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Agbl2 ATP/GTP binding protein-like 2 [ Mus musculus (house mouse) ]

Gene ID: 271813, updated on 25-May-2024

Summary

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Official Symbol
Agbl2provided by MGI
Official Full Name
ATP/GTP binding protein-like 2provided by MGI
Primary source
MGI:MGI:2443254
See related
Ensembl:ENSMUSG00000040812 AllianceGenome:MGI:2443254
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCP2; 4930524K04; A430081C19Rik
Summary
Enables metallocarboxypeptidase activity. Involved in protein side chain deglutamylation. Located in cytosol. Is expressed in brain. Orthologous to human AGBL2 (AGBL carboxypeptidase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 15.6), cerebellum adult (RPKM 1.1) and 1 other tissue See more
Orthologs
human all
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Genomic context

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See Agbl2 in Genome Data Viewer
Location:
2 E1; 2 50.37 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (90613029..90664781)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (90782685..90834437)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene nucleoporin 160 Neighboring gene predicted gene, 39872 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:90585318-90585501 Neighboring gene ribosomal protein L30, pseudogene 3 Neighboring gene formin binding protein 4 Neighboring gene STARR-seq mESC enhancer starr_05097 Neighboring gene predicted gene 13772 Neighboring gene STARR-seq mESC enhancer starr_05098 Neighboring gene STARR-positive B cell enhancer ABC_E11147 Neighboring gene STARR-positive B cell enhancer ABC_E9517 Neighboring gene mitochondrial carrier 2 Neighboring gene C1q and tumor necrosis factor related protein 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The carboxypeptidase-like substrate-binding site in Nna1 is essential for the rescue of the Purkinje cell degeneration (pcd) phenotype. Wang T, et al. Mol Cell Neurosci, 2006 Oct. PMID 16952463
  2. A novel subfamily of mouse cytosolic carboxypeptidases. Kalinina E, et al. FASEB J, 2007 Mar. PMID 17244818
  3. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Liu B, et al. Nat Commun, 2017 Aug 10. PMID 28794449, Free PMC Article
  4. The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids. Tort O, et al. Mol Biol Cell, 2014 Oct 1. PMID 25103237, Free PMC Article
  5. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Xia P, et al. Nat Immunol, 2016 Apr. PMID 26829768

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CCP2 and CCP3 are deglutamylases and are highly regulated proteins confined to ciliated tissues.
    Title: The cytosolic carboxypeptidases CCP2 and CCP3 catalyze posttranslational removal of acidic amino acids.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metallocarboxypeptidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metallocarboxypeptidase activity TAS
Traceable Author Statement
more info
  
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein side chain deglutamylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein side chain deglutamylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cytosolic carboxypeptidase 2
Names
carboxypeptidase 2, cytosolic
protein deglutamylase CCP2
NP_001343462.1
NP_848870.2
XP_006499692.1
XP_006499693.1
XP_006499694.1
XP_006499695.1
XP_006499696.1
XP_006499697.1
XP_006499702.1
XP_006499703.1
XP_006499705.1
XP_006499706.1
XP_006499707.1
XP_006499708.1
XP_006499709.1
XP_006499711.1
XP_011237881.1
XP_017174416.1
XP_030107540.1
XP_036018155.1
XP_036018156.1
XP_036018157.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356533.1 → NP_001343462.1  cytosolic carboxypeptidase 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence and in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a distinct N-terminus and a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL714026
    Consensus CDS
    CCDS89512.1
    UniProtKB/TrEMBL
    A0A0B4J1L6
    Related
    ENSMUSP00000047936.5, ENSMUST00000037206.11
    Conserved Domains (1) summary
    cd06907
    Location:370 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins

  2. NM_178755.4 → NP_848870.2  cytosolic carboxypeptidase 2 isoform 1

    See identical proteins and their annotated locations for NP_848870.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AK029744, AK029932
    Consensus CDS
    CCDS38177.2
    UniProtKB/Swiss-Prot
    A2AH35, Q09M08, Q09M09, Q09M10, Q09M11, Q09M12, Q8C529, Q8C9X4, Q8CDE6, Q8CDF6, Q8CDK2, Q8CDQ1
    UniProtKB/TrEMBL
    A0A0B4J1L6
    Related
    ENSMUSP00000048647.6, ENSMUST00000037219.12
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

