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TEM-1 hypothetical protein [ Escherichia coli ]

Gene ID: 2716540, discontinued on 1-Aug-2020
  • This record was discontinued.

Summary

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Gene symbol
TEM-1
Gene description
hypothetical protein
Locus tag
pC15-1a_020
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli
Lineage
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
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Genomic context

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Location:
plasmid: pC15-1a
Sequence:
NC_005327.1 (24050..24910)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_005327.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. analysis of the role of TEM-1 beta-lactamase in antibiotic resistance
    Title: Modelling proteins' hidden conformations to predict antibiotic resistance.
  2. The structural basis of sign epistasis between G238S and R164S, two adaptive mutations in TEM-1 beta-lactamase--an enzyme that endows antibiotics resistance.
    Title: Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.
  3. analyze the fitness effects of all single mutations in TEM-1 beta-lactamase (4,997 variants) under selection for the wild-type function (ampicillin resistance) and for a new function (cefotaxime resistance). Tolerance to mutation in this enzyme is bimodal and dependent on the strength of purifying selection in vivo.
    Title: Evolvability as a function of purifying selection in TEM-1 β-lactamase.
  4. 'cefpiromase' or 'cefepimase' phenotype of the clinical isolates non-susceptible to cefpirome and cefepime resulted from high expression of TEM-1 or OXA-1
    Title: False extended-spectrum {beta}-lactamase phenotype in clinical isolates of Escherichia coli associated with increased expression of OXA-1 or TEM-1 penicillinases and loss of porins.
  5. Increased folding stability of TEM-1 beta-lactamase by in vitro selection.
    Title: Increased folding stability of TEM-1 beta-lactamase by in vitro selection.
  6. The data suggest that L201P promotes tolerance of some deleterious TEM-1 mutations by enhancing the protein stability of these mutants.
    Title: Genetic and structural characterization of an L201P global suppressor substitution in TEM-1 beta-lactamase.
  7. Tyr-105 is important in substrate stabilization and discrimination in TEM-1 beta-lactamase.
    Title: Site-saturation mutagenesis of Tyr-105 reveals its importance in substrate stabilization and discrimination in TEM-1 beta-lactamase.
  8. pH-dependent quenching of the fluorescence of tryptophan residues of TEM-1 beta-lactamase from E. coli.
    Title: pH-dependent quenching of the fluorescence of tryptophan residues in class A beta-lactamase from E. coli (TEM-1).
  9. NMR assignments for TEM-1
    Title: 1H, 13C and 15N backbone resonance assignments for TEM-1, a 28.9 kDa beta-lactamase from E. coli.
Submit: New GeneRIF Correction

General protein information

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Preferred Names
hypothetical protein

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_005327.1 Reference assembly

    Range
    24050..24910
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_957565.1 hypothetical protein pC15-1a_020 [Escherichia coli]

    Status: PROVISIONAL

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
2018199A.1
P62593.1

Gene LinkOut

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Other Literature Sources
Molecular Biology Databases
Research Materials