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ZNF777 zinc finger protein 777 [ Homo sapiens (human) ]

Gene ID: 27153, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF777provided by HGNC
Official Full Name
zinc finger protein 777provided by HGNC
Primary source
HGNC:HGNC:22213
See related
Ensembl:ENSG00000196453 MIM:619298; AllianceGenome:HGNC:22213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 4.5), brain (RPKM 4.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7q36.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149431363..149461062, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150613213..150642913, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (149128454..149158153, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375559 Neighboring gene uncharacterized LOC101928733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26814 Neighboring gene tRNA-Cys (anticodon GCA) 11-1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:149118879-149119378 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18755 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18756 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18757 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18758 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18759 Neighboring gene zinc finger protein 746 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr7:149191224-149192423 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:149193218-149194161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18760 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18761 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26815 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26816 Neighboring gene tRNA-Cys (anticodon GCA) 16-1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of zinc-finger protein 777 (ZNF777) inhibits proliferation at low cell density through down-regulation of FAM129A. Yuki R, et al. J Cell Biochem, 2015 Jun. PMID 25560148
  2. DUF3669, a "domain of unknown function" within ZNF746 and ZNF777, oligomerizes and contributes to transcriptional repression. Al Chiblak M, et al. BMC Mol Cell Biol, 2019 Dec 19. PMID 31856708, Free PMC Article
  3. Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 1999 Oct 29. PMID 10574462
  4. Mutations of the Transcriptional Corepressor ZMYM2 Cause Syndromic Urinary Tract Malformations. Connaughton DM, et al. Am J Hum Genet, 2020 Oct 1. PMID 32891193, Free PMC Article
  5. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. Giurato G, et al. Sci Data, 2018 Mar 6. PMID 29509190, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1285

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein heterooligomerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger protein 777

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015694.3 → NP_056509.2  zinc finger protein 777

    See identical proteins and their annotated locations for NP_056509.2

    Status: VALIDATED

    Source sequence(s)
    AB033111, AC073314, BC023985, BX444270, DR763452
    Consensus CDS
    CCDS43675.1
    UniProtKB/Swiss-Prot
    Q8N2R2, Q8N659, Q9ULD5
    Related
    ENSP00000247930.4, ENST00000247930.5
    Conserved Domains (7) summary
    smart00349
    Location:285 → 343
    KRAB; krueppel associated box
    COG5048
    Location:640 → 826
    COG5048; FOG: Zn-finger [General function prediction only]
    PRK10263
    Location:6 → 186
    PRK10263; DNA translocase FtsK; Provisional
    sd00017
    Location:696 → 716
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:669 → 686
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:546 → 568
    zf-C2H2; Zinc finger, C2H2 type
    pfam12417
    Location:199 → 255
    DUF3669; Zinc finger protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    149431363..149461062 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005249980.4 → XP_005250037.1  zinc finger protein 777 isoform X1

    Conserved Domains (8) summary
    cd07765
    Location:329 → 368
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:329 → 387
    KRAB; krueppel associated box
    COG5048
    Location:684 → 870
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:740 → 760
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:713 → 730
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:738 → 760
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:752 → 776
    zf-H2C2_2; Zinc-finger double domain
    pfam14353
    Location:681 → 730
    CpXC; CpXC protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    150613213..150642913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357906.1 → XP_054213881.1  zinc finger protein 777 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ULD5.3 GenPept UniProtKB/Swiss-Prot:Q9ULD5

Gene LinkOut

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