NOX1 NADPH oxidase 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NOX1provided by HGNC
Official Full Name: NADPH oxidase 1provided by HGNC
Primary source: HGNC:HGNC:7889
See related: Ensembl:ENSG00000007952 MIM:300225; AllianceGenome:HGNC:7889
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MOX1; NOH1; NOH-1; GP91-2; NOH-1L
Summary: This gene encodes a member of the NADPH oxidase family of enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Expression: Restricted expression toward colon (RPKM 30.7) See more
Orthologs: mouse all
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Genomic context

Location:: Xq22.1

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	X	NC_000023.11 (100843324..100874359, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	X	NC_060947.1 (99285862..99317015, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (100098313..100129348, complement)

Chromosome X - NC_000023.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway.
Title: PROX1 induction by autolysosomal activity stabilizes persister-like state of colon cancer via feedback repression of the NOX1-mTORC1 pathway.
Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis.
Title: Molecular interplay between NOX1 and autophagy in cadmium-induced prostate carcinogenesis.
Nrf2 regulates the expression of NOX1 in TNF-alpha-induced A549 cells.
Title: Nrf2 regulates the expression of NOX1 in TNF-α-induced A549 cells.
Serum NOX1 and Raftlin as new potential biomarkers of Major Depressive Disorder: A study in treatment-naive first episode patients.
Title: Serum NOX1 and Raftlin as new potential biomarkers of Major Depressive Disorder: A study in treatment-naive first episode patients.
Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation.
Title: Increased NOX1 and DUOX2 expression in the colonic mucosa of patients with chronic functional constipation.
Nuclear factor-kappaB regulates the transcription of NADPH oxidase 1 in human alveolar epithelial cells.
Title: Nuclear factor-kappaB regulates the transcription of NADPH oxidase 1 in human alveolar epithelial cells.
NOX1 inhibition attenuates the development of a pro-tumorigenic environment in experimental hepatocellular carcinoma.
Title: NOX1 inhibition attenuates the development of a pro-tumorigenic environment in experimental hepatocellular carcinoma.
ABCG1 Attenuates Oxidative Stress Induced by H2O2 through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells.
Title: ABCG1 Attenuates Oxidative Stress Induced by H(2)O(2) through the Inhibition of NADPH Oxidase and the Upregulation of Nrf2-Mediated Antioxidant Defense in Endothelial Cells.
NOX1/NADPH oxidase in bone marrow-derived cells modulates intestinal barrier function.
Title: NOX1/NADPH oxidase in bone marrow-derived cells modulates intestinal barrier function.
Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma.
Title: Serum level of Xanthine oxidase, Uric Acid, and NADPH oxidase1 in Stage I of Multiple Myeloma.

Submit: New GeneRIF Correction See all GeneRIFs (189)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 binding to CXCR4 induces NADPH oxidase-mediated production of superoxide radicals in neurons, which is involved in the activation of neutral sphingomyelinase	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 gp160 inhibits the cellular immune response and enhances oxidative stress mediated by NADPH oxidase	PubMed
Envelope transmembrane glycoprotein gp41	env	The 3S motif of HIV-1 gp41 stimulates ROS production by NADPH oxidase	PubMed
Nef	nef	NADPH oxidase is required for HIV-1 Nef-induced ROS production and endothelial apoptosis in human coronary arterial endothelial cells	PubMed
	nef	HIV-1 Nef-induced blockade of superoxide release is caused by the inhibition of NADPH oxidase activities in human macrophages; this inhibition is regulated by Nef-mediated increased synthesis and release of IL-10	PubMed
	nef	Nef induces the phosphorylation and then the translocation of the cytosolic subunit of NADPH oxidase complex p47(phox) to the plasma membrane	PubMed
	nef	Both Nef membrane localization and intact SH3-binding domain are involved in NADPH oxidase activation and superoxide anion release	PubMed
Tat	tat	PDGF-BB inhibits NADPH oxidase-mediated reactive oxygen species production induced by HIV-1 Tat and morphine treatment in neuroblastoma cells	PubMed
	tat	The NADPH oxidase inhibitors DPI and apocynin abrogate HIV-1 Tat-stimulated ERK1/2 activation in human microglia-like cells	PubMed
	tat	HIV-1 Tat increases CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase	PubMed
	tat	Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:482329

PMC228420P1 (e-PCR)
- UniSTS:272157

NoName (e-PCR)
- UniSTS:481387

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables NADP binding	IC Inferred by Curator more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables small GTPase binding	IPI Inferred from Physical Interaction more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables superoxide-generating NAD(P)H oxidase activity	IC Inferred by Curator more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables superoxide-generating NAD(P)H oxidase activity	TAS Traceable Author Statement more info	PubMed
enables superoxide-generating NADPH oxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in NADP metabolic process	IC Inferred by Curator more info	PubMed
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to hyperoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular stress response to acidic pH	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in extracellular matrix organization	IEA Inferred from Electronic Annotation more info
involved_in hydrogen peroxide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inflammatory response	TAS Traceable Author Statement more info	PubMed
involved_in intracellular pH elevation	IDA Inferred from Direct Assay more info	PubMed
involved_in intrinsic apoptotic signaling pathway in response to oxidative stress	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in oxygen metabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of integrin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of smooth muscle cell proliferation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of vascular endothelial growth factor production	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of blood pressure	TAS Traceable Author Statement more info	PubMed
involved_in regulation of systemic arterial blood pressure by renin-angiotensin	IEA Inferred from Electronic Annotation more info
involved_in respiratory burst	TAS Traceable Author Statement more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in superoxide anion generation	IBA Inferred from Biological aspect of Ancestor more info
involved_in superoxide anion generation	IDA Inferred from Direct Assay more info	PubMed
involved_in superoxide anion generation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NADPH oxidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NADPH oxidase complex	IDA Inferred from Direct Assay more info	PubMed
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
part_of monoatomic ion channel complex	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: NADPH oxidase 1

Names: NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase homolog-1; mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); mitogenic oxidase 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012567.1 RefSeqGene

Range

4987..36022

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001271815.2 → NP_001258744.1 NADPH oxidase 1 isoform 3

See identical proteins and their annotated locations for NP_001258744.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an in-frame 5' coding exon, compared to variant 1 (NOH-1L). The resulting isoform (3) has the same N- and C-termini but is shorter, compared to isoform 1.

Source sequence(s)

AF127763, AF166327, AI285296, AK292201, BX956931, DQ424904, Z83819

Consensus CDS

CCDS65298.1

UniProtKB/TrEMBL

A6NGA6, Q1ZYL4

Related

ENSP00000362051.4, ENST00000372960.8

Conserved Domains (2) summary

cd06186
Location:260 → 527

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:48 → 176

Ferric_reduct; Ferric reductase like transmembrane component
NM_007052.5 → NP_008983.2 NADPH oxidase 1 isoform 1

See identical proteins and their annotated locations for NP_008983.2

Status: REVIEWED

Description

Transcript Variant: This variant (1, alternately referred to as NOH-1L per PMID: 10615049) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AF127763, AF166327, BX956931, Z83819

Consensus CDS

CCDS14474.1

UniProtKB/Swiss-Prot

A8K836, O95691, Q2PP02, Q9Y5S8

UniProtKB/TrEMBL

Q1ZYL4

Related

ENSP00000362057.3, ENST00000372966.8

Conserved Domains (2) summary

cd06186
Location:297 → 564

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:66 → 213

Ferric_reduct; Ferric reductase like transmembrane component
NM_013955.3 → NP_039249.1 NADPH oxidase 1 isoform 2

See identical proteins and their annotated locations for NP_039249.1

Status: REVIEWED

Description

Transcript Variant: This variant (2, alternately referred to as NOH-1Lv per PMID: 10615049) lacks an alternate in-frame coding exon, compared to variant 1 (NOH-1L). The resulting isoform (2) has the same N- and C-termini but is shorter, compared to isoform 1.

Source sequence(s)

AF127763, AF166328, BX956931, Z83819

Consensus CDS

CCDS14475.1

UniProtKB/TrEMBL

Q8TCT3

Related

ENSP00000217885.5, ENST00000217885.5

Conserved Domains (2) summary

cd06186
Location:297 → 515

NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...

pfam01794
Location:66 → 213

Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000023.11 Reference GRCh38.p14 Primary Assembly

Range

100843324..100874359 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017029407.3 → XP_016884896.1 NADPH oxidase 1 isoform X1

UniProtKB/TrEMBL

Q1ZYL4

Alternate T2T-CHM13v2.0

Genomic

NC_060947.1 Alternate T2T-CHM13v2.0

Range

99285862..99317015 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054326825.1 → XP_054182800.1 NADPH oxidase 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_013954.1: Suppressed sequence

Description

NM_013954.1: This RefSeq was permanently suppressed because the submitters of the transcript data determined that this was not a biologically valid sequence.