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Ppp2r2c protein phosphatase 2, regulatory subunit B, gamma [ Mus musculus (house mouse) ]

Gene ID: 269643, updated on 21-Oct-2021

Summary

Official Symbol
Ppp2r2cprovided by MGI
Official Full Name
protein phosphatase 2, regulatory subunit B, gammaprovided by MGI
Primary source
MGI:MGI:2442660
See related
Ensembl:ENSMUSG00000029120
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PR52; IMYPNO; IMYPNO1; 6330548O06Rik
Expression
Biased expression in cortex adult (RPKM 105.0), frontal lobe adult (RPKM 88.2) and 6 other tissues See more
Orthologs
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Genomic context

See Ppp2r2c in Genome Data Viewer
Location:
5; 5 B3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (37024187..37112422)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (36866846..36955078)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (37259809..37346317)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene Morf4 family associated protein 1 Neighboring gene mannosidase 2, alpha B2 Neighboring gene predicted gene, 52812 Neighboring gene protein phosphatase 2, regulatory subunit B, gamma, opposite strand Neighboring gene predicted gene, 52813 Neighboring gene wolframin ER transmembrane glycoprotein Neighboring gene janus kinase and microtubule interacting protein 1 Neighboring gene isocitrate dehydrogenase 3 (NAD+) beta pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein phosphatase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in peptidyl-serine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
NP_001346932.1
NP_766582.1
XP_006504034.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001360003.1NP_001346932.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC115722, AC169036
    Conserved Domains (2) summary
    COG5170
    Location:8424
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:1361
    7WD40; WD40 repeat [structural motif]
  2. NM_172994.3NP_766582.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform 1

    See identical proteins and their annotated locations for NP_766582.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC059811, CF537226
    Consensus CDS
    CCDS19244.1
    UniProtKB/Swiss-Prot
    Q8BG02
    Related
    ENSMUSP00000031003.8, ENSMUST00000031003.11
    Conserved Domains (3) summary
    COG5170
    Location:21438
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2775
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:15366
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    37024187..37112422
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006503971.4XP_006504034.1  serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform isoform X1

    Conserved Domains (2) summary
    COG5170
    Location:75490
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:79127
    7WD40; WD40 repeat [structural motif]
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