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Tbcel tubulin folding cofactor E-like [ Mus musculus (house mouse) ]

Gene ID: 272589, updated on 11-Apr-2024

Summary

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Official Symbol
Tbcelprovided by MGI
Official Full Name
tubulin folding cofactor E-likeprovided by MGI
Primary source
MGI:MGI:1925543
See related
Ensembl:ENSMUSG00000037287 AllianceGenome:MGI:1925543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lrrc35; D330014K23; E130107N23Rik
Summary
Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. Orthologous to human TBCEL (tubulin folding cofactor E like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 10.3), liver E14 (RPKM 10.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Tbcel in Genome Data Viewer
Location:
9 A5.1; 9 23.71 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (42323612..42383534, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (42412316..42472238, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26272 Neighboring gene tectorin alpha Neighboring gene STARR-seq mESC enhancer starr_23902 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:42236216-42236386 Neighboring gene predicted gene, 47629 Neighboring gene STARR-seq mESC enhancer starr_23903 Neighboring gene STARR-seq mESC enhancer starr_23904 Neighboring gene STARR-positive B cell enhancer ABC_E9327 Neighboring gene predicted gene 16322 Neighboring gene glutamate receptor, ionotropic, kainate 4 Neighboring gene predicted gene, 36590 Neighboring gene STARR-seq mESC enhancer starr_23909 Neighboring gene STARR-seq mESC enhancer starr_23910 Neighboring gene STARR-seq mESC enhancer starr_23911 Neighboring gene predicted gene, 36648

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
  2. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  5. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables alpha-tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-chaperonin tubulin folding pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in tubulin complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tubulin-specific chaperone cofactor E-like protein
Names
leucine-rich repeat-containing protein 35

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357656.3 → NP_001344585.2  tubulin-specific chaperone cofactor E-like protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC136903, AC156631
    Consensus CDS
    CCDS90542.1
    UniProtKB/Swiss-Prot
    B9EID8, Q8C5W3, Q8C7A5
    Related
    ENSMUSP00000065125.8, ENSMUST00000066179.14
    Conserved Domains (5) summary
    sd00031
    Location:78 → 101
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:129 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    cd17045
    Location:337 → 422
    Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
    pfam14580
    Location:191 → 304
    LRR_9; Leucine-rich repeat
    cd21340
    Location:50 → 113
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  2. NM_001357657.3 → NP_001344586.1  tubulin-specific chaperone cofactor E-like protein isoform b

    Status: VALIDATED

    Source sequence(s)
    AC136903, AC156631
    Consensus CDS
    CCDS23088.1
    UniProtKB/Swiss-Prot
    B9EID8, Q8C5W3, Q8C7A5
    Related
    ENSMUSP00000114721.2, ENSMUST00000125995.8
    Conserved Domains (5) summary
    sd00031
    Location:78 → 101
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:129 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    cd17045
    Location:337 → 422
    Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
    pfam14580
    Location:191 → 304
    LRR_9; Leucine-rich repeat
    cd21340
    Location:50 → 113
    PPP1R42; protein phosphatase 1 regulatory subunit 42

  3. NM_001378604.1 → NP_001365533.1  tubulin-specific chaperone cofactor E-like protein isoform c

    Status: VALIDATED

    Source sequence(s)
    AC136903, AC156631
    Conserved Domains (3) summary
    sd00033
    Location:51 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    cd17045
    Location:212 → 297
    Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
    pfam14580
    Location:66 → 179
    LRR_9; Leucine-rich repeat

  4. NM_173038.5 → NP_766626.1  tubulin-specific chaperone cofactor E-like protein isoform b

    See identical proteins and their annotated locations for NP_766626.1

    Status: VALIDATED

    Source sequence(s)
    AC136903, AC156631
    Consensus CDS
    CCDS23088.1
    UniProtKB/Swiss-Prot
    B9EID8, Q8C5W3, Q8C7A5
    Related
    ENSMUSP00000067882.6, ENSMUST00000066148.12
    Conserved Domains (5) summary
    sd00031
    Location:78 → 101
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:129 → 148
    LRR_RI; leucine-rich repeat [structural motif]
    cd17045
    Location:337 → 422
    Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
    pfam14580
    Location:191 → 304
    LRR_9; Leucine-rich repeat
    cd21340
    Location:50 → 113
    PPP1R42; protein phosphatase 1 regulatory subunit 42

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    42323612..42383534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006510396.5 → XP_006510459.1  tubulin-specific chaperone cofactor E-like protein isoform X1

    See identical proteins and their annotated locations for XP_006510459.1

    Conserved Domains (3) summary
    sd00033
    Location:51 → 76
    LRR_RI; leucine-rich repeat [structural motif]
    cd17045
    Location:212 → 297
    Ubl_TBCEL; ubiquitin-like (Ubl) domain found in tubulin-specific chaperone cofactor E-like protein (TBCEL) and similar proteins
    pfam14580
    Location:66 → 179
    LRR_9; Leucine-rich repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C5W3.1 GenPept UniProtKB/Swiss-Prot:Q8C5W3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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