RNA

  1. NR_151502.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' ends compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK029744, AL714026
    Related
    ENSMUST00000051831.13

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    90613029..90664781
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499630.3 → XP_006499693.1  cytosolic carboxypeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006499693.1

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  2. XM_006499632.2 → XP_006499695.1  cytosolic carboxypeptidase 2 isoform X2

    See identical proteins and their annotated locations for XP_006499695.1

    UniProtKB/Swiss-Prot
    A2AH35, Q09M08, Q09M09, Q09M10, Q09M11, Q09M12, Q8C529, Q8C9X4, Q8CDE6, Q8CDF6, Q8CDK2, Q8CDQ1
    UniProtKB/TrEMBL
    A0A0B4J1L6
    Related
    ENSMUSP00000129216.2, ENSMUST00000170320.8
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  3. XM_006499640.1 → XP_006499703.1  cytosolic carboxypeptidase 2 isoform X8

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  4. XM_006499643.1 → XP_006499706.1  cytosolic carboxypeptidase 2 isoform X9

    See identical proteins and their annotated locations for XP_006499706.1

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:361 → 611
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:213 → 340
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  5. XM_006499642.3 → XP_006499705.1  cytosolic carboxypeptidase 2 isoform X10

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  6. XM_036162264.1 → XP_036018157.1  cytosolic carboxypeptidase 2 isoform X8

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  7. XM_036162263.1 → XP_036018156.1  cytosolic carboxypeptidase 2 isoform X5

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  8. XM_030251680.2 → XP_030107540.1  cytosolic carboxypeptidase 2 isoform X5

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Related
    ENSMUST00000149037.8
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  9. XM_036162262.1 → XP_036018155.1  cytosolic carboxypeptidase 2 isoform X4

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:361 → 611
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:213 → 340
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  10. XM_011239579.3 → XP_011237881.1  cytosolic carboxypeptidase 2 isoform X9

    See identical proteins and their annotated locations for XP_011237881.1

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:361 → 611
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:213 → 340
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  11. XM_006499646.4 → XP_006499709.1  cytosolic carboxypeptidase 2 isoform X13

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:316 → 566
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:168 → 295
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  12. XM_006499631.4 → XP_006499694.1  cytosolic carboxypeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006499694.1

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  13. XM_006499629.4 → XP_006499692.1  cytosolic carboxypeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006499692.1

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  14. XM_017318927.3 → XP_017174416.1  cytosolic carboxypeptidase 2 isoform X6

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  15. XM_006499639.4 → XP_006499702.1  cytosolic carboxypeptidase 2 isoform X7

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  16. XM_006499644.4 → XP_006499707.1  cytosolic carboxypeptidase 2 isoform X11

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  17. XM_006499634.4 → XP_006499697.1  cytosolic carboxypeptidase 2 isoform X3

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:361 → 611
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:213 → 340
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  18. XM_006499645.4 → XP_006499708.1  cytosolic carboxypeptidase 2 isoform X12

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:316 → 566
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:168 → 295
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  19. XM_006499633.4 → XP_006499696.1  cytosolic carboxypeptidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006499696.1

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

  20. XM_006499648.5 → XP_006499711.1  cytosolic carboxypeptidase 2 isoform X14

    UniProtKB/TrEMBL
    A0A0B4J1L6
    Related
    ENSMUSP00000115632.2, ENSMUST00000136058.8
    Conserved Domains (2) summary
    cd06907
    Location:379 → 629
    M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins
    pfam18027
    Location:231 → 358
    Pepdidase_M14_N; Cytosolic carboxypeptidase N-terminal domain

RNA

  1. XR_866286.1 RNA Sequence

  2. XR_866284.3 RNA Sequence

  3. XR_001782954.3 RNA Sequence

  4. XR_004940620.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CDK2.1 GenPept UniProtKB/Swiss-Prot:Q8CDK2

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