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Pla2g4f phospholipase A2, group IVF [ Mus musculus (house mouse) ]

Gene ID: 271844, updated on 21-Apr-2024

Summary

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Official Symbol
Pla2g4fprovided by MGI
Official Full Name
phospholipase A2, group IVFprovided by MGI
Primary source
MGI:MGI:2685493
See related
Ensembl:ENSMUSG00000046971 AllianceGenome:MGI:2685493
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm647; Pla2zeta; 4732472I07Rik
Summary
Enables calcium-dependent phospholipase A2 activity and lysophospholipase activity. Acts upstream of or within several processes, including arachidonic acid secretion; cellular response to antibiotic; and prostaglandin biosynthetic process. Located in cytosol; ruffle membrane; and vesicle. Orthologous to human PLA2G4F (phospholipase A2 group IVF). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in stomach adult (RPKM 8.2), placenta adult (RPKM 7.1) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 E5; 2 60.31 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120130433..120144646, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120299952..120314165, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene phospholipase A2, group IVE Neighboring gene predicted gene, 52575 Neighboring gene STARR-seq mESC enhancer starr_05506 Neighboring gene predicted gene, 52560 Neighboring gene phospholipase A2, group IVD Neighboring gene VPS39 HOPS complex subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120178706-120178815 Neighboring gene transmembrane protein 87A Neighboring gene STARR-positive B cell enhancer ABC_E10133 Neighboring gene glucosidase, alpha; neutral C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. Yun B, et al. J Biol Chem, 2014 Jan 17. PMID 24297180, Free PMC Article
  2. Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. Ghosh M, et al. J Biol Chem, 2007 Apr 20. PMID 17293613, Free PMC Article
  3. Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}. Ohto T, et al. J Biol Chem, 2005 Jul 1. PMID 15866882
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. murine cytosolic phospholipases A2 delta, epsilon, and zeta form a gene cluster with cPLA(2)beta
    Title: Identification of novel cytosolic phospholipase A(2)s, murine cPLA(2){delta}, {epsilon}, and {zeta}, which form a gene cluster with cPLA(2){beta}.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables lysophospholipase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within arachidonic acid secretion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to antibiotic IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within fatty acid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycerophospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within prostaglandin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in ruffle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ruffle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cytosolic phospholipase A2 zeta
Names
cPLA2-zeta
NP_001019316.1
NP_001350002.1
NP_001350003.1
NP_001350004.1
XP_006499715.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024145.3 → NP_001019316.1  cytosolic phospholipase A2 zeta isoform 1

    See identical proteins and their annotated locations for NP_001019316.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL844608
    Consensus CDS
    CCDS16618.1
    UniProtKB/Swiss-Prot
    A2AQJ2, Q50L41, Q80VQ8, Q80VV9
    UniProtKB/TrEMBL
    B7ZNT9
    Related
    ENSMUSP00000062607.8, ENSMUST00000054651.8
    Conserved Domains (3) summary
    cd04036
    Location:46 → 162
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    smart00022
    Location:307 → 796
    PLAc; Cytoplasmic phospholipase A2, catalytic subunit
    cl11396
    Location:300 → 848
    Patatin_and_cPLA2; Patatins and Phospholipases

  2. NM_001363073.1 → NP_001350002.1  cytosolic phospholipase A2 zeta isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AL844608
    UniProtKB/TrEMBL
    B2RWZ7
    Conserved Domains (2) summary
    cd04036
    Location:46 → 162
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    cl11396
    Location:300 → 847
    Patatin_and_cPLA2; Patatins and Phospholipases

  3. NM_001363074.1 → NP_001350003.1  cytosolic phospholipase A2 zeta isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AL844608
    UniProtKB/TrEMBL
    B7ZNT9
    Conserved Domains (2) summary
    cd04036
    Location:45 → 161
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    cl11396
    Location:299 → 847
    Patatin_and_cPLA2; Patatins and Phospholipases

  4. NM_001363075.1 → NP_001350004.1  cytosolic phospholipase A2 zeta isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (4) has the same N- and C-termini but is 2 aa shorter compared to isoform 1.
    Source sequence(s)
    AL844608
    UniProtKB/TrEMBL
    B7ZNT9
    Conserved Domains (2) summary
    cd04036
    Location:45 → 161
    C2_cPLA2; C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
    cl11396
    Location:299 → 846
    Patatin_and_cPLA2; Patatins and Phospholipases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    120130433..120144646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499652.3 → XP_006499715.1  cytosolic phospholipase A2 zeta isoform X1

    Related
    ENSMUST00000142183.2
    Conserved Domains (2) summary
    pfam18695
    Location:2 → 103
    cPLA2_C2; Cytosolic phospholipases A2 C2-domain
    cl11396
    Location:102 → 650
    Patatin_and_cPLA2; Patatins and Phospholipases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q50L41.3 GenPept UniProtKB/Swiss-Prot:Q50L41

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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