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Catsperb cation channel sperm associated auxiliary subunit beta [ Mus musculus (house mouse) ]

Gene ID: 271036, updated on 5-Mar-2024

Summary

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Official Symbol
Catsperbprovided by MGI
Official Full Name
cation channel sperm associated auxiliary subunit betaprovided by MGI
Primary source
MGI:MGI:2443988
See related
Ensembl:ENSMUSG00000047014 AllianceGenome:MGI:2443988
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4931410B03; 4932415G16Rik
Summary
Predicted to act upstream of or within sperm capacitation. Located in cilium. Part of CatSper complex. Is expressed in germ cell of testis; seminiferous tubule; spermatid; spermatocyte; and testis. Orthologous to human CATSPERB (cation channel sperm associated auxiliary subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 8.2) See more
Orthologs
human all
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Genomic context

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See Catsperb in Genome Data Viewer
Location:
12 E; 12 51.23 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (101370904..101592268)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (101404645..101626009)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene cation channel, sperm-associated, beta pseudogene Neighboring gene myosin light chain, alkali, fast skeletal muscle, pseudogene Neighboring gene predicted gene, 22749 Neighboring gene STARR-seq mESC enhancer starr_33085 Neighboring gene STARR-seq mESC enhancer starr_33086 Neighboring gene predicted gene, 52022 Neighboring gene tandem C2 domains, nuclear Neighboring gene STARR-seq mESC enhancer starr_33088 Neighboring gene fibulin 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CatSperbeta, a novel transmembrane protein in the CatSper channel complex. Liu J, et al. J Biol Chem, 2007 Jun 29. PMID 17478420
  2. Structure of a mammalian sperm cation channel complex. Lin S, et al. Nature, 2021 Jul. PMID 34225353
  3. A novel gene required for male fertility and functional CATSPER channel formation in spermatozoa. Chung JJ, et al. Nat Commun, 2011 Jan 11. PMID 21224844, Free PMC Article
  4. Comparative analysis of testis protein evolution in rodents. Turner LM, et al. Genetics, 2008 Aug. PMID 18689890, Free PMC Article
  5. ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1. Wang W, et al. Biochem Biophys Res Commun, 2021 Oct 22. PMID 34474245, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sperm capacitation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within spermatogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of CatSper complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of CatSper complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex TAS
Traceable Author Statement
more info
 PubMed 
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in sperm principal piece IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cation channel sperm-associated auxiliary subunit beta
Names
CatSper channel subunit beta
catSper-beta
cation channel sperm-associated protein subunit beta
cation channel, sperm-associated, beta
catsper channel auxiliary subunit beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173023.2 → NP_766611.2  cation channel sperm-associated auxiliary subunit beta precursor

    See identical proteins and their annotated locations for NP_766611.2

    Status: VALIDATED

    Source sequence(s)
    AK029843, AK030010
    Consensus CDS
    CCDS26112.1
    UniProtKB/Swiss-Prot
    A2RTF1, Q8C0R2
    Related
    ENSMUSP00000052089.4, ENSMUST00000055156.5
    Conserved Domains (1) summary
    pfam15149
    Location:569 → 1087
    CATSPERB; Cation channel sperm-associated protein subunit beta protein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    101370904..101592268
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006515929.1 → XP_006515992.1  cation channel sperm-associated auxiliary subunit beta isoform X1

    Conserved Domains (1) summary
    pfam15149
    Location:569 → 754
    CATSPERB; Cation channel sperm-associated protein subunit beta protein family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2RTF1.1 GenPept UniProtKB/Swiss-Prot:A2RTF1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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