BJP1
    UniProtKB/TrEMBL
    Q7TMQ0
    Related
    ENSMUSP00000106154.2, ENSMUST00000110525.8
    Conserved Domains (1) summary
    TIGR00804
    Location:176 → 587
    nupC; nucleoside transporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    122256836..122291633
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162243.1 → XP_036018136.1  sodium/nucleoside cotransporter 2 isoform X1

    UniProtKB/Swiss-Prot
    O88627, Q8BJP1
    UniProtKB/TrEMBL
    Q7TMQ0
    Conserved Domains (1) summary
    TIGR00804
    Location:176 → 587
    nupC; nucleoside transporter

  2. XM_011239577.4 → XP_011237879.1  sodium/nucleoside cotransporter 2 isoform X3

    Conserved Domains (1) summary
    TIGR00804
    Location:176 → 509
    nupC; nucleoside transporter

  3. XM_036162242.1 → XP_036018135.1  sodium/nucleoside cotransporter 2 isoform X1

    UniProtKB/Swiss-Prot
    O88627, Q8BJP1
    UniProtKB/TrEMBL
    Q7TMQ0
    Related
    ENSMUSP00000106153.2, ENSMUST00000110524.2
    Conserved Domains (1) summary
    TIGR00804
    Location:176 → 587
    nupC; nucleoside transporter

  4. XM_036162244.1 → XP_036018137.1  sodium/nucleoside cotransporter 2 isoform X2

    UniProtKB/TrEMBL
    Q7TMQ0
    Conserved Domains (1) summary
    TIGR00804
    Location:96 → 507
    nupC; nucleoside transporter
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88627.2 GenPept UniProtKB/Swiss-Prot:O88627

Gene LinkOut

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