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Rpl7a ribosomal protein L7A [ Mus musculus (house mouse) ]

Gene ID: 27176, updated on 5-Mar-2024

Summary

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Official Symbol
Rpl7aprovided by MGI
Official Full Name
ribosomal protein L7Aprovided by MGI
Primary source
MGI:MGI:1353472
See related
Ensembl:ENSMUSG00000062647 AllianceGenome:MGI:1353472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Surf3
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Predicted to be involved in maturation of LSU-rRNA. Located in membrane and polysomal ribosome. Is active in synapse. Is expressed in embryo. Orthologous to human RPL7A (ribosomal protein L7a). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14 (RPKM 336.0), CNS E11.5 (RPKM 322.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 A3; 2 19.1 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (26800697..26803330)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (26910685..26913312)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene surfeit gene 6 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:26758332-26758621 Neighboring gene mediator complex subunit 22 Neighboring gene predicted gene, 23969 Neighboring gene predicted gene, 22879 Neighboring gene predicted gene, 24134 Neighboring gene predicted gene, 57689 Neighboring gene surfeit gene 1 Neighboring gene surfeit gene 2 Neighboring gene surfeit gene 4 Neighboring gene STARR-positive B cell enhancer ABC_E2605 Neighboring gene serine/threonine kinase-like domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elucidation of the FKBP25-60S Ribosomal Protein L7a Stress Response Signaling During Ischemic Injury. Jiang Q, et al. Cell Physiol Biochem, 2018. PMID 29969783
  2. One of the tightly clustered genes of the mouse surfeit locus is a highly expressed member of a multigene family whose other members are predominantly processed pseudogenes. Huxley C, et al. Mol Cell Biol, 1988 Sep. PMID 3221868, Free PMC Article
  3. The MES-1 murine enhancer element is closely associated with the heterogeneous 5' ends of two divergent transcription units. Williams TJ, et al. Mol Cell Biol, 1986 Dec. PMID 3025660, Free PMC Article
  4. The mouse surfeit locus contains a very tight cluster of four "housekeeping" genes that is conserved through evolution. Williams T, et al. Proc Natl Acad Sci U S A, 1988 May. PMID 2453062, Free PMC Article
  5. Expression of ribosomal protein genes in mouse oocytes and early embryos. Taylor KD, et al. Mol Reprod Dev, 1992 Mar. PMID 1554502

See all (54) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC103146

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in maturation of LSU-rRNA IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in translation at postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in translation at presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cytosolic large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of cytosolic large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in cytosolic ribosome ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynapse NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in presynapse NAS
Non-traceable Author Statement
more info
 PubMed 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ribosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ribosome NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
 PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
large ribosomal subunit protein eL8
Names
60S ribosomal protein L7a
surfeit 3
surfeit locus protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013721.4 → NP_038749.1  large ribosomal subunit protein eL8

    See identical proteins and their annotated locations for NP_038749.1

    Status: VALIDATED

    Source sequence(s)
    AL773563
    Consensus CDS
    CCDS15815.1
    UniProtKB/Swiss-Prot
    P12970, Q91YM3
    UniProtKB/TrEMBL
    Q58ET1, Q5EBG5, Q6P1A9
    Related
    ENSMUSP00000099962.5, ENSMUST00000102898.5
    Conserved Domains (1) summary
    PTZ00365
    Location:16 → 266
    PTZ00365; 60S ribosomal protein L7Ae-like; Provisional

RNA

  1. NR_184739.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL773563
    Related
    ENSMUST00000143678.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    26800697..26803330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318923.2 → XP_017174412.1  large ribosomal subunit protein eL8 isoform X1

    Related
    ENSMUST00000137376.8
    Conserved Domains (1) summary
    PTZ00365
    Location:16 → 207
    PTZ00365; 60S ribosomal protein L7Ae-like; Provisional
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P12970.2 GenPept UniProtKB/Swiss-Prot:P12970

Gene LinkOut

